In the present study, we analyzed ... factors putatively linked to brain tumors, the artificial sweetener aspartame is a promising candidate to explain the recent increase in incidence and degree of malignancy of brain tumors....

Aspartame (NutraSweet, Equal, etc) is one of the most common artificial sweeteners in use today. Find out what we know about its safety here.

February 1, 1997 - Barnett's (Nov 23, p 1435)1 reference to a recent report suggesting aspartame (NutraSweet) products as a cause of brain tumours, and the “blitz of letters” from the manufacturer, warrants comment. There was no mention of more than a score of my publications over the past decade—including ...

July 14, 2023 - Citing “limited evidence” for carcinogenicity in humans, IARC classified aspartame as possibly carcinogenic to humans (IARC Group 2B) and JECFA reaffirmed the acceptable daily intake of 40 mg/kg body weight.

Six artificial sweeteners are approved ... sweetener to identify possible health harms. The results of these studies showed no evidence that these sweeteners cause cancer or other harms in people....

July 14, 2023 - In 1974, the FDA approved the use ... initial studies themselves. Some scientists were concerned when an early animal study showed that aspartame may have caused brain tumors in rats....

July 16, 1997 - James G. Gurney, Janice M. Pogoda, ... ( 1 ) and children ( 2 ). The possibility that aspartame, a widely ingested artificial sweetener, may be a cause of brain cancer ......

April 12, 2021 - Background Aspartame is one of ... women. The Ramazzini Institute (RI) reported in 2006 and 2007 that aspartame causes dose-related increases in malignant tumors in multiple organs in rats and mice....

January 29, 2022 - In July 2023, the International Agency for Research on Cancer (IARC) at the World Health Organization noted that aspartame is "possibly carcinogenic to humans" (Group 2B out of four levels) and advised that an acceptable daily intake of aspartame is 40 milligrams per kilogram of body weight.

September 1, 2006 - Abstract. Background: In a few animal experiments, aspartame has been linked to hematopoietic and brain cancers. Most animal studies have found no increase in the risk of these or other cancers. Data on humans are sparse for either cancer. Concern lingers regarding this widely used artificial ...

June 3, 2025 - In 1980, a Public Board of Inquiry (PBOI) heard testimony from Olney and disagreed with his claims that aspartame could cause brain damage, including in the developing fetus. The board decided that further study was needed on a postulated connection between aspartame and brain tumors, and revoked ...

July 14, 2023 - Jackie Goodrich, research associate professor of Environmental Health Sciences at the University of Michigan School of Public Health, discusses the World Health Organization's recent decision to classify the artificial sweetener as possibly carcinogenic while also maintaining the current ...

July 14, 2023 - When American pharmaceutical company ... to get aspartame approved by the FDA in 1973, it was denied: Independent scientists alleged the product could cause a range of neurologic disorders, and some alleged the company hadn’t been entirely above-board in its safety testing. In January 1981, Ronald Reagan became the US president. His transition team included then-CEO of G.D. Searle, one Donald Rumsfeld. Although an independent FDA board warned that May that the drug might induce brain tumors, the agency’s ...

January 10, 2025 - Artificial sweeteners are unlikely to cause cancer. Sugar doesn’t directly cause cancer, but eating too much sugar can make it harder to keep a healthy weight

The results of this mega-experiment indicate that aspartame, in the tested experimental conditions, is a multi-potential carcinogenic agent (Table 2). ... There are some remarkable contradictory results found in the epidemiological studies. Olney et al. (1996) reported the relationship between increasing frequency of brain tumors ...

Cancer Council encourages healthy eating and maintaining a healthy weight to help protect against cancer.

June 22, 2024 - For the average person, aspartame is not known to pose any serious risks or major side effects. To put it simply: Diet Coke is not associated with cancer.

July 13, 2023 - The agency put that decision on hold for years due to questions about the reliability of safety studies submitted by G.D. Searle on whether aspartame was linked to brain tumors. The FDA ultimately concluded there was reasonable certainty that aspartame did not cause brain tumors and authorized ...

August 1, 1997 - Under stomach conditions, nitrosation of the side-chains of certain Trp peptides would be expected to contribute more to the endogenous burden of nitrosated products than nitrosation of aspartame or Gly peptides. ... Brain tumors are the leading cause of death from childhood cancer, yet the ...

January 31, 2025 - The food additive aspartame is a sweetener used in many foods and drinks. Learn about potential side effects and safe daily amounts here.