Nattokinase has been promoted as an alternative anticancer treatment based on the notion that it can help dissolve the fibrin coating around a tumor, and increase oxygen supply in the blood to inhibit cancer cell growth.

January 22, 2026 - Medically reviewed by Drugs.com. Last updated on Jan 22, 2026. Although nattokinase is promoted for use as a fibrinolytic and thrombolytic agent, clinical trials are lacking to support such use.

January 21, 2025 - It may be helpful in preventing blood clots and lowering blood pressure, but more research is needed to be sure. Nattokinase is also available as a supplement, but talk to your doctor first to see if it's right for you.

Nattokinase might lower blood pressure. Taking nattokinase along with medications that lower blood pressure might cause blood pressure to go too low.

August 23, 2007 - Explore how nattokinase, an enzyme from fermented soybeans, may aid heart and brain health. Understand its benefits and potential risks.

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March 16, 2026 - Nattokinase is most often used for Cardiovascular Health.

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June 11, 2021 - Medications that slow blood clotting (Anticoagulant / Antiplatelet drugs)Interaction Rating: Moderate Be cautious with this combination.Talk with your health provider. Nattokinase can decrease blood clotting.

June 18, 2026 - Deep vein thrombosis prevention: One study examined a combination of nattokinase and Pycnogenol (pine bark extract) in men and women at high risk for deep vein thrombosis (DVT) who were not taking anticoagulant or anti-thrombotic medication.

September 28, 2024 - Find out what nutrients are in nattokinase and learn how it can help everything from heart disease prevention to improved gut health.

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June 16, 2023 - Nattokinase is an enzyme extracted from natto, a traditional Japanese food made from fermented soybeans that supports heart and blood health.

October 23, 2024 - NK has shown excellent anti-thrombus, thrombolytic, and anti-inflammation activities that potentially delay aging and provide therapeutic effects on aging-related diseases. In this review, we critically overview the experimental and clinical ...

February 1, 2021 - Reasons to take nattokinase include supporting circulation reducing blood clot risk and promoting heart and vascular health naturally.

December 19, 2025 - The enzyme nattokinase appears to reduce clotting, protect against stroke, lower cholesterol, and more. Could it help you?

2 weeks ago - Nattokinase is a proteolytic enzyme derived from fermented soybeans (natto) that may support cardiovascular health by breaking down fibrin, improving circulation, reducing blood viscosity, and modestly lowering mild hypertension.

May 24, 2025 - For patients with three highs and cardiovascular disease patients with combined drug therapy, NK does not increase the risk of additional adverse reactions and does not interfere with the effectiveness of conventional medications. Some studies also show that it can reduce the side effects of drugs, such as alleviating statin-induced liver injury. Nattokinase, as a natural bioactive substance derived from traditional fermented foods, has shown remarkable research results in the field of blood lipid reduction.