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For example, compounds from the family Zingiberaceae, such as turmeric (Curcuma longa), and tamarind (Tamarindus indica), have been used to cure several diseases caused by pathogenic microorganisms, including diarrhea and dysentery (30, 31). Few studies have investigated the anti-infective properties of medicinal plants, despite numerous recent ethnobotanical surveys indicating their use by individuals to mitigate infectious ailments (32, 33). Many other studies have conducted targeted studies on the beneficial effects of compounds derived from medicinal plants, such as anti-Candida agents (34), anti-biofilm agents (35), and inhibitors of resistant microbial isolates (36).

By reactivating these silenced genes, sulforaphane promotes anti‐cancer activity, offering a preventive and therapeutic approach to cancer management (Sailo et al. 2024). Similarly, curcumin, a key bioactive compound in turmeric, influences histone acetylation, a process that enhances gene expression while suppressing oncogenes.

April 17, 2023 - Phytobioactive compounds are plant secondary metabolites and bioactive compounds abundantly present in medicinal plants and have remarkable therapeutic potential. Oxidative stress and antibiotic resistance are major causes of present-day ailments ...

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Natural compounds, or their semi-synthetic derivatives obtained from plants, have contributed to the development of drugs against microbial diseases and various human ailments. For instance, artemisinin, a sesquiterpene lactone obtained from Artemisia annua, is used as a therapeutic agent for ...

Natural bioactive compounds encompass a vast array of molecules derived from plants, fungi, marine organisms, and other natural sources [1]. Their biological activities range from antioxidant and anti-inflammatory properties to antimicrobial and anticancer effects, reflecting their potential ...

April 4, 2023 - Plant-derived natural compounds have been implemented in clinics against microbial diseases. Unfortunately, the emergence of antimicrobial resistance has significantly reduced the efficacy of ...

The data presented in these articles is particularly intriguing, highlighting the potential of plant metabolites and their extracts in the treatment of neurological disorders such as Alzheimer’s disease, cancer, and diabetes mellitus. The findings provide valuable insights into the therapeutic properties of these phytochemicals and their potential applications in tackling these challenging health conditions. The research conducted in these articles offers promising avenues for the development of novel treatment approaches and interventions using natural compounds derived from plants.

10.Riaz M., Khalid R., Afzal M., Anjum F., Fatima H., Zia S., Rasool G., Egbuna C., Mtewa A.G., Uche C.Z., et al. Phytobioactive Compounds as Therapeutic Agents for Human Diseases: A Review. Food Sci. Nutr. 2023;11:2500–2529. doi: 10.1002/fsn3.3308.

The main focus of this mini-review is to highlight the potential benefits of plant derived multiple compounds and the importance of phytochemicals for the development of biocompatible therapeutics. In addition, this review focuses on the diverse effects and efficacy of herbal compounds in controlling the development of MDR in microbes and hopes to inspire research into unexplored plants with a view to identify novel antibiotics for global health benefits. Keywords: antibiotics, infectious disease, antimicrobial resistant, secondary metabolites, immune response

Plant-derived bioactive phytochemicals have long been used, either singly or in combination, effectively against different life-threatening infectious diseases. Several studies have proposed that natural compounds can potentiate the activity of existing antibiotics and antifungal drugs.

Additionally, Ginsenoside Rh4 demonstrated the ability to inhibit the migration and invasion of gastric cancer cells in vivo by reversing epithelial–mesenchymal transition induced by the suppression of the TGF-β/Smad2/3 signaling axis [11,12]. Furthermore, another phytochemical compound, sesquiterpenoid zerumbone, exerted therapeutic effects on adult mouse microglia by reducing the expression of lipocalin-2 as well as pro-inflammatory cytokines (interleukin-6 and -1β and tumor necrosis factor-α) and chemokines (CCL-2 and CXCL-10).

Scientists are in search of new phytochemicals that could be developed as useful anti-microbials for treatment of infectious diseases. Currently, out of 80% of pharmaceuticals derived …

SE suppresses LPS-stimulated inflammatory markers at the transcription and translation levels. The targeting of ER stress is possibly another mechanism underlying its anti-inflammatory potential. These findings reveal the potential of SE as being a beneficial therapeutic for inflammation and ...

Keywords: antimicrobial activity, bioactive compounds, plant derivatives, human microbiota, antibiotics, antioxidants, inflammatory diseases, medicinal plants, new antimicrobials · Plant-derived compounds refer to materials or ingredients that originate from plants. They are secondary metabolites that are involved in the response to exogenous stressors. In the years 75–45 BC, Pedanius Dioscorides (who lived in the first century A.D.) wrote an encyclopedia called De Materia Medica, in which he described 600 therapeutic medicinal plants in the form of a series of scientific research [1]. Since then, a high number of herbal drugs have been recognized as potential therapeutic agents.