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Big Horn Olive Oil
bhooc.com › blogs › articles › olive-oil-fights-inflammation-molecular-level
How Olive Oil Fights Inflammation at the Molecular Level – Big Horn Olive Oil
1 month ago - Lisa Parkinson from Deakin University's School of Exercise and Nutrition Sciences notes, "Oleocanthal not only mimics the mode of ibuprofen inflammatory activity, but inhibits COX 1 and COX 2 enzymes significantly more at equimolar concentrations".
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PubMed Central
pmc.ncbi.nlm.nih.gov › articles › PMC6007813
Olive oil polyphenols reduce oxysterols -induced redox imbalance and pro-inflammatory response in intestinal cells - PMC
Most of them have shown a broad ... [23], [24], [25]. The anti-inflammatory activity of olive oil polyphenols seems to be related to their ability to inhibit the pro-inflammatory activity of oxidants-generating enzymes, including cyclooxygenase-2 (COX-2) and inducible nitric ...
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ScienceDaily
sciencedaily.com › releases › 2005 › 09 › 050906075427.htm
Olive Oil Contains Natural Anti-inflammatory Agent | ScienceDaily
September 21, 2025 - Studies revealed that, like ibuprofen, oleocanthal inhibits activity of COX-1 and COX-2 enzymes. Because inhibition of COX activity underlies the anti-inflammatory actions of ibuprofen and other non-steroidal anti-inflammatory drugs (NSAIDs), ...
People also ask

How does oleocanthal in olive oil work to reduce inflammation, and how does it compare to ibuprofen?

Extra virgin olive oil contains a natural compound called oleocanthal, which can help reduce inflammation in the body. It works by blocking cyclooxygenase (COX) enzymes, much like ibuprofen does. This means olive oil can offer similar anti-inflammatory benefits, making it a natural and nutritious way to support your body’s response to inflammation.

Adding high-quality olive oil, such as Ultra Premium Extra Virgin Olive Oil, to your meals not only enhances their flavor but also ensures you’re reaping the full health benefits of its active compounds like oleocanthal. Opting for fresh, top-tier olive oil is key to maximizing these advantages.

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bhooc.com
bhooc.com › blogs › articles › olive-oil-fights-inflammation-molecular-level
How Olive Oil Fights Inflammation at the Molecular Level – Big ...
How should I store extra virgin olive oil to preserve its anti-inflammatory benefits?

To keep extra virgin olive oil (EVOO) fresh and preserve its beneficial compounds like oleocanthal and oleacein, proper storage is crucial. The main culprits that can degrade EVOO are heat, light, and oxygen. To protect your oil, store it in a cool, dark spot - like a pantry or cupboard - away from heat sources such as stoves or ovens. Ideally, keep the temperature steady between 60–70°F.

Choose containers made from dark-tinted glass, stainless steel, or other opaque materials to shield the oil from light. Make sure the bottle is tightly sealed to minimize air exposure. For everyday use, transfer a small amount into a smaller container that you can finish within a few weeks, and reseal the main bottle promptly after each use. If you plan to store the oil for several months, refrigeration is an option. Just remember to let it return to room temperature before opening to prevent condensation.

By taking these steps, you’ll help maintain the health-boosting polyphenols in Big Horn Olive Oil, ensuring it retains its anti-inflammatory properties with every use.

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bhooc.com
bhooc.com › blogs › articles › olive-oil-fights-inflammation-molecular-level
How Olive Oil Fights Inflammation at the Molecular Level – Big ...
How much extra virgin olive oil should I use daily for the best health benefits?

For the best health perks, aim to include 1 to 2 tablespoons of extra virgin olive oil in your daily diet. It’s simple to work this into your meals - drizzle it over a fresh salad, whisk it into a dressing, or add a touch to finish off a cooked dish for extra flavor.

Packed with healthy fats and antioxidants, extra virgin olive oil is known for its anti-inflammatory properties and overall wellness benefits. To get the most out of it, opt for a high-quality, fresh olive oil to ensure both maximum nutrition and taste.

