PubMed
Increasing brain tumor rates: is there a link to aspartame? - PubMed
In the present study, we analyzed ... factors putatively linked to brain tumors, the artificial sweetener aspartame is a promising candidate to explain the recent increase in incidence and degree of malignancy of brain tumors....
Oxford Academic
Aspartame Consumption in Relation to Childhood Brain ...
July 16, 1997 - James G. Gurney, Janice M. Pogoda, ... ( 1 ) and children ( 2 ). The possibility that aspartame, a widely ingested artificial sweetener, may be a cause of brain cancer ......
Environmental Health
Aspartame and cancer – new evidence for causation | Environmental Health | Full Text
Background Aspartame is one of ... women. The Ramazzini Institute (RI) reported in 2006 and 2007 that aspartame causes dose-related increases in malignant tumors in multiple organs in rats and mice....
The Lancet
Aspartame and brain cancer - The Lancet
Barnett's (Nov 23, p 1435)1 reference to a recent report suggesting aspartame (NutraSweet) products as a cause of brain tumours, and the “blitz of letters” from the manufacturer, warrants comment. There was no mention of more than a score of my publications over the past decade—including ...
WHO
Aspartame hazard and risk assessment results released
July 14, 2023 - Citing “limited evidence” for carcinogenicity in humans, IARC classified aspartame as possibly carcinogenic to humans (IARC Group 2B) and JECFA reaffirmed the acceptable daily intake of 40 mg/kg body weight.
American Cancer Society
Aspartame and Cancer Risk | American Cancer Society
Aspartame (NutraSweet, Equal, etc) is one of the most common artificial sweeteners in use today. Find out what we know about its safety here.
NCI
Artificial Sweeteners and Cancer - NCI
Six artificial sweeteners are approved ... sweetener to identify possible health harms. The results of these studies showed no evidence that these sweeteners cause cancer or other harms in people....
City of Hope
Aspartame and Cancer Risk: What’s the Link?
January 29, 2022 - In July 2023, the International Agency for Research on Cancer (IARC) at the World Health Organization noted that aspartame is "possibly carcinogenic to humans" (Group 2B out of four levels) and advised that an acceptable daily intake of aspartame is 40 milligrams per kilogram of body weight.
American Association for Cancer Research
Consumption of Aspartame-Containing Beverages and Incidence of Hematopoietic and Brain Malignancies | Cancer Epidemiology, Biomarkers & Prevention | American Association for Cancer Research
September 19, 2006 - Abstract. Background: In a few animal experiments, aspartame has been linked to hematopoietic and brain cancers. Most animal studies have found no increase in the risk of these or other cancers. Data on humans are sparse for either cancer. Concern lingers regarding this widely used artificial ...
CNN
WHO declares widely used sweetener aspartame a possible cancer cause, but intake guidelines stay the same | CNN
July 14, 2023 - In 1974, the FDA approved the use ... initial studies themselves. Some scientists were concerned when an early animal study showed that aspartame may have caused brain tumors in rats....
PubMed
Consumption of aspartame-containing beverages and incidence of hematopoietic and brain malignancies - PubMed
Background: In a few animal experiments, aspartame has been linked to hematopoietic and brain cancers. Most animal studies have found no increase in the risk of these or other cancers. Data on humans are sparse for either cancer.
CA
Aspartame Cancer Prioritization 2016
August 2, 2016 - We cannot provide a description for this page right now
ScienceDirect

Artificial sweeteners—do they bear a carcinogenic risk? - ScienceDirect
Artificial sweeteners are added to a wide variety of food, drinks, drugs and hygiene products. Since their introduction, the mass media have reported …
Pediatricneurologybriefs
Aspartame and Brain Tumor Risk | Pediatric Neurology Briefs
The potential link of aspartame to rising brain tumor rates was analyzed using 1975 to 1992 data from the US National Cancer Institute in a study at the Departments of Psychiatry and Biostistics, Washington University Medical School, St Louis, MO.
ScienceDirect

Evaluation of aspartame cancer epidemiology studies based on quality appraisal criteria - ScienceDirect
Given the widespread use of the low-calorie sweetener aspartame over the last 30 years, the current work was undertaken to evaluate aspartame epidemio…
University of Michigan School of Public Health
Aspartame and cancer: A toxicologist's take |
July 14, 2023 - Jackie Goodrich, research associate professor of Environmental Health Sciences at the University of Michigan School of Public Health, discusses the World Health Organization's recent decision to classify the artificial sweetener as possibly carcinogenic while also maintaining the current ...
Vox
The WHO declared aspartame “possibly” causes cancer. Here’s what that means.
July 14, 2023 - When American pharmaceutical company ... to get aspartame approved by the FDA in 1973, it was denied: Independent scientists alleged the product could cause a range of neurologic disorders, and some alleged the company hadn’t been entirely above-board in its safety testing. In January 1981, Ronald Reagan became the US president. His transition team included then-CEO of G.D. Searle, one Donald Rumsfeld. Although an independent FDA board warned that May that the drug might induce brain tumors, the agency’s ...
Oxford Academic
Increasing Brain Tumor Rates: Is There a Link to Aspartame?
November 1, 1996 - Abstract. In the past two decades brain tumor rates have risen in several industrialized countries, including the United States. During this time, brain tu
Wikipedia
Aspartame controversy - Wikipedia
June 3, 2025 - In 1980, a Public Board of Inquiry (PBOI) heard testimony from Olney and disagreed with his claims that aspartame could cause brain damage, including in the developing fetus. The board decided that further study was needed on a postulated connection between aspartame and brain tumors, and revoked ...
MD Anderson Cancer Center
Do artificial sweeteners cause cancer? | MD Anderson Cancer Center
July 18, 2023 - Do artificial sweeteners cause cancer? We went to Ernest Hawk, M.D., vice president and head of Cancer Prevention and Population Sciences, for answers.