DNA nanomachines are nanorobots made entirely or partially of DNA.

It assembles all components on a single gold nanoparticle (AuNP) including a hairpin-locked swing arm encoding a start triggered by an intracellular target molecule and a two-stranded DNA track responding to the motion of the swing arm. When the intracellular target activates the nanomachine via the unlocking swing arm, the machine autonomously and progressively operates on the established DNA track via intramolecular toehold-mediated strand migration and internal ATP binding.

December 6, 2019 - The high specifity of DNA can be used to design nanomachines with high specificity by using specific DNA sequences.

DNA nanomachines are made by self-assembly, using techniques that rely on the sequence-specific interactions that bind complementary oligonucleotides together in a double helix. They can be activated by interactions with specific signalling ...

In this work, we proposed a DNA nanomachine with multitentacles based on the multivalent effect and confirmed that the processing efficiency of multitentacles is much higher than that of a single tentacle by kinetic experiments. Interestingly, a multitentacle DNA nanomachine enables stable ...

ConspectusDNA is regarded as an excellent nanomaterial due to its supramolecular property of duplex formation through A–T and G–C complementary pairs. By simply designing sequences, we can create any desired 2D or 3D nanoarchitecture with DNA. Based on these nanoarchitectures, motional DNA-based nanomachines have also been developed.

February 23, 2018 - It assembles all components on a single gold nanoparticle (AuNP) including a hairpin-locked swing arm encoding a start triggered by an intracellular target molecule and a two-stranded DNA track responding to the motion of the swing arm. When the intracellular target activates the nanomachine via the unlocking swing arm, the machine autonomously and progressively operates on the established DNA track via intramolecular toehold-mediated strand migration and internal ATP binding.

This research is inspired by biological ... nanomachines are made by self-assembly, using techniques that rely on the sequence-specific interactions that bind complementary oligonucleotides together in a double helix....

DNA tweezers, DNA origami actuators, DNA walkers, and DNA machine-enabled bulk sensing are discussed including structural motif design, toehold creations for strands displacement reactions, and other input forces, as well as examples of biological motor-driven hybrid nanomachines.

December 13, 2020 - DNA nanotechnology is an effective tool to combine DNA with nanomaterials for the fabrication of various nanoscale devices and nanostructures with potential performance in drug delivery and their biosensing assay. The development of DNA nanotechnologies, such as DNA nanomachines as smart carriers has been attracting increasing attention due to their small sizes, predictable secondary structures, and high biocompatibility.

March 28, 2024 - How energy supply and migration modes jointly coordinate to drive metastatic escape when facing mechanical challenges remains largely unknown. Herein, we design DNA nanomachines to precisely study mitochondrial distribution and ATP expression of individual migrating cells during distinct migration modes.

DNA nanomachines, a variety of self-assembly structures by artificial design, can move and change conformation upon stimulation by external triggers. (1) In the last 10 years, DNA nanomachines have received great interest due to their potential ...

Herein, we report a DNA nanomachine, built from a DNA-functionalized gold nanoparticle (DNA–AuNP), which moves a DNA walker along a three-dimensional (3-D) DNA–AuNP track and executes the task of releasing payloads. The movement of the DNA walker is powered by a nicking endonuclease that cleaves specific DNA substrates on the track.

Yuki Suzuki (Mie University) and Dr. Ibuki Kawamata (Tohoku University), the four lecturers effectively covered the basics of DNA nanomachine design, evaluation and analysis; along with practical tools for designing, simulation and visualisation to ten participants.

DNA nanomachines, which are designable and switchable nanostructures made of DNA, show broad potential to detect tumor biomarkers with noninvasive, inexpensive, highly sensitive, and highly specific advantages.

DNA nanomachines, one of the dynamic ... actuation.8,9 DNA nanomachines are molecular machines that integrate external triggers responding mechanisms with DNA structures as the basic components by relying on DNA sequence-specific interactions.10,11...

The new DNA motor is rod-shaped and uses RNA fuel to roll persistently in a straight line, without human intervention, at speeds up to 100 nanometers per minute.

A highly loaded and integrated core–brush three-dimensional (3D) DNA nanostructure is constructed by programmatically assembling a locked DNA walking arm (DA) and hairpin substrate (HS) into a repetitive array along a well-designed DNA track generated by rolling circle amplification (RCA) and is applied as a 3D DNA nanomachine for rapid and sensitive intracellular microRNA (miRNA) imaging and sensing.

May 26, 2020 - DNA nanomachines are capable of converting tiny triggers into autonomous accelerated cascade hybridization reactions and they have been used as a signal amplification strategy for intracellular imaging.

March 3, 2023 - Au-DNA self-assembled nanomachines can perform intelligent tasks such as sensing biomarkers and delivery of drug molecules through rational customization and programming. By virtue of their efficient signal amplification and flexible scalability, Au-DNA nanomachines have developed into one of the most promising nanodevices.