PubMed Central
pmc.ncbi.nlm.nih.gov › articles › PMC3614697
Free Radicals, Antioxidants in Disease and Health - PMC
Free radicals and oxidants play a dual role as both toxic and beneficial compounds, since they can be either harmful or helpful to the body. They are produced either from normal cell metabolisms in situ or from external sources (pollution, cigarette ...
ELI5: What are free radicals and antioxidants?
All day, you breathe air in and out. This is to get yourself oxygen, a type of atom which is very important to have. Your body needs oxygen because of one thing oxygen has, that not many other atoms have. Oxygen is very sticky. It's one of the stickiest atoms there are. Oxygen likes to stick to stuff because of it's "electronegativity", and it will try to stick to whatever it can. When you breathe in oxygen from the air, it comes in pairs. These are two oxygen atoms stuck together, making their stickyness cancel out. Your body knows how to unstick them and use them to glue other atoms together to form molecules that can be used throughout the body to make things, from bones to skin. But when a single lonely oxygen atom gets free, we call it a "free radical" A free radical is just a single oxygen atom, but remember how we said oxygen is very sticky? It will try to stick itself onto other molecules, even when it shouldn't! This can easily break things, because the molecules in your body have to be very carefully made. If an oxygen molecule just walks up and sticks to it, this is very bad. Lucky for us, there's other types of molecules called "antioxidants". Antioxidants are molecules too, but they have a special slot just for sticky oxygen atoms. Antioxidant molecules are sticky too, but they have a shape that only fits with a sticky oxygen atom. If you eat antioxidants, they will go around your body gobbling up all the sticky oxygen atoms, before they stick to something they shouldn't. They only work on sticky oxygen, they don't work on the paired oxygen you breath in, so don't worry about them using all the oxygen in your body. Some foods just happen to have a lot of antioxidants. It's because food is made up of molecules too, and some of those have more antioxidants than others. They make them on their own as they grow so they don't get broken by sticky lone oxygen molecules either. Your body makes it's own antioxidants too! But sometimes it can't make enough on it's own, so you need to eat them to get more. The healthier you eat, the more antioxidants you can get, and the less likely your body will get hurt by those sticky lone oxygen molecules. More on reddit.com
ELI5 What are free radicals?
Chemically speaking, a radical is an atom which has a "free" electron, one that is not bound and not an electron pair. A good example is the oxygen radical O2(-), the hyperoxid anion. These molecules have a strong urge to react with stuff - in the lab and in your body. Your body usually deals with them very well, you have enzymes which are super fast in converting radicals into less toxic species. But these enzymes have limits. If you have too much free radicals, they will form DNA-adducts, damage your cells or lead to inflammation (this is called oxidative stress). Marketing techniques nowadays often tell you that this or that acts as a radical annihilator and it is healthy for you. That may be true on a molecular level, but the effect is so tiny that often you don't see it. Your body is usually capable of dealing with "normal" stress. Fun fact: A famous story about Pauling was that he ate a spoonful of ascorbic acid (which binds radicals) every day to protect against cancer and flu. He died with 93 years. More on reddit.com
ELI5: Are free radicals harmful?
Essentially, free radicals are highly reactive and have a tendency to damage biological things. But sometimes you NEED to damage biological things, and in those cases it's good to have some around. Ultimately, you've evolved to have a certain level of free radicals, and any deviation from that level will make your body behave in a manner it isn't optimised for. That means that too many or too few are both potentially dangerous for different reasons. More on reddit.com
'Free radicals': Science or bullshit?
Free radicals inside your body are a source of damage/oxidative stress.
Putting baking soda in your bath water won't do anything for that, though.
More on reddit.comHow are free radicals and antioxidants connected?
Antioxidants are the body's way of fighting back against oxidative stress. They are often called 'free radical scavengers' because they can prevent and repair damage caused by free radicals. Antioxidants can be produced by the body and are also found in many foods, such as fruits, vegetables, nuts, and whole grains.
mdanderson.org
mdanderson.org › cancerwise blog › 2024 › 08 › what are free radicals? a dietitian explains
What are free radicals? A dietitian explains | UT MD Anderson
How do free radicals affect the body?
