I might regret commenting, but honestly I think the biggest risk with glyphosate is in its effect on beneficial microorganisms (eg in the soil, our gut microbiome). I just want to add that a lot of this research is in the early days yet, and more studies are needed to prove causation. But at this time I'm erring on the side of caution when possible. "Overall, these findings suggest an intriguing correlation between glyphosate exposure, changes to the gut microbiome and abhorrent development of the GABAergic system, HPA-axis and the formation of microglial cells. Additionally, metabolism of glyphosate by the microbiome may alter NMDA receptor activation thereby promoting neuroinflammation in otherwise healthy individuals. Glyphosate-induced perturbations to the gastrointestinal microbiome may influence the synthesis of many neurotransmitters, necessary for mental health and wellbeing, encourage the formation of damaging ROS and reduce bacteria thought to be beneficial during times of stress. While the understanding of this correlation is still emerging, more research to prove or disprove this relationship is warranted given the food system is known to contain glyphosate residues." Barnett, Jacqueline A et al. “Is the Use of Glyphosate in Modern Agriculture Resulting in Increased Neuropsychiatric Conditions Through Modulation of the Gut-brain-microbiome Axis?.” Frontiers in nutrition vol. 9 827384. 8 Mar. 2022, doi:10.3389/fnut.2022.827384 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8959108/#abstract-a.e.b.ntitle The above article focuses on neuropsychiatic conditions, but the gut microbiome impacts other systems as well including the metabolic, immune, and obviously the digestive system. Here's another relevant study: "Glyphosate inhibits the shikimate pathway, a pathway exclusive to plants and bacteria. Glyphosate’s effect on dysbiosis was not considered when making safety recommendations. Here, we evaluate the literature surrounding glyphosate’s effects on the gut microbiome and conclude that glyphosate residues on food could cause dysbiosis, given that opportunistic pathogens are more resistant to glyphosate compared to commensal bacteria. However, research on glyphosate’s effects on the microbiome suffers from numerous methodological weaknesses, and these limitations make it impossible to draw any definitive conclusions regarding glyphosate’s influence on health through alterations in the gut microbiome" Barnett, Jacqueline A, and Deanna L Gibson. “Separating the Empirical Wheat From the Pseudoscientific Chaff: A Critical Review of the Literature Surrounding Glyphosate, Dysbiosis and Wheat-Sensitivity.” Frontiers in microbiology vol. 11 556729. 25 Sep. 2020, doi:10.3389/fmicb.2020.556729 (I realize both studies I mentioned have the same lead author. I think it's possible I just like her writing style, or that she's been the most prolific at writing reviews on this topic. I promise there are other people writing about this I'm just tired and undercaffeinated.) FWIW the proposed effects of glyphosate on bees is due to its effect on the bees' microbiome. Motta, E.V.S., Powell, J.E. & Moran, N.A. Glyphosate induces immune dysregulation in honey bees. anim microbiome 4, 16 (2022). https://doi.org/10.1186/s42523-022-00165-0 https://animalmicrobiome.biomedcentral.com/articles/10.1186/s42523-022-00165-0 (There we go, a different lead author!)