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MD Anderson Cancer Center
mdanderson.org › cancerwise blog › 2024 › 08 › what are free radicals? a dietitian explains
What are free radicals? A dietitian explains | UT MD Anderson
The National Cancer Institute (NCI) writes that free radicals are created when an atom or molecule gains or loses an electron.
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PubMed Central
pmc.ncbi.nlm.nih.gov › articles › PMC3614697
Free Radicals, Antioxidants in Disease and Health - PMC
The human body has several mechanisms to counteract oxidative stress by producing antioxidants, which are either naturally produced in situ, or externally supplied through foods and/or supplements. Endogenous and exogenous antioxidants act as “free radical scavengers” by preventing and repairing damages caused by ROS and RNS, and therefore can enhance the immune defense and lower the risk of cancer and degenerative diseases (11-15).
Discussions

ELI5: What are free radicals and antioxidants?
All day, you breathe air in and out. This is to get yourself oxygen, a type of atom which is very important to have. Your body needs oxygen because of one thing oxygen has, that not many other atoms have. Oxygen is very sticky. It's one of the stickiest atoms there are. Oxygen likes to stick to stuff because of it's "electronegativity", and it will try to stick to whatever it can. When you breathe in oxygen from the air, it comes in pairs. These are two oxygen atoms stuck together, making their stickyness cancel out. Your body knows how to unstick them and use them to glue other atoms together to form molecules that can be used throughout the body to make things, from bones to skin. But when a single lonely oxygen atom gets free, we call it a "free radical" A free radical is just a single oxygen atom, but remember how we said oxygen is very sticky? It will try to stick itself onto other molecules, even when it shouldn't! This can easily break things, because the molecules in your body have to be very carefully made. If an oxygen molecule just walks up and sticks to it, this is very bad. Lucky for us, there's other types of molecules called "antioxidants". Antioxidants are molecules too, but they have a special slot just for sticky oxygen atoms. Antioxidant molecules are sticky too, but they have a shape that only fits with a sticky oxygen atom. If you eat antioxidants, they will go around your body gobbling up all the sticky oxygen atoms, before they stick to something they shouldn't. They only work on sticky oxygen, they don't work on the paired oxygen you breath in, so don't worry about them using all the oxygen in your body. Some foods just happen to have a lot of antioxidants. It's because food is made up of molecules too, and some of those have more antioxidants than others. They make them on their own as they grow so they don't get broken by sticky lone oxygen molecules either. Your body makes it's own antioxidants too! But sometimes it can't make enough on it's own, so you need to eat them to get more. The healthier you eat, the more antioxidants you can get, and the less likely your body will get hurt by those sticky lone oxygen molecules. More on reddit.com
🌐 r/explainlikeimfive
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May 29, 2013
ELI5 What are free radicals?
Chemically speaking, a radical is an atom which has a "free" electron, one that is not bound and not an electron pair. A good example is the oxygen radical O2(-), the hyperoxid anion. These molecules have a strong urge to react with stuff - in the lab and in your body. Your body usually deals with them very well, you have enzymes which are super fast in converting radicals into less toxic species. But these enzymes have limits. If you have too much free radicals, they will form DNA-adducts, damage your cells or lead to inflammation (this is called oxidative stress). Marketing techniques nowadays often tell you that this or that acts as a radical annihilator and it is healthy for you. That may be true on a molecular level, but the effect is so tiny that often you don't see it. Your body is usually capable of dealing with "normal" stress. Fun fact: A famous story about Pauling was that he ate a spoonful of ascorbic acid (which binds radicals) every day to protect against cancer and flu. He died with 93 years. More on reddit.com
🌐 r/explainlikeimfive
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May 14, 2018
ELI5: Are free radicals harmful?
Essentially, free radicals are highly reactive and have a tendency to damage biological things. But sometimes you NEED to damage biological things, and in those cases it's good to have some around. Ultimately, you've evolved to have a certain level of free radicals, and any deviation from that level will make your body behave in a manner it isn't optimised for. That means that too many or too few are both potentially dangerous for different reasons. More on reddit.com
🌐 r/explainlikeimfive
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March 31, 2024
'Free radicals': Science or bullshit?

