discover the anti-inflammatory benefits of olive oil, which chronic diseases can the anti-inflammatory properties of olive oil prevent More on clinicadvisor.com

tl;dr: We still have a poor understanding of differential COX-2 expression across various tissues, meaning it has unpredictable effects. Further research is needed. COX-2 specific inhibitors (e.g., roceficoxib, celecoxib) have been under a lot of scrutiny recently because of the associated coronary vasospasm with COX-2 inhibition. You probably learned that COX-1 is constitutive whereas COX-2 is inducible (i.e., COX-2 ramps up especially as an inflammatory response whereas COX-1 is always present low level), but more recent evidence suggests that COX-2 may be constitutive in endothelial cells and the downstream prostacycline effects inhibit platelet aggregation. COX-1/2 inhibitors (e.g., ketorolac, ibuprofen, naproxen) in theory do actually have the same effect, but the key difference is the doses at which they are administered. Celecoxib has a nearly 20:1 preference for COX-2 inhibition over COX-1, whereas ibuprofen is closer to 1:1. Rodent studies have shown chronically giving very high doses of aspirin will also cause coronary vasospasm, in addition to all the bad effects of high level COX-1 inhibition. I was a cardiology grand rounds recently on the topic of COX-2 usage where the presenter talked about COX-2 inhibitor usage. The fundamental point of the talk was that growing evidence suggests we should be identifying cardiac risk factors in patients before perscribing COX-2 inhibitors, because in the abscence of moderate or severe cardiac risk factors use of COX-2 inhibitors doesn't impose significant risk. That being said, the patients who need COX-2 inhibitors are going to be typically older males who will have multiple cardiac risk factors. More on reddit.com

It's just not good for us to take for prolonged periods of time. I will take tylenol every now and then. If you're taking more than 10 a day for a month or two you might want to cut back. But at the same time of you're having pain somewhere it's likely to cause a flare up of the crohn's. I like to think of it as a balancing act. I mean they aren't great for crohn's but what is? They don't want us on pain killers or nsaids and they don't have any other real options so I just try to do the best I can without going insane from pain. Sry if that went back and forth in very high right now lol. I hope it helps a little bit. And I hope you get some relief soon. I'm all to familiar with back pain and it's a bitch. More on reddit.com

Also, COX-1 is constitutively active and relative common in tissues; COX-2 tends to be inducible and active in inflammation/when induced. COX-1 is important for TXA2 synthesis in platelets, COX-2 for PGE2 synthesis in endothelial cells. An example for why it matters: Selective COX-2 inhibitors put the patient at risk due to unopposed COX-1 activity (increased TXA2). That's very brief (and I'm sure there's more if you dig for it). But all I could come up with off the top of my head as I sit on the toilet. More on reddit.com