Big Horn Olive Oil
bhooc.com › blogs › articles › olive-oil-fights-inflammation-molecular-level
How Olive Oil Fights Inflammation at the Molecular Level – Big Horn Olive Oil
January 4, 2026 - Lisa Parkinson from Deakin University's School of Exercise and Nutrition Sciences notes, "Oleocanthal not only mimics the mode of ibuprofen inflammatory activity, but inhibits COX 1 and COX 2 enzymes significantly more at equimolar concentrations".
Oleaphen
highphenolic.com › home › blog › oleocanthal in olive oil
Oleocanthal in Olive Oil: Benefits, Mechanism, and How to Find the Highest Concentration
June 17, 2026 - Oleocanthal is a phenolic compound in extra virgin olive oil that inhibits COX-1 and COX-2 enzymes through the same pathway as ibuprofen (Beauchamp et al., Nature, 2005). It does not exist in the olive fruit itself.
Why are COX2 inhibitors bad.
tl;dr: We still have a poor understanding of differential COX-2 expression across various tissues, meaning it has unpredictable effects. Further research is needed. COX-2 specific inhibitors (e.g., roceficoxib, celecoxib) have been under a lot of scrutiny recently because of the associated coronary vasospasm with COX-2 inhibition. You probably learned that COX-1 is constitutive whereas COX-2 is inducible (i.e., COX-2 ramps up especially as an inflammatory response whereas COX-1 is always present low level), but more recent evidence suggests that COX-2 may be constitutive in endothelial cells and the downstream prostacycline effects inhibit platelet aggregation. COX-1/2 inhibitors (e.g., ketorolac, ibuprofen, naproxen) in theory do actually have the same effect, but the key difference is the doses at which they are administered. Celecoxib has a nearly 20:1 preference for COX-2 inhibition over COX-1, whereas ibuprofen is closer to 1:1. Rodent studies have shown chronically giving very high doses of aspirin will also cause coronary vasospasm, in addition to all the bad effects of high level COX-1 inhibition. I was a cardiology grand rounds recently on the topic of COX-2 usage where the presenter talked about COX-2 inhibitor usage. The fundamental point of the talk was that growing evidence suggests we should be identifying cardiac risk factors in patients before perscribing COX-2 inhibitors, because in the abscence of moderate or severe cardiac risk factors use of COX-2 inhibitors doesn't impose significant risk. That being said, the patients who need COX-2 inhibitors are going to be typically older males who will have multiple cardiac risk factors. More on reddit.com
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March 30, 2013COX-2 drugs.
It's just not good for us to take for prolonged periods of time. I will take tylenol every now and then. If you're taking more than 10 a day for a month or two you might want to cut back. But at the same time of you're having pain somewhere it's likely to cause a flare up of the crohn's. I like to think of it as a balancing act. I mean they aren't great for crohn's but what is? They don't want us on pain killers or nsaids and they don't have any other real options so I just try to do the best I can without going insane from pain. Sry if that went back and forth in very high right now lol. I hope it helps a little bit. And I hope you get some relief soon. I'm all to familiar with back pain and it's a bitch. More on reddit.com
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March 9, 2024COX-1 vs COX-2?
Also, COX-1 is constitutively active and relative common in tissues; COX-2 tends to be inducible and active in inflammation/when induced. COX-1 is important for TXA2 synthesis in platelets, COX-2 for PGE2 synthesis in endothelial cells. An example for why it matters: Selective COX-2 inhibitors put the patient at risk due to unopposed COX-1 activity (increased TXA2). That's very brief (and I'm sure there's more if you dig for it). But all I could come up with off the top of my head as I sit on the toilet. More on reddit.com
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October 3, 2018Any mild COX-2 inhibitors?
You mean coxblockers? More on reddit.com
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March 16, 2021How does oleocanthal in olive oil work to reduce inflammation, and how does it compare to ibuprofen?
Extra virgin olive oil contains a natural compound called oleocanthal, which can help reduce inflammation in the body. It works by blocking cyclooxygenase (COX) enzymes, much like ibuprofen does. This means olive oil can offer similar anti-inflammatory benefits, making it a natural and nutritious way to support your body’s response to inflammation.
Adding high-quality olive oil, such as Ultra Premium Extra Virgin Olive Oil, to your meals not only enhances their flavor but also ensures you’re reaping the full health benefits of its active compounds like oleocanthal. Opting for fresh, top-tier olive oil is key to maximizing these advantages.
bhooc.com
bhooc.com › blogs › articles › olive-oil-fights-inflammation-molecular-level
How Olive Oil Fights Inflammation at the Molecular Level – Big ...
How should I store extra virgin olive oil to preserve its anti-inflammatory benefits?