High levels of free radicals can cause oxidative stress, which damages cells, proteins, and DNA. This damage can disrupt cellular functions and contribute to a variety of health issues, including arthritis, diabetes, heart disease, Alzheimer's disease, and cancer, as well as premature aging.
mdanderson.org
mdanderson.org › cancerwise blog › 2024 › 08 › what are free radicals? a dietitian explains
What are free radicals? A dietitian explains | UT MD Anderson
How else can we reduce free radical exposure?
In addition to eating a diet rich in antioxidants, you can reduce free radical exposure by avoiding smoking, air pollutants, pesticides, and industrial chemicals. To help combat oxidative stress, it is also recommended to get regular physical activity and plenty of rest.
mdanderson.org
mdanderson.org › cancerwise blog › 2024 › 08 › what are free radicals? a dietitian explains
What are free radicals? A dietitian explains | UT MD Anderson
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Nature
nature.com › cell death discovery › review articles › article
Free radicals and their impact on health and antioxidant defenses: a review | Cell Death Discovery
January 24, 2025 - Free radicals, characterized by the presence of unpaired electrons, are highly reactive species that play a significant role in human health. These molecules can be generated through various endogenous processes, such as mitochondrial respiration and immune cell activation, as well as exogenous sources, including radiation, pollution, and smoking.
PubMed Central
pmc.ncbi.nlm.nih.gov › articles › PMC3249911
Free radicals, antioxidants and functional foods - PMC - NIH
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PubMed Central
pmc.ncbi.nlm.nih.gov › articles › PMC4310837
Free Radicals: Properties, Sources, Targets, and Their Implication in Various Diseases - PMC
The free radicals, both the reactive oxygen species (ROS) and reactive nitrogen species (RNS), are derived from both endogenous sources (mitochondria, peroxisomes, endoplasmic reticulum, phagocytic cells etc.) and exogenous sources (pollution, alcohol, tobacco smoke, heavy metals, transition metals, industrial solvents, pesticides, certain drugs like halothane, paracetamol, and radiation).
Wikipedia
en.wikipedia.org › wiki › Radical_(chemistry)
Radical (chemistry) - Wikipedia
5 days ago - For most organic radicals in solution, the dominant reaction is simply their dimerization, also called recombination: ... Because of the strength of the C-C bond, these reactions are irreversible. In free-radical additions, a radical adds to an alkene. This addition generates a new radical, ...
ScienceDirect
sciencedirect.com › topics › neuroscience › free-radical
Free Radical - an overview | ScienceDirect Topics
A free radical is a molecule that contains at least one unpaired valence electron. Chemical species are more stable when their electrons are paired with other electrons, so free radicals are often unstable and chemically reactive. In particular, when a free radical encounters another molecule ...
Reddit
reddit.com › r/explainlikeimfive › eli5: what are free radicals and antioxidants?
r/explainlikeimfive on Reddit: ELI5: What are free radicals and antioxidants?
May 29, 2013 -
What do they do that makes them bad/good? Why do some foods have more of the antioxidants?
Top answer 1 of 15
417
All day, you breathe air in and out. This is to get yourself oxygen, a type of atom which is very important to have. Your body needs oxygen because of one thing oxygen has, that not many other atoms have. Oxygen is very sticky. It's one of the stickiest atoms there are. Oxygen likes to stick to stuff because of it's "electronegativity", and it will try to stick to whatever it can. When you breathe in oxygen from the air, it comes in pairs. These are two oxygen atoms stuck together, making their stickyness cancel out. Your body knows how to unstick them and use them to glue other atoms together to form molecules that can be used throughout the body to make things, from bones to skin. But when a single lonely oxygen atom gets free, we call it a "free radical" A free radical is just a single oxygen atom, but remember how we said oxygen is very sticky? It will try to stick itself onto other molecules, even when it shouldn't! This can easily break things, because the molecules in your body have to be very carefully made. If an oxygen molecule just walks up and sticks to it, this is very bad. Lucky for us, there's other types of molecules called "antioxidants". Antioxidants are molecules too, but they have a special slot just for sticky oxygen atoms. Antioxidant molecules are sticky too, but they have a shape that only fits with a sticky oxygen atom. If you eat antioxidants, they will go around your body gobbling up all the sticky oxygen atoms, before they stick to something they shouldn't. They only work on sticky oxygen, they don't work on the paired oxygen you breath in, so don't worry about them using all the oxygen in your body. Some foods just happen to have a lot of antioxidants. It's because food is made up of molecules too, and some of those have more antioxidants than others. They make them on their own as they grow so they don't get broken by sticky lone oxygen molecules either. Your body makes it's own antioxidants too! But sometimes it can't make enough on it's own, so you need to eat them to get more. The healthier you eat, the more antioxidants you can get, and the less likely your body will get hurt by those sticky lone oxygen molecules.
