Evidence potentially implicating aspartame includes an early animal study revealing an exceedingly high incidence of brain tumors in aspartame-fed rats compared to no brain tumors in concurrent controls, the recent finding that the aspartame ...

September 1, 2006 - Abstract. Background: In a few animal experiments, aspartame has been linked to hematopoietic and brain cancers. Most animal studies have found no increase in the risk of these or other cancers.

Other large cohort studies have ... Diet and Health Study, in which higher consumption of aspartame-containing beverages was not associated with the development of lymphoma, leukemia, or brain cancer during more than 5 years of follow-up (12)....

July 16, 1997 - Brain cancer incidence rates in the United States have been increasing in both adults ( 1 ) and children ( 2 ). The possibility that aspartame, a widely ingested artificial sweetener, may be a cause of brain cancer in humans was suggested in ...

February 1, 1997 - Barnett's (Nov 23, p 1435)1 reference to a recent report suggesting aspartame (NutraSweet) products as a cause of brain tumours, and the “blitz of letters” from the manufacturer, warrants comment. There was no mention of more than a score of my publications over the past decade—including two books—in which I specifically raised this potential major public health threat.

March 27, 2025 - John Olney, lead author of the study, told 60 minutes in 1996: “there has been a striking increase in the incidence of malignant brain tumors (in the three to five years following the approval of aspartame) …

Conclusions: Our findings do not support the hypothesis that aspartame increases hematopoietic or brain cancer risk.

July 8, 2025 - However, aspartame can directly impact the gut microbiome and thus mediate glioblastoma risk via the gut-brain axis. This axis affects immunity and metabolic pathways in the tumor's immediate microenvironment.

The criteria invoked in judging ... rats have a high incidence of malignant brain tumors; and 3) an increased incidence of brain tumors in humans following the introduction of aspartame in the diet....

The brain tumorigenicity of aspartame (APM) and of its diketopiperazine (DKP) was studied in 860 SCL Wistar rats. APM at dietary levels of 1 g/kg, 2 gK/, 4 g/kg or APM + DKP (3:1) 4 g/kg was fed for 104 weeks. One atypical astrocytoma was found in a control rat and 2 astrocytomas, 2 oligodendrogliom …

November 18, 2002 - The brain tumorigenicity of aspartame (APM) and of its diketopiperazine (DKP) was studied in 860 SLC Wistar rats. APM at dietary levels of 1 g/kg, 2 g…

July 20, 2023 - U.S. Food and Drug Administration ... that “studies do not suggest an increased risk associated with aspartame consumption for … a variety of cancers, including brain, lymphatic, and haematopoietic (blood) cancers.”...

November 24, 2025 - A key 1970s industry-sponsored study initially sparked concerns that aspartame caused brain tumors in rats, but the FDA convinced an independent review panel to reverse its conclusion that aspartame was unsafe.

March 21, 2019 - Evidence potentially implicating aspartame includes an early animal study revealing an exceedingly high incidence of brain tumors in aspartame-fed rats compared to no brain tumors in concurrent controls, the recent finding that the aspartame ...

October 28, 2020 - The possibility that aspartame had neuro-oncogenic potential was one of the major issues at the Public Board of Inquiry evaluating the safety of aspartame. Brain tumors in various rat strains have been recorded by commercial breeding companies, individual investigators, and governmental agencies.

In addition, in epidemiological studies the percentage of the positive results was lower than in animal models. Nearly 45 % of the existing results yielded as positive. Brain tumor, NHL, leukemia, urinary tract tumors and multiple myeloma were reported in three articles.

November 1, 1996 - Evidence potentially implicating aspartame includes an early animal study revealing an exceedingly high incidence of brain tumors in aspartame-fed rats compared to no brain tumors in concurrent controls, the recent finding that the aspartame ...

July 14, 2023 - In 1974, the FDA approved the use of aspartame in some foods and beverages, but the decision was suspended for a few years because of some contradictory studies, objections to its approval and questions about the initial studies themselves. Some scientists were concerned when an early animal study showed that aspartame may have caused brain tumors in rats.

January 1, 1997 - The criteria invoked in judging ... incidence of malignant brain tumors; and 3) an increased incidence of brain tumors in humans following the introduction of aspartame in the diet....

April 12, 2021 - A particularly important use is ... Institute (RI) reported in 2006 and 2007 that aspartame causes dose-related increases in malignant tumors in multiple organs in rats and mice....