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bhooc.com
bhooc.com › blogs › articles › olive-oil-fights-inflammation-molecular-level
How Olive Oil Fights Inflammation at the Molecular Level – Big ...
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ResearchGate
researchgate.net › figure › Inhibitory-effects-of-EVOO-and-EVOO-OLE-8-on-COX-1-and-COX-2_tbl2_368721010
Inhibitory effects of EVOO and EVOO/OLE 8% on COX-1 and COX-2. | Download Scientific Diagram
In EVOO production, olive leaves ... 50 COX-2 = 0.383 mg/mL, Table 3) is improved by 4-fold in COX-1 inhibition and 2-fold in COX-2 inhibition with respect to the IC 50 of the EVOO extract (IC 50 COX-1 = 1.90 mg/mL; IC 50 COX-2 ...
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Penn Today
penntoday.upenn.edu › news › olive-oil-contains-anti-inflammatory-agent-throaty-sting-provides-clues-benefits-mediterranean-
Olive Oil Contains Anti-inflammatory Agent; Throaty Sting Provides Clues to Benefits of Mediterranean Diet | Penn Today
Studies revealed that, like ibuprofen, oleocanthal inhibits activity of COX-1 and COX-2 enzymes. Because inhibition of COX activity underlies the anti-inflammatory actions of ibuprofen and other non-steroidal anti-inflammatory drugs, or NSAIDs, ...
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Hsionline
hsionline.com › home › reducing inflammation with olive oil
Reducing inflammation with olive oil - Health Sciences Institute - Official Site
June 15, 2012 - In the journal Nature, the Monell team reports that the key to olive oil’s effectiveness is oleocanthoal. Oleocanthol is a pungent compound that has been shown to inhibit two key inflammation triggers: COX-1 and COX-2 enzymes.
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Sabinsa
sabinsa.com › newsletters-december-2004-january-2005 › 589-a-focus-on-natural-cox-2-inhibitors
A Focus on Natural COX-2 Inhibitors - Sabinsa Corporation | Health Nutrition Industry
Green tea polyphenols are also reported to inhibit COX-2 and TNF-alpha. Similarly, ginger extract (6-gingerol and gingerdiones) is a dual inhibitor of inflammation, acting by inhibiting the formation of both prostaglandins and leukotrienes.
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Olive Wellness Institute
olivewellnessinstitute.org › home › articles › oleocanthal – a phenolic compound with anti-inflammatory action
Oleocanthal – A Phenolic Compound with Anti-inflammatory Action | Olive Wellness Institute
August 24, 2020 - In vitro evidence has shown some promising results relating to phenolic compounds in Extra Virgin Olive Oil and their ability to inhibit the initiation of metastases of several types of cancer.1 The COX-2 enzyme has been implicated in the ...
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Olive Wellness Institute
olivewellnessinstitute.org › home › articles › the potential of olive products to reduce inflammation
The Potential of Olive Products to Reduce Inflammation | Olive Wellness Institute
September 11, 2019 - In-vitro experiments have shown that oleocanthal actually inhibits both COX-1 and COX-2 (Cyclooxygenase 1 and 2) which are enzymes involved in making inflammatory prostaglandins[xiv]. The COX-2 enzyme is upstream of many inflammatory conditions, ...
Find elsewhere
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ResearchGate
researchgate.net › publication › 7625299_Ibuprofen-like_activity_in_extra-virgin_olive_oil
(PDF) Ibuprofen-like activity in extra-virgin olive oil
October 1, 2005 - Enzymes in an inflammation pathway are inhibited by oleocanthal, a component of olive oil. ... Gary K. Beauchamp*, Russell S. J. Keast*†, ... Qiang Han||, Chi-Ho Lee*†, Amos B. Smith*||, Paul A. S. Breslin* ... Percentage inhibition of ...
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ACS Publications
pubs.acs.org › doi › abs › 10.1021 › np000620d
COX-2 Inhibitory Effects of Naturally Occurring and Modified Fatty Acids | Journal of Natural Products
