Nattokinase has been promoted as an alternative anticancer treatment based on the notion that it can help dissolve the fibrin coating around a tumor, and increase oxygen supply in the blood to inhibit cancer cell growth.

Available evidence suggests that NK is a unique natural compound that possesses several key cardiovascular beneficial effects for patients with CVD and is therefore an ideal drug candidate for the prevention and treatment of CVD. Nattokinase is a promising alternative in the management of CVD.

Nattokinase might lower blood pressure. Taking nattokinase along with medications that lower blood pressure might cause blood pressure to go too low.

January 22, 2026 - Medically reviewed by Drugs.com. Last updated on Jan 22, 2026. Although nattokinase is promoted for use as a fibrinolytic and thrombolytic agent, clinical trials are lacking to support such use.

Nattokinase (NK), a potent blood-clot dissolving protein used for the treatment of cardiovascular diseases, is produced by the bacterium Bacillus subtilis during the fermentation of soybeans to produce Natto. NK has been extensively studied in Japan, Korea, and China.

June 24, 2026 - Explore how nattokinase, an enzyme from fermented soybeans, may aid heart and brain health. Understand its benefits and potential risks.

January 21, 2025 - It may be helpful in preventing blood clots and lowering blood pressure, but more research is needed to be sure. Nattokinase is also available as a supplement, but talk to your doctor first to see if it's right for you.

March 16, 2026 - Nattokinase is most often used for Cardiovascular Health.

September 28, 2024 - Find out what nutrients are in nattokinase and learn how it can help everything from heart disease prevention to improved gut health.

Based on the available clinical ... The second major finding was that nattokinase could be considered as a promising adjunctive tool in the treatment of hypertension....

November 25, 2025 - Nattokinase is used in the treatment of heart attack and pulmonary embolism. Most side effects do not require any medical attention and disappear as your body adjusts to the medicine.

July 20, 2026 - It is sold as a dietary supplement and is commonly advertised for blood flow, cardiovascular health, and “breaking down clots.” These claims sound straightforward, but the science is more limited than many supplement labels suggest.

June 16, 2023 - Nattokinase is an enzyme extracted from natto, a traditional Japanese food made from fermented soybeans that supports heart and blood health.

October 23, 2024 - NK has shown excellent anti-thrombus, thrombolytic, and anti-inflammation activities that potentially delay aging and provide therapeutic effects on aging-related diseases. In this review, we critically overview the experimental and clinical ...

December 12, 2025 - Their potency requires careful dosing and monitoring because excessive fibrinolysis can cause life-threatening bleeding. In contrast, nattokinase is taken orally as a supplement for cardiovascular maintenance rather than acute treatment (Weng ...

June 11, 2021 - Medications that slow blood clotting (Anticoagulant / Antiplatelet drugs)Interaction Rating: Moderate Be cautious with this combination.Talk with your health provider. Nattokinase can decrease blood clotting.

December 19, 2025 - The enzyme nattokinase appears to reduce clotting, protect against stroke, lower cholesterol, and more. Could it help you?

June 18, 2026 - Deep vein thrombosis prevention: One study examined a combination of nattokinase and Pycnogenol (pine bark extract) in men and women at high risk for deep vein thrombosis (DVT) who were not taking anticoagulant or anti-thrombotic medication.

August 7, 2026 - Compared to other fibrinolytic enzymes like serrapeptidase and lumbrokinase, nattokinase has the most published human clinical data for general cardiovascular support. Because it influences circulatory pathways, anyone on blood thinners or blood ...