Free radicals inside your body are a source of damage/oxidative stress.

Putting baking soda in your bath water won't do anything for that, though.

More on reddit.com
🌐 r/askscience
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July 25, 2012
People also ask

How are free radicals and antioxidants connected?
Antioxidants are the body's way of fighting back against oxidative stress. They are often called 'free radical scavengers' because they can prevent and repair damage caused by free radicals. Antioxidants can be produced by the body and are also found in many foods, such as fruits, vegetables, nuts, and whole grains.
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mdanderson.org
mdanderson.org › cancerwise blog › 2024 › 08 › what are free radicals? a dietitian explains
What are free radicals? A dietitian explains | UT MD Anderson
How do free radicals affect the body?
High levels of free radicals can cause oxidative stress, which damages cells, proteins, and DNA. This damage can disrupt cellular functions and contribute to a variety of health issues, including arthritis, diabetes, heart disease, Alzheimer's disease, and cancer, as well as premature aging.
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mdanderson.org
mdanderson.org › cancerwise blog › 2024 › 08 › what are free radicals? a dietitian explains
What are free radicals? A dietitian explains | UT MD Anderson
How else can we reduce free radical exposure?
In addition to eating a diet rich in antioxidants, you can reduce free radical exposure by avoiding smoking, air pollutants, pesticides, and industrial chemicals. To help combat oxidative stress, it is also recommended to get regular physical activity and plenty of rest.
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mdanderson.org
mdanderson.org › cancerwise blog › 2024 › 08 › what are free radicals? a dietitian explains
What are free radicals? A dietitian explains | UT MD Anderson
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Maurerfoundation
maurerfoundation.org › what-are-free-radicals
What Are Free Radicals? | Maurer Foundation
Free radicals are highly reactive and unstable molecules, usually oxygen molecules, but not always. Their unstable nature is caused by having an unpaired electron. As a result of this unpaired electron, free radicals seek out and take electrons from other molecules, which oftentimes causes ...
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PubMed Central
pmc.ncbi.nlm.nih.gov › articles › PMC3249911
Free radicals, antioxidants and functional foods: Impact on human health - PMC
A free radical can be defined as any molecular species capable of independent existence that contains an unpaired electron in an atomic orbital. The presence of an unpaired electron results in certain common properties that are shared by most radicals. Many radicals are unstable and highly reactive.
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Helendaledermatology
helendaledermatology.com › home › blog › what the heck are free radicals and why should we care?
What the Heck are Free Radicals and Why Should We Care? | Helendale Dermatology
January 22, 2021 - This unbalanced molecule is often called a "free radical." Free radicals themselves don't directly come from UV radiation, sun exposure, cigarette smoke, poor diet, pollution, or stress, but are created by the body in response to these outside forces.
Call   5852665420
Address   500 Helendale Rd, 14609, Rochester
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National Cancer Institute (.gov)
cancer.gov › publications › dictionaries › cancer-terms › def › free-radical
Definition of free radical - NCI Dictionary of Cancer Terms
NCI's Dictionary of Cancer Terms provides easy-to-understand definitions for words and phrases related to cancer and medicine.
Find elsewhere
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Dr. Axe
draxe.com › health › free radicals: effects on health and how to combat them
Free Radicals: Effects on Health and How to Combat Them - Dr. Axe
April 9, 2024 - The definition of free radicals is “uncharged molecules (typically highly reactive and short-lived) having an unpaired valence electron.” According to the Pharmacognosy Review, “reactive oxygen species and reactive nitrogen species are ...
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Ctorthostvincents
ctorthostvincents.org › health-resources › health-library › detail
Free radicals | CT Orthopaedic Institute | St. Vincent's ...
Has info on finger, hand, and wrist problems as well as shoulder injuries. Also has info on osteoarthritis and fibromyalgia with links to low back pain exercises and info on tennis elbow surgery.
