April 17, 2023 - Phytobioactive compounds are plant secondary metabolites and bioactive compounds abundantly present in medicinal plants and have remarkable therapeutic potential. Oxidative stress and antibiotic resistance are major causes of present-day ailments ...

For example, compounds from the family Zingiberaceae, such as turmeric (Curcuma longa), and tamarind (Tamarindus indica), have been used to cure several diseases caused by pathogenic microorganisms, including diarrhea and dysentery (30, 31). Few studies have investigated the anti-infective properties of medicinal plants, despite numerous recent ethnobotanical surveys indicating their use by individuals to mitigate infectious ailments (32, 33). Many other studies have conducted targeted studies on the beneficial effects of compounds derived from medicinal plants, such as anti-Candida agents (34), anti-biofilm agents (35), and inhibitors of resistant microbial isolates (36).

By reactivating these silenced genes, sulforaphane promotes anti‐cancer activity, offering a preventive and therapeutic approach to cancer management (Sailo et al. 2024). Similarly, curcumin, a key bioactive compound in turmeric, influences histone acetylation, a process that enhances gene expression while suppressing oncogenes.

April 17, 2023 - Phytobioactive compounds are plant secondary metabolites and bioactive compounds abundantly present in medicinal plants and have remarkable therapeutic potential. Oxidative stress and antibiotic resistance are major causes of present-day ailments ...

April 4, 2023 - Plant-derived natural compounds have been implemented in clinics against microbial diseases. Unfortunately, the emergence of antimicrobial resistance has significantly reduced the efficacy of ...

Natural bioactive compounds encompass a vast array of molecules derived from plants, fungi, marine organisms, and other natural sources [1]. Their biological activities range from antioxidant and anti-inflammatory properties to antimicrobial and anticancer effects, reflecting their potential ...

Scientists are in search of new phytochemicals that could be developed as useful anti-microbials for treatment of infectious diseases. Currently, out of 80% of pharmaceuticals derived …

10.Riaz M., Khalid R., Afzal M., Anjum F., Fatima H., Zia S., Rasool G., Egbuna C., Mtewa A.G., Uche C.Z., et al. Phytobioactive Compounds as Therapeutic Agents for Human Diseases: A Review. Food Sci. Nutr. 2023;11:2500–2529. doi: 10.1002/fsn3.3308.

The aim of this narrative review is to illustrate the potential of bioactive plant compounds, pro-resolving anti-inflammatory lipids, and statins as potential therapeutic agents for the treatment of IVDD and LBP.

They exert effects such as antioxidants, anti-inflammatories, antimicrobials, and immunomodulator agents [1]. These properties have made these compounds a focus of interest in health and disease prevention [2]. Polyphenols, found in fruits and vegetables, act as antioxidants with therapeutic ...

Modern drug discovery methods provide insight into the mechanisms underlying phytochemical action towards drug resistance, thus adding to our understanding of such diseases. Advanced analytical methods that help isolate, identify, and characterise potential compounds have recently been applied. Furthermore, combining separation and detection methods through hyphenated approaches such as LC-MS and LC-NMR are efficient in streamlining compound identification (Figure 9) [121,122,123]. Computational approaches have emerged as an effective means of identifying and optimising phytochemical therapeutics.

Natural compounds, or their semi-synthetic derivatives obtained from plants, have contributed to the development of drugs against microbial diseases and various human ailments. For instance, artemisinin, a sesquiterpene lactone obtained from Artemisia annua, is used as a therapeutic agent for ...

Nowadays, foods containing phytochemicals as a constituent (functional foods) and the concentrated form of phytochemicals (nutraceuticals) are used as a preventive measure or cure for many diseases. The health benefits of these phytochemicals depend on their purity and structural stability.

SE suppresses LPS-stimulated inflammatory markers at the transcription and translation levels. The targeting of ER stress is possibly another mechanism underlying its anti-inflammatory potential. These findings reveal the potential of SE as being a beneficial therapeutic for inflammation and ...

Since ancient times, plants have been a major source of novel drug molecules and have been used in the treatment of different infectious diseases. Secondary plant metabolites have miraculous healing properties and show potent therapeutic responses when used in combination drug therapy. The prime objective of this review is to summarize the concept of drug combination with special emphasis on the synergistic interactions between plant-derived bioactive phytochemicals with commercially available antimicrobial agents.

The main focus of this mini-review is to highlight the potential benefits of plant derived multiple compounds and the importance of phytochemicals for the development of biocompatible therapeutics. In addition, this review focuses on the diverse effects and efficacy of herbal compounds in controlling the development of MDR in microbes and hopes to inspire research into unexplored plants with a view to identify novel antibiotics for global health benefits. Keywords: antibiotics, infectious disease, antimicrobial resistant, secondary metabolites, immune response

Keywords: antimicrobial activity, bioactive compounds, plant derivatives, human microbiota, antibiotics, antioxidants, inflammatory diseases, medicinal plants, new antimicrobials · Plant-derived compounds refer to materials or ingredients that originate from plants. They are secondary metabolites that are involved in the response to exogenous stressors. In the years 75–45 BC, Pedanius Dioscorides (who lived in the first century A.D.) wrote an encyclopedia called De Materia Medica, in which he described 600 therapeutic medicinal plants in the form of a series of scientific research [1]. Since then, a high number of herbal drugs have been recognized as potential therapeutic agents.