Studies revealed that, like ibuprofen, oleocanthal inhibits activity of COX-1 and COX-2 enzymes. Because inhibition of COX activity underlies the anti-inflammatory actions of ibuprofen and other non-steroidal anti-inflammatory drugs, or NSAIDs, ...

In EVOO production, olive leaves ... 50 COX-2 = 0.383 mg/mL, Table 3) is improved by 4-fold in COX-1 inhibition and 2-fold in COX-2 inhibition with respect to the IC 50 of the EVOO extract (IC 50 COX-1 = 1.90 mg/mL; IC 50 COX-2 ...

September 21, 2025 - Studies revealed that, like ibuprofen, oleocanthal inhibits activity of COX-1 and COX-2 enzymes. Because inhibition of COX activity underlies the anti-inflammatory actions of ibuprofen and other non-steroidal anti-inflammatory drugs (NSAIDs), ...

June 15, 2012 - In the journal Nature, the Monell team reports that the key to olive oil’s effectiveness is oleocanthoal. Oleocanthol is a pungent compound that has been shown to inhibit two key inflammation triggers: COX-1 and COX-2 enzymes.

January 10, 2013 - Elaiokanthali has significant anti-inflammatory properties acting as a COX-1 and COX-2 inhibitor. It also appears to have protective action against Alzheimer’s disease as well as anticancer properties.

November 14, 2024 - Oleocanthal concentrations in extra ... in rare occasions. Oleocanthal acts as a natural anti-inflammatory agent by inhibiting the activity of cyclooxygenase (COX) enzymes, specifically COX-1 and COX-2....

August 24, 2020 - In vitro evidence has shown some promising results relating to phenolic compounds in Extra Virgin Olive Oil and their ability to inhibit the initiation of metastases of several types of cancer.1 The COX-2 enzyme has been implicated in the ...

Oleocanthal, another secoiridoid found in olive oil, has been described, in previous reports, to have an important inhibitory activity on these cyclooxygenase isoforms, comparable to that of the anti-inflammatory drug ibuprofen [19]. In general, the tested compounds are strong inhibitors of ...

In the search for new cyclooxygenase-2 (COX-2) selective inhibitors, the inhibitory effects of naturally occurring fatty acids and some of their structural derivatives on COX-2-catalyzed prostaglandin biosynthesis were investigated. Among these fatty acids, linoleic acid (LA), α-linolenic ...

Our discovery of COX-inhibitory activity in a component of olive oil offers a possible mechanistic explanation for this link. Avant Labs Rep Sesalean the fat burning oil is now available ... Bet you didn't know that inhibiting COX-2 also leads to an increase in endogenous testosterone.

September 11, 2019 - In-vitro experiments have shown that oleocanthal actually inhibits both COX-1 and COX-2 (Cyclooxygenase 1 and 2) which are enzymes involved in making inflammatory prostaglandins[xiv]. The COX-2 enzyme is upstream of many inflammatory conditions, ...

The results indicated that compound 168 was the most potent of the compounds in inhibiting the protein expression of COX-2. Liu's group110 reported a new phenyl compound 169, which was identified from a mangrove plant derived fungus Botryosphaeria sp. Compound 169 exhibited remarkable COX-2 inhibitory activity (IC50 = 1.12 μmol/L). A few phenylpropanoid derivatives 170–172 were purified from Chinese Olive by He's group111.

October 26, 2017 - A recent study reported similar ... significantly decreased nitric oxide (NO) and ROS production and in addition significant downregulated iNOS, COX-2, reduced MAPK (JNK, p38) phosphorylation and prevented the nuclear NF-κB ...

February 3, 2022 - The book goes into the nitty gritty of chemical reactions in relation to COX-2, plus details of each study. Not to get preachy here, but there are many biblical references to using oil infused with herbs. The word Messiah literally translates to “the one whose head is anointed [with olive oil].” In India, a common practice is to apply sandalwood paste to the forehead.

June 3, 2025 - In 2005, Monell researchers and collaborators announced the discovery that oleocanthal is a non-steroidal, anti-inflammatory agent that inhibits activity of cyclooxygenase (COX) enzymes, a pharmacological action shared by ibuprofen.

July 26, 2024 - Oleic acid (OA) is the main ... in smaller quantities (Figure 1D) [30,31]. SC560 and celecoxib were used as positive control inhibitors for COX-1 and COX-2, respectively....

July 31, 2023 - OL: olive leaves. Figure 5. Acetylcholinesterase (AchE) and cyclooxygenase-2 (COX2) inhibitory activity exerted by OL extracts from Spain, Italy, Greece, and Portugal. Results are expressed as the mean ± standard error of the mean.

December 15, 2019 - COX-2 is an inflammatory enzyme that many drugs target, including Celebrex and NSAIDs like Motrin. Learn about its link to inflammatory diseases, genetics, and whether researchers have discovered any noteworthy natural COX-2 inhibitors.

December 21, 2024 - Here's how this liquid gold fights the fire in your body: ... EVOO contains oleocanthal, a compound that acts like ibuprofen. It blocks the same inflammatory enzymes (COX-1 and COX-2) without the side effects of over-the-counter drugs.

October 1, 2005 - Enzymes in an inflammation pathway are inhibited by oleocanthal, a component of olive oil. ... Gary K. Beauchamp*, Russell S. J. Keast*†, ... Qiang Han||, Chi-Ho Lee*†, Amos B. Smith*||, Paul A. S. Breslin* ... Percentage inhibition of ...