December 6, 2019 - The high specifity of DNA can be used to design nanomachines with high specificity by using specific DNA sequences.

Dynamic nanopores are promising tools for various biomedical applications. Here, the authors report on a triangular DNA nanopore that can switch in-situ between contracted and expanded states and provide low-noise repeatable signals in molecular sensing.

December 13, 2020 - DNA nanotechnology is an effective tool to combine DNA with nanomaterials for the fabrication of various nanoscale devices and nanostructures with pot…

Especially, nanomachines made of discrete numbers of molecular components can perform intended mechanical movements in a predetermined manner. Utilizing free energies of Watson-Crick base pairing, different types of DNA nanomachines have been invented to operate intended stepwise or autonomous ...

We are learning to build synthetic molecular machinery from DNA. This research is inspired by biological systems in which individual molecules act, singly and in concert, as specialized machines: our ambition is to create new technologies to perform tasks that are currently beyond our reach.

March 3, 2023 - Au-DNA self-assembled nanomachines can perform intelligent tasks such as sensing biomarkers and delivery of drug molecules through rational customizat…

In this work, we proposed a DNA nanomachine with multitentacles based on the multivalent effect and confirmed that the processing efficiency of multitentacles is much higher than that of a single tentacle by kinetic experiments. Interestingly, a multitentacle DNA nanomachine enables stable ...

The Scientist's content tagged with: DNA Nanomachine.

November 25, 2003 - Making DNA blink: A molecular machine based on the DNA i-motif structure is driven by changing pH (see picture). At pH 5, oligonucleotide X* folds into the i-motif (closed state), and complementary strand Y adopts a random-coil structure. At pH 8, X* unfolds and forms an extended duplex with Y.

May 1, 2018 - The cell membrane features a variety of heterogeneous and dynamic compartments to regulate cell structure and function. These compartments are generally cl

An elegant, highly integrated DNA nanomachine powered by endogenous ATP molecules was developed for specific microRNA imaging in living cells.

We combine patented intracellular analytics using DNA nanoprobes with AI to diagnose Alzheimer's Disease before symptoms manifest.

March 28, 2024 - Energy metabolism is highly interdependent with adaptive cell migration in vivo. Mechanical confinement is a critical physical cue that induces swi...

July 20, 2023 - Abstract Membrane curvature reflects physical forces operating on the lipid membrane, which plays important roles in cellular processes. Here, we design a mechanosensitive DNA (MSD) nanomachine tha...

September 20, 2023 - This study presents a unique peroxidase-like DNA-nanomachine (PxDm)-based nucleic acid detection technique that could transform healthcare through providing rapid and accurate identification of infectious diseases at the point-of-care (POC) format. A fragment of S.aureus bacterium genome, ...

Since light does not contaminate the reaction system, a DNA nanomachine run by a photon engine can overcome the drawback of waste that is a problem with molecular-fueled engines.There are several photoresponsive molecules that convert light energy to mechanical motion through the change of ...

May 26, 2020 - DNA nanomachines are capable of converting tiny triggers into autonomous accelerated cascade hybridization reactions and they have been used as a signal amplification strategy for intracellular imaging. However, the “always active” property of most DNA nanomachines with an “absolute ...

New DNA motor breaks speed record for nano machines: Scientists pave way for 'nano bots' to one day treat and diagnose disease

January 16, 2017 - The construction of DNA nanomachines holds great significance in the development of DNA nanostructures; however, the real application of nanomachines is still in its early stage. Moreover, one-step regenerated sensing platforms for the detection of biomarkers in the current research remain ...

An international team of scientists has recently developed a novel type of nano-engine made of DNA. It is driven by a clever mechanism and can perform pulsing movements. The researchers are now planning to fit it with a coupling and install it as a drive in complex nanomachines.