Oxytocin reduces amygdala responses to threatening social stimuli in males and has been suggested to facilitate approach-related processing by either …

August 1, 2015 - Our data provide evidence that oxytocin mediates this behavioral change by decreasing the anxiety response, coincident with decreased amygdala activation. However, previous work has shown that the reward circuitry of the nucleus accumbens plays a significant role in social behavior (Gunaydin ...

The amygdala is a key region in ... reported in aggression-prone individuals and the neuropeptide oxytocin (OT) could dampen anger-related amygdala reactivity in a number of mental disorders....

November 6, 2020 - Intranasal administration of the neuropeptide oxytocin (IN-OT) is increasingly considered as a potential treatment for targeting the core symptoms of autism spectrum disorder (ASD), but the effects of continual use on neural substrates are fairly unexplored and long-term effects are unknown.

March 7, 2022 - Effects on the amygdala may help to explain two of oxytocin’s broad effects, namely increased attention and orientation to social stimuli (Shamay-Tsoory and Abu-Akel, 2016) and reduced anxiety responses to social stimuli (Bethlehem et al., 2013, 2014). In light of its central role in social ...

March 16, 2020 - The ability to successfully regulate negative emotions such as fear and anxiety is vital for mental health. The neuropeptide oxytocin (OXT) acts as important modulator of emotion regulation, as reflected by reduced amygdala responses but increased amygdala–prefrontal cortex (PFC) functional ...

April 7, 2010 - Oxytocin (OT) is becoming increasingly established as a prosocial neuropeptide in humans with therapeutic potential in treatment of social, cognitive, and mood disorders. However, the potential of OT as a general facilitator of human learning and empathy is unclear.

August 2, 2015 - PDF | Standard dopamine therapies for schizophrenia are not efficacious for negative symptoms of the disease, including asociality. This reduced social... | Find, read and cite all the research you need on ResearchGate

We adopted a randomized, double-blind, ... of angry and happy face stimuli, with pairwise comparisons revealing reduced activation after the 8IU low dose intranasal treatment compared to placebo....

February 16, 2021 - Oxytocin (OT) orchestrates social and emotional behaviors through modulation of neural circuits. In the central amygdala, the release of OT modulates inhibitory circuits and, thereby, suppresses fear responses and decreases anxiety levels. Using astrocyte-specific gain and loss of function ...

Intranasal administration of the neuropeptide oxytocin (OXT) has been shown to reduce amygdala activity but to increase amygdala–prefrontal cortex connectivity during exposure to threatening stimuli suggesting that it may act as an important modulator of emotion regulation.

November 30, 2019 - Accumulating evidence suggests that intranasal oxytocin (OXT; 24 IU) reduces amygdala responses to fear-related stimuli in men, while exerting inverse effects in women. However, OXT enhances activity of the brain reward system in both sexes. Importantly, a crucial and still open question is ...

Figure 5. Correlation differences ... and oxytocin (OXT) groups. Data from EE and SE trials are combined. In both cases the correlation difference between the OXT and PLC groups is significant (Fisher's Z-test p < 0.05). The current experiment demonstrated for the first time that OXT increases both empathic- and self-embarrassment ratings in male and female subjects and that its behavioral effects are associated with decreased responses in the right amygdala and in the ...

December 12, 2017 - Oxytocin signaling plays a critical role in a molecularly defined neuronal population of the Medial Amygdala to modulate the behavioral and physiological responses of male mice to females on a moment-to-moment basis.

July 31, 2018 - Accumulating evidence suggests that the neuropeptide oxytocin (OXT) can enhance empathy although it is unclear which specific behavioral and neural aspects are influenced, and whether the effects are modulated by culture, sex, and trait autism. Based on previous findings in Caucasian men, we hypothesized that a single intranasal dose of OXT would specifically enhance emotional empathy (EE) via modulatory effects on the amygdala ...

June 13, 2017 - Oxytocin in the amygdala suppresses freezing of mothers when exposed to a threat in the presence of their offspring, allowing for pup protection and transmission of information about danger from mothers to pups.

March 22, 2010 - Given the overlap between the role of the amygdala and the influence of oxytocin on social cognition, we hypothesize that the effects of oxytocin on social behavior are mediated via interactions with the emotion-processing elements of the amygdala and its dopaminergic connections.

July 16, 2021 - From joy and attachment to anxiety and protectiveness, mothering behavior begins with biochemical reactions.