Intra-body transmission networks are proposed to be composed of nanostructured or micro-sized detectors placed within the body to monitor health and distribute drugs. Transplanted biosensors are the potential options for monitoring the body for the detection of particular ailments and determining ...

April 9, 2024 - The significance of point-of-care testing (POCT) in early clinical diagnosis and personalized patient care is increasingly recognized as a crucial tool in re...

October 5, 2020 - Synonyms: single domain antibody ... (hcAB). These are produced in cell culture or in bacteria. Intrabody The cDNA of this probe is expressed in the cells for intracellular antigen targeting....

Rapid, efficient, simple approaches for biological nanoparticle recovery from bodily fluids are required for translating detection strategies from lab diagnostics to low-resource settings, where expensive sample processing instruments such as an ...

November 1, 2023 - Summary: In this Review we briefly summarize the basis for the development of nanobodies and provide an overview of the multiple applications of these versatile binders in biological research.

In biomedical research, there is an ongoing demand for new technologies to elucidate disease mechanisms and develop novel therapeutics. This requires comprehensive understanding of cellular processes and their pathophysiology based on reliable ...

Nanoscale systems have increasingly been used in biomedical applications, enhancing the demand for the development of biomolecule-functionalized nanoparticles for targeted applications. Such designer nanosystems hold great prospective to refine disease diagnosis and treatment.

We review the progress achieved during the recent five years in immunochemical biosensors (immunosensors) combined with nanoparticles for enhanced sensitivity. The initial part introduces antibodies as classic recognition elements. The optical sensing part describes fluorescent, luminescent, ...

June 10, 2020 - The development of targeted medicine has greatly expanded treatment options and spurred new research avenues in cancer therapeutics, with monoclonal antibodi...

With the recent advancement of nanomaterials and nanostructured materials, the point-of-care biosensor devices have shown a potential growth to revolutionize the future personalized health care diagnostics and therapy practices. This chapter deals ...

January 19, 2021 - Nanobodies are the recombinant variable domains of heavy-chain-only antibodies, with many unique properties such as small size, excellent solubility, superior stability, quick clearance from blood, and deep tissue penetration. As a result, nanobodies have become a promising tool for the diagnosis ...

October 26, 2024 - Nanobodies (Nbs) are antibody fragments derived from heavy-chain-only IgG antibodies found in the Camelidae family as well as cartilaginous fish. Their unique structural and functional properties, such as their small size, the ability to be engineered for high antigen-binding affinity, stability ...

One of the major challenges in medicine is the rapid and accurate measurement of protein biomarkers, cells, and pathogens in biological samples. A number of new diagnostic platforms have recently been developed to measure biomolecules and cells with high sensitivity that could enable early ...

Biosensors are modern engineering tools that can be widely used for various technological applications. In the recent past, biosensors have been widely used in a broad application spectrum including industrial process control, the military, ...

1 month ago - The increasing global prevalence of non-communicable diseases (NCDs) such as diabetes, cardiovascular disorders, and cancer poses a significant challe…

June 4, 2020 - Tumor-derived extracellular vesicles have emerged as an alternative source of cancer biomarkers in liquid biopsies. Despite their clinical potential, traditional methods for isolation and analysis have hampered their translation into the clinic. The use of nanomaterial-based biosensors can ...

Medical diagnosis has been greatly improved thanks to the development of new techniques capable of performing very sensitive detection and quantifying certain parameters. These parameters can be correlated with the presence of specific molecules and ...

Viruses are real menace to human safety that cause devastating viral disease. The high prevalence of these diseases is due to improper detecting tools. Therefore, there is a remarkable demand to identify viruses in a fast, selective and accurate ...

However, current techniques used ... be performed simultaneously as part of multiplex assays. This project therefore explores the use of fluorescent biosensors as novel strategies for the detection and identification of body fluids....