To keep extra virgin olive oil (EVOO) fresh and preserve its beneficial compounds like oleocanthal and oleacein, proper storage is crucial. The main culprits that can degrade EVOO are heat, light, and oxygen. To protect your oil, store it in a cool, dark spot - like a pantry or cupboard - away from heat sources such as stoves or ovens. Ideally, keep the temperature steady between 60–70°F.
Choose containers made from dark-tinted glass, stainless steel, or other opaque materials to shield the oil from light. Make sure the bottle is tightly sealed to minimize air exposure. For everyday use, transfer a small amount into a smaller container that you can finish within a few weeks, and reseal the main bottle promptly after each use. If you plan to store the oil for several months, refrigeration is an option. Just remember to let it return to room temperature before opening to prevent condensation.
By taking these steps, you’ll help maintain the health-boosting polyphenols in Big Horn Olive Oil, ensuring it retains its anti-inflammatory properties with every use.
bhooc.com
bhooc.com › blogs › articles › olive-oil-fights-inflammation-molecular-level
How Olive Oil Fights Inflammation at the Molecular Level – Big ...
Is oleocanthal covered by the EFSA olive oil health claim?
The EU 432/2012 health claim is anchored specifically to hydroxytyrosol and derivatives at a threshold of 5 mg per 20 g of oil. Oleocanthal itself is not the named compound, but in practice it correlates strongly with the hydroxytyrosol family because they share precursors and pathways.
highphenolic.com
highphenolic.com › home › blog › oleocanthal in olive oil
Oleocanthal in Olive Oil: Benefits, Mechanism, and How to Find ...
ScienceDaily
sciencedaily.com › releases › 2005 › 09 › 050906075427.htm
Olive Oil Contains Natural Anti-inflammatory Agent | ScienceDaily
March 27, 2026 - Studies revealed that, like ibuprofen, oleocanthal inhibits activity of COX-1 and COX-2 enzymes. Because inhibition of COX activity underlies the anti-inflammatory actions of ibuprofen and other non-steroidal anti-inflammatory drugs (NSAIDs), ...
ResearchGate
researchgate.net › figure › Relative-inhibition-of-the-COX-1-and-COX-2-enzymes-by-olive-derived-compounds-The_fig2_382601008
Relative inhibition (%) of the COX-1 and COX-2 enzymes by olive-derived... | Download Scientific Diagram
Download scientific diagram | Relative ... compounds. The inhibitory activity of the phenolic compounds OLP, OLC, HT, HTA, OLE, TYR, and HVA, as well as the fatty acids OA, PA, and LA, against COX-1 and COX-2 can be seen....
MDPI
mdpi.com › 1420-3049 › 29 › 15 › 3502
Investigation of the Anti-Inflammatory Properties of Bioactive Compounds from Olea europaea: In Silico Evaluation of Cyclooxygenase Enzyme Inhibition and Pharmacokinetic Profiling
July 26, 2024 - Oleic acid (OA) is the main ... in smaller quantities (Figure 1D) [30,31]. SC560 and celecoxib were used as positive control inhibitors for COX-1 and COX-2, respectively....
Citizens of Soil
citizensofsoil.com › blogs › news › what-is-oleocanthal-and-why-it-matters-for-everyday-wellness
What is Oleocanthal and Why It Matters for Everyday Wellness – Citizens of Soil
June 29, 2026 - Their research, published in Nature, confirmed why: oleocanthal inhibits the same inflammatory enzymes—a rare overlap between a food compound and a pharmaceutical drug. ... Inhibits COX-1 and COX-2 enzymes (these are the same ones as ibuprofen).
ResearchGate
researchgate.net › publication › 7625299_Ibuprofen-like_activity_in_extra-virgin_olive_oil
(PDF) Ibuprofen-like activity in extra-virgin olive oil
October 1, 2005 - Enzymes in an inflammation pathway are inhibited by oleocanthal, a component of olive oil. ... Gary K. Beauchamp*, Russell S. J. Keast*†, ... Qiang Han||, Chi-Ho Lee*†, Amos B. Smith*||, Paul A. S. Breslin* ... Percentage inhibition of ...
Medium
medium.com › @Nutrisphere › oleocanthal-the-natural-ibuprofen-found-in-extra-virgin-olive-oil-979598b24cc7
OLEOCANTHAL: THE NATURAL IBUPROFEN FOUND IN EXTRA VIRGIN OLIVE OIL | by Juan Girones Fraile | Medium
February 25, 2017 - Oleocanthal is not only involved in helping to control inflammation, but it appears to have anti-cancer properties associated with its ability to inhibit COX-2. ... Parkinson, L. & Keast, R. (2014).