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Mybrainco
mybrainco.com › blogs › library › what-are-free-radicals
What are Free Radicals?
April 5, 2023 - myBrainCo. offers evidence-backed nutritional health supplements, scientifically formulated to support optimal body and brain performance.
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1st Phorm
1stphorm.com › health & fitness blog › what are free radicals?
What are Free Radicals? – 1st Phorm
June 4, 2024 - The products and situations below promote free radical production: ... An abundance of free radicals causes premature aging (known as the free radical theory of aging) such as loss of elasticity of the skin and grey hair.
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Wikipedia
en.wikipedia.org › wiki › Free-radical_theory_of_aging
Free-radical theory of aging - Wikipedia
December 14, 2025 - The free radical theory of aging states that organisms age because cells accumulate free radical damage over time. A free radical is any atom or molecule that has a single unpaired electron in an outer shell. While a few free radicals such as melanin are not chemically reactive, most biologically ...
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Health
health.com › what-is-a-free-radical-8771647
Where Do Free Radicals Come From, and Why Does It Matter for Your Health?
June 7, 2025 - Free radicals are highly unstable, reactive molecules in your body that can damage your cells and DNA, contributing to inflammation and several diseases.
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Harvard Health
health.harvard.edu › healthy-aging-and-longevity › understanding-antioxidants
Understanding antioxidants - Harvard Health
January 31, 2019 - Some vitamins and minerals — including vitamins C and E and the minerals copper, zinc, and selenium — serve as antioxidants, in addition to other vital roles. "Antioxidant" is a general term for any compound that can counteract unstable molecules called free radicals that damage DNA, cell membranes, and ...
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Mayo Clinic Proceedings
mayoclinicproceedings.org › article › S0025-6196(12)64861-7 › fulltext
Free Radicals in Medicine. I. Chemical Nature and Biologic Reactions* - Mayo Clinic Proceedings
April 1, 1988 - Free radicals are reactive chemical species that differ from other compounds in that they have unpaired electrons in their outer orbitals. They are capable of damaging cellular components, and accumulating evidence suggests they may contribute ...
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Medicine LibreTexts
med.libretexts.org › bookshelves › nutrition › an introduction to nutrition (zimmerman) › 8: nutrients important as antioxidants
8.2: Generation of Free Radicals in the Body - Medicine LibreTexts
August 10, 2020 - Atoms and molecules such as superoxide that have unpaired electrons are called free radicals; those containing oxygen are more specifically referred to as reactive oxygen species.
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Medical News Today
medicalnewstoday.com › articles › 318652
Free radicals: How do they affect the body?
February 28, 2025 - Free radicals are unstable molecules that can damage cells and their DNA. Research suggests that they may play a role in many diseases, such as dementia, cardiovascular disease, and cancer.
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BYJUS
byjus.com › chemistry › free-radicals
Properties of Free Radicals
November 23, 2022 - ... In the body, oxygen breaks up into single atoms of unpaired electrons. Electrons prefer to be in pairs, and these atoms, known as free radicals, scavenge the body to look for other electrons so that they can become a pair.
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Physiopedia
physio-pedia.com › Free_Radicals
Free Radicals - Physiopedia
A free radical is atom or group of atoms that has at least one unpaired electron and is therefore unstable and highly reactive (often only occur as transientspecies). In animal tissues, free radicals can damage cells and are believed to accelerate the progression of cancer, cardiovascular ...
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C60
shopc60.com › home › what are free radicals? the facts you need to know
What are Free Radicals? The Facts You Need to Know - C60 Power
July 17, 2025 - Learn easy and accessible ways to slow or address free radical damage Free radicals are independent atoms with one or more unpaired electrons, making them highly reactive and unstable molecules.