Evidence potentially implicating aspartame includes an early animal study revealing an exceedingly high incidence of brain tumors in aspartame-fed rats compared to no brain tumors in concurrent controls, the recent finding that the aspartame ...

February 1, 1997 - Barnett's (Nov 23, p 1435)1 reference to a recent report suggesting aspartame (NutraSweet) products as a cause of brain tumours, and the “blitz of letters” from the manufacturer, warrants comment. There was no mention of more than a score of my publications over the past decade—including two books—in which I specifically raised this potential major public health threat.

Other large cohort studies have ... Diet and Health Study, in which higher consumption of aspartame-containing beverages was not associated with the development of lymphoma, leukemia, or brain cancer during more than 5 years of follow-up (12)....

September 1, 2006 - Additionally, a population-based case-control study found a null association between childhood brain tumors and aspartame intake among both children and their mothers during pregnancy and lactation (12).

There was no significant difference in the incidence of brain tumors between control and test groups. It is concluded that neither AMP nor DKP caused brain tumors in rats in this study.

July 16, 1997 - Brain cancer incidence rates in the United States have been increasing in both adults ( 1 ) and children ( 2 ). The possibility that aspartame, a widely ingested artificial sweetener, may be a cause of brain cancer in humans was suggested in ...

Conclusions: Our findings do not support the hypothesis that aspartame increases hematopoietic or brain cancer risk.

July 8, 2025 - However, aspartame can directly impact the gut microbiome and thus mediate glioblastoma risk via the gut-brain axis. This axis affects immunity and metabolic pathways in the tumor's immediate microenvironment.

April 23, 2026 - In 1996, researchers reported in the Journal of Neuropathology & Experimental Neurology on epidemiological evidence connecting the introduction of aspartame to an increase in an aggressive type of malignant brain tumors.

The criteria invoked in judging ... rats have a high incidence of malignant brain tumors; and 3) an increased incidence of brain tumors in humans following the introduction of aspartame in the diet....

July 20, 2023 - U.S. Food and Drug Administration ... that “studies do not suggest an increased risk associated with aspartame consumption for … a variety of cancers, including brain, lymphatic, and haematopoietic (blood) cancers.”...

March 21, 2019 - Evidence potentially implicating aspartame includes an early animal study revealing an exceedingly high incidence of brain tumors in aspartame-fed rats compared to no brain tumors in concurrent controls, the recent finding that the aspartame ...

January 1, 1997 - The criteria invoked in judging ... incidence of malignant brain tumors; and 3) an increased incidence of brain tumors in humans following the introduction of aspartame in the diet....

August 2, 2016 - *Ishii H (1981). Incidence of brain tumors in rats fed aspartame.

July 14, 2023 - For the first time, a semi-independent ... of products like diet sodas and sugar-free gum, should be categorized as “possibly carcinogenic to humans.” · But as alarming as the designation might sound, this label does not mean ...

October 28, 2020 - The possibility that aspartame had neuro-oncogenic potential was one of the major issues at the Public Board of Inquiry evaluating the safety of aspartame. Brain tumors in various rat strains have been recorded by commercial breeding companies, individual investigators, and governmental agencies.

November 18, 2002 - There was no significant difference in the incidence of brain tumors between control and test groups. It is concluded that neither APM nor DKP caused brain tumors in rats in this study. Check access to the full text by signing in through your organization.Access through your organization · B. Sass et al. ... U.S. Government Printing Office Aspartame

April 12, 2021 - The Ramazzini Institute (RI) reported in 2006 and 2007 that aspartame causes dose-related increases in malignant tumors in multiple organs in rats and mice. Increased cancer risk was seen even at low exposure levels approaching the Acceptable ...

January 29, 2022 - The NCI notes a 2006 study of the diets of 500,000 retirees found no connection between increased aspartame and lymphoma, leukemia or brain cancer.

November 24, 2025 - A key 1970s industry-sponsored study initially sparked concerns that aspartame caused brain tumors in rats, but the FDA convinced an independent review panel to reverse its conclusion that aspartame was unsafe.