Penn Today
penntoday.upenn.edu › news › olive-oil-contains-anti-inflammatory-agent-throaty-sting-provides-clues-benefits-mediterranean-
Olive Oil Contains Anti-inflammatory Agent; Throaty Sting Provides Clues to Benefits of Mediterranean Diet | Penn Today
November 21, 2016 - Studies revealed that, like ibuprofen, oleocanthal inhibits activity of COX-1 and COX-2 enzymes. Because inhibition of COX activity underlies the anti-inflammatory actions of ibuprofen and other non-steroidal anti-inflammatory drugs, or NSAIDs, ...
Olive Wellness Institute
olivewellnessinstitute.org › home › articles › oleocanthal – a phenolic compound with anti-inflammatory action
Oleocanthal – A Phenolic Compound with Anti-inflammatory Action | Olive Wellness Institute
August 24, 2020 - ... Oleocanthal has been shown to act in a similar way to Ibuprofen, through having activity as a cyclo-oxygenase (COX) enzyme inhibitor. It has been suggested that Oleocanthal is a natural non-steroidal anti-inflammatory (NSAID) agent.
Medscape
medscape.com › news › medscape medical news
Olive oil antiinflammatory effects
March 11, 2009 - The investigators then set out ... activity. In fact, newly pressed extra-virgin olive oil contains oleocanthal, both enantiomers of which cause dose-dependent inhibition of both COX-1 and COX-2, but not of lipoxyg...
EXAU Olive Oil
exauoliveoil.com › blogs › olive-oil › is-olive-oil-anti-inflammatory
Is Olive Oil Anti-Inflammatory? What the Science Actually Says – EXAU Olive Oil
March 22, 2026 - It is the same sensation you get from taking ibuprofen. Read more about oleocanthal here. In 2005, a study in the journal Nature found that oleocanthal blocks the same enzymes (COX-1 and COX-2) that ibuprofen does.
Nature
nature.com › nature reviews rheumatology › research highlights › article
Extra-virgin olive oil has similar activity to ibuprofen | Nature Reviews Rheumatology
A recent study has shown that ... dissimilar, they both produce a strong stinging sensation in the throat, and inhibit the same cyclo-oxygenase (COX) enzymes in the prostaglandin biosynthesis pathway....
Olive Wellness Institute
olivewellnessinstitute.org › home › articles › the potential of olive products to reduce inflammation
The Potential of Olive Products to Reduce Inflammation | Olive Wellness Institute
September 11, 2019 - In-vitro experiments have shown that oleocanthal actually inhibits both COX-1 and COX-2 (Cyclooxygenase 1 and 2) which are enzymes involved in making inflammatory prostaglandins[xiv]. The COX-2 enzyme is upstream of many inflammatory conditions, ...
PubMed Central
pmc.ncbi.nlm.nih.gov › articles › PMC6007813
Olive oil polyphenols reduce oxysterols -induced redox imbalance and pro-inflammatory response in intestinal cells - PMC
Most of them have shown a broad ... [23], [24], [25]. The anti-inflammatory activity of olive oil polyphenols seems to be related to their ability to inhibit the pro-inflammatory activity of oxidants-generating enzymes, including cyclooxygenase-2 (COX-2) and inducible nitric ...
O-Liv
o-liv.com › blogs › research › olive-polyphenols-and-inflammation-explained
Olive Polyphenols and Inflammation Explained: How They Work – O-Liv
February 2, 2026 - Our oils are crafted to deliver the phenols and flavor your body actually notices. Shop High-Phenolic Oils · Research has shown that oleocanthal acts as a natural inhibitor of COX-1 and COX-2 enzymes.
Hsionline
hsionline.com › home › reducing inflammation with olive oil
Reducing inflammation with olive oil - Health Sciences Institute - Official Site
June 15, 2012 - In the journal Nature, the Monell team reports that the key to olive oil’s effectiveness is oleocanthoal. Oleocanthol is a pungent compound that has been shown to inhibit two key inflammation triggers: COX-1 and COX-2 enzymes.
Sharecare
sharecare.com › health topics › inflammation › olive oil: an anti-inflammatory superfood
Olive oil: an anti-inflammatory superfood - Sharecare, Inc.
June 6, 2026 - Some research has shown that oleocanthal can reduce production of certain inflammatory enzymes in the body (known as COX-1 and COX-2) in a way similar to the function of the anti-inflammatory drug ibuprofen.
ScienceDirect
sciencedirect.com › science › article › pii › S2772753X26000560
Olive oil compounds: biological and chemical actions for health- an updated review - ScienceDirect
March 10, 2026 - Oleocanthal, a phenolic constituent of olive oil, is believed to suppress COX-1 and COX-2 activity and inhibit lipopolysaccharides, which mediate the upregulation of pro-inflammatory mediators like TNF-α, IL-6 and IL-1β.
