Evidence potentially implicating aspartame includes an early animal study revealing an exceedingly high incidence of brain tumors in aspartame-fed rats compared to no brain tumors in concurrent controls, the recent finding that the aspartame ...

July 16, 1997 - Brain cancer incidence rates in the United States have been increasing in both adults ( 1 ) and children ( 2 ). The possibility that aspartame, a widely ingested artificial sweetener, may be a cause of brain cancer in humans was suggested in ...

Other large cohort studies have ... Diet and Health Study, in which higher consumption of aspartame-containing beverages was not associated with the development of lymphoma, leukemia, or brain cancer during more than 5 years of follow-up (12)....

September 1, 2006 - Abstract. Background: In a few animal experiments, aspartame has been linked to hematopoietic and brain cancers. Most animal studies have found no increase in the risk of these or other cancers.

Conclusions: Our findings do not support the hypothesis that aspartame increases hematopoietic or brain cancer risk.

November 18, 2002 - The brain tumorigenicity of aspartame (APM) and of its diketopiperazine (DKP) was studied in 860 SLC Wistar rats. APM at dietary levels of 1 g/kg, 2 g…

April 12, 2021 - A particularly important use is ... Institute (RI) reported in 2006 and 2007 that aspartame causes dose-related increases in malignant tumors in multiple organs in rats and mice....

March 28, 2025 - John Olney, lead author of the study, told 60 minutes in 1996: “there has been a striking increase in the incidence of malignant brain tumors (in the three to five years following the approval of aspartame) …

July 14, 2023 - In 1974, the FDA approved the use of aspartame in some foods and beverages, but the decision was suspended for a few years because of some contradictory studies, objections to its approval and questions about the initial studies themselves. Some scientists were concerned when an early animal study showed that aspartame may have caused brain tumors in rats.

The quantitative data on aspartame carcinogenicity in animal models are summarized in Table 2. A total of 11 assessments were reported in five articles. Among them the percentage of the positive results was 73 %. Brain, prostate, breast tumors, lymphoma, leukemia, cell carcinoma of the renal pelvis and ureter, malignant schwannomas of peripheral nerves were observed in rats.

January 29, 2022 - The NCI notes a 2006 study of the diets of 500,000 retirees found no connection between increased aspartame and lymphoma, leukemia or brain cancer.

January 1, 1997 - The criteria invoked in judging ... incidence of malignant brain tumors; and 3) an increased incidence of brain tumors in humans following the introduction of aspartame in the diet....

July 14, 2023 - After all, there are several as-yet unexplained emerging cancer trends, like rising rates of colon cancers in young adults, and increasing brain tumor rates in children and teens.

June 3, 2025 - In 1981, FDA Commissioner Arthur Hull Hayes sought advice on the issue from a panel of FDA scientists and a lawyer. The panel identified errors underlying the PBOI conclusion that aspartame might cause brain tumors, and presented arguments both for and against approval.

February 2, 2019 - Overall, the results of the studies do not support that exposures to low and no-calorie sweeteners and beverages, and by extension aspartame, are associated with an increased risk of cancer in humans.

July 8, 2025 - Study shows aspartame affects gut microbiome and gene expression in glioblastoma, highlighting potential links to cancer progression and treatment strategies.

July 2, 2025 - The WHO stated that while current evidence suggests aspartame is safe at typical consumption levels, potential effects need further investigation through comprehensive studies. Glioblastoma (GBM) is the most aggressive and lethal type of primary brain tumor, characterized by its rapid growth, resistance to conventional therapies, and a highly immunosuppressive tumor microenvironment11,12.

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