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Let's start by talking about oxygen. As I'm sure you're aware, oxygen is essential for us to carry out all sorts of biological processes. Unfortunately though, oxygen is extremely reactive and forms a bunch of different things - one of which is commonly referred to as a "free radical." What this means is that the oxygen atom has one unpaired electron. Electrons love to be in pairs, and this oxygen atom will do whatever it takes to get another one. This is often at the expense of other essential components of cells (proteins, DNA, carbohydrates). A free radical doesn't have to involve oxygen; it refers to any element with that unpaired valence electron. The oxygen free radicals are commonly referred to as "reactive oxygen species (ROS)." Antioxidants are compounds that essentially neutralize the ROS. They are able to give up one extra electron to the oxygen safely without allowing the ROS to cause any damage elsewhere. Vitamins A, C, and E are the antioxidant vitamins. Different foods have a different make-up, so they have different antioxidant properties.
Cigna Healthcare
cigna.com › home › knowledge center › wellness library › free radicals
Free radicals | Cigna
A free radical is an atom or molecule with at least one unpaired electron, making it especially reactive to other atoms or groups of atoms. If free radicals react with certain chemicals in the body, they may interfere with the ability of cells to function normally.
Colorado State University
vivo.colostate.edu › hbooks › pathphys › topics › radicals.html
Free Radicals and Reactive Oxygen
A radical (often, but unnecessarily called a free radical) is an atom or group of atoms that have one or more unpaired electrons. Radicals can have positive, negative or neutral charge.
NCI
cancer.gov › about-cancer › causes-prevention › risk › diet › antioxidants-fact-sheet
Antioxidants and Cancer Prevention - NCI
Free radicals are highly reactive chemicals that have the potential to harm cells. They are created when an atom or a molecule (a chemical that has two or more atoms) either gains or loses an electron (a small negatively charged particle found in atoms). Free radicals are formed naturally in ...
Maurerfoundation
maurerfoundation.org › what-are-free-radicals
What Are Free Radicals? | Maurer Foundation
July 11, 2012 - Free radicals are highly reactive and unstable molecules, usually oxygen molecules, but not always. Their unstable nature is caused by having an unpaired electron. As a result of this unpaired electron, free radicals seek out and take electrons from other molecules, which oftentimes causes ...
Harvard Health
health.harvard.edu › healthy-aging-and-longevity › understanding-antioxidants
Understanding antioxidants - Harvard Health
January 10, 2019 - Some vitamins and minerals — including vitamins C and E and the minerals copper, zinc, and selenium — serve as antioxidants, in addition to other vital roles. "Antioxidant" is a general term for any compound that can counteract unstable molecules called free radicals that damage DNA, cell membranes, and ...
Advmedny
advmedny.com › post › what-are-free-radicals-and-how-do-they-affect-the-body
What Are Free Radicals and How Do They Affect the Body? | Cardiology & Neurology Specialists located in Queens, Forest Hills and Brighton Beach, Brooklyn, NY | Advanced Medical Care
December 9, 2024 - Although fried foods are free radical instigators, you need plenty of healthy fats, like those found in avocados, olive oil, and fatty fish, to keep your heart and brain healthy and counteract the effects of free radicals. On the other hand, processed foods and added sugars contribute to inflammation and oxidative stress. Regular exercise reduces oxidative stress by boosting your body’s natural antioxidant defenses. Limit your alcohol consumption and don’t smoke — both habits can increase free radical production.