In the search for new cyclooxygenase-2 (COX-2) selective inhibitors, the inhibitory effects of naturally occurring fatty acids and some of their structural derivatives on COX-2-catalyzed prostaglandin biosynthesis were investigated. Among these fatty acids, linoleic acid (LA), α-linolenic ...
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PubMed
pubmed.ncbi.nlm.nih.gov › 32942970
Natural COX-2 Inhibitors as Promising Anti-inflammatory Agents: An Update - PubMed
The review mainly concentrated on recently identified natural products and derivatives as COX-2 inhibitors, the characteristics of their structural core scaffolds, their anti-inflammatory effects, molecular mechanisms for enzymatic inhibition, and related structure-activity relationships.
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Healthy Living
healthylivingmarket.com › home › blog › cox-2 inhibitors: omega-3s, transdermal herbalism & aromatherapy
COX-2 Inhibitors: Omega-3s, Transdermal Herbalism & Aromatherapy - Healthy Living
February 3, 2022 - The book goes into the nitty gritty of chemical reactions in relation to COX-2, plus details of each study. Not to get preachy here, but there are many biblical references to using oil infused with herbs. The word Messiah literally translates to “the one whose head is anointed [with olive oil].” In India, a common practice is to apply sandalwood paste to the forehead.
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BioArmonia
bioarmonia.gr › articles › item › 1334-powerful-anti-inflammatory-benefits-olive-oil
Powerful Anti-Inflammatory Benefits of Olive Oil
November 12, 2020 - Oleocanthal has been shown to stop the inflammatory cascade by inhibiting both cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2) inflammatory enzymes in a dose-dependent manner.
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SelfHacked
selfhacked.com › home › posts › cox-2, inflammation, potential natural inhibitors & genes
COX-2, Inflammation, Potential Natural Inhibitors & Genes - SelfHacked
December 15, 2019 - COX-2 is an inflammatory enzyme that many drugs target, including Celebrex and NSAIDs like Motrin. Learn about its link to inflammatory diseases, genetics, and whether researchers have discovered any noteworthy natural COX-2 inhibitors.
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ScienceDaily
sciencedaily.com › releases › 2011 › 01 › 110118180514.htm
NSAID receptor responsible for olive oil's 'cough' and more | ScienceDaily
December 19, 2025 - In 2005, Monell researchers and collaborators announced the discovery that oleocanthal is a non-steroidal, anti-inflammatory agent that inhibits activity of cyclooxygenase (COX) enzymes, a pharmacological action shared by ibuprofen.
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MDPI
mdpi.com › 2076-3921 › 12 › 8 › 1538
Exploring the Antioxidant, Neuroprotective, and Anti-Inflammatory Potential of Olive Leaf Extracts from Spain, Portugal, Greece, and Italy
July 31, 2023 - OL: olive leaves. Figure 5. Acetylcholinesterase (AchE) and cyclooxygenase-2 (COX2) inhibitory activity exerted by OL extracts from Spain, Italy, Greece, and Portugal. Results are expressed as the mean ± standard error of the mean.
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Bodybuilding.com
forum.bodybuilding.com › showthread.php
Olive Oil may be a VERY bad choice !?!?!?!?! (COX inhibitor) - Bodybuilding.com Forums
We already know that ibuprofen, ... didn't already know this- welcome!) Well, unfortunately, olive oil contains a newly discovered compound called oleocanthal that is also a COX inhibitor very similar to ibuprofen....
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Nature
nature.com › nature reviews rheumatology › research highlights › article
Extra-virgin olive oil has similar activity to ibuprofen | Nature Reviews Rheumatology
A recent study has shown that ... dissimilar, they both produce a strong stinging sensation in the throat, and inhibit the same cyclo-oxygenase (COX) enzymes in the prostaglandin biosynthesis pathway....