Paw edema is defined as a localized inflammatory response characterized by swelling in the paw, commonly induced by the injection of lipopolysaccharide (LPS), which triggers the release of pro-inflammatory cytokines such as TNF-α and IL-1.

December 22, 2025 - Typical signs of inflammation include edema, hyperalgesia, and erythema, which develop immediately following the treatment of carrageenan. Generally, animals are injected with a certain concentration (usually 1%) of the irritant substance carrageenan in one hind footpad, usually, half an hour ...

Single-dose administration of naproxen (15 mg/kg) or indomethacin (10 mg/kg) exerts decrease in rat paw oedema volume at no later than 5 hours after oedema induction by carrageenan. Evaluating anti-inflammatory activity by the areas under the curve «increase in paw volume - time» proves that a singl …

Neutrophils readily migrate to ... response is usually quantified by increase in paw size (edema) which is maximal around 5 h postcarrageenan injection (see Fig....

On study day 0, animals are time dosed at one minute intervals and then injected with carrageenan (1.2% in saline) in the right hind paw at corresponding 1-minute intervals to induce edema.

Carrageenan-induced paw edema in the rat and mouse

Neutrophils readily migrate to ... response is usually quantified by increase in paw size (edema) which is maximal around 5 h postcarrageenan injection (see Fig....

May 15, 2001 - Paw swelling, or footpad edema, is a convenient method for assessing inflammatory responses to antigenic challenges and irritants. The protocol described in this unit uses carrageenan as the irritant to induce paw edema.

February 13, 2020 - Carrageenan injection induced paw edema which was peaked at 6 h and gradually decreased nearly to the initial baseline value after 72 h. LIUS showed a significant reduction of paw edema formation at 2 and 6 h at all intensities tested. The highest reduction was observed at the intensity of 50 mW/cm2.

May 1, 2001 - Paw swelling, or footpad edema, is a convenient method for assessing inflammatory responses to antigenic challenges and irritants. The protocol described in this unit uses carrageenan as the irritant to induce paw edema.

July 15, 2025 - Rats in the Carr group, who received a 1% carrageenan injection, had redness, hotness, and swelling in their left hind paw, as seen in Figure 5. The paw edema volume also significantly increased after 1, 2, 3, and 4 h postinjection.

The results showed that intraplantar ... E2 (PGE2) and also iNOS and COX-2 protein expression in inflamed paw. However, systemic administration of EA (1–30 mg/kg, intraperitoneal [i.p.]) could reduce edema in a dose-dependent fashion in inflamed rat paws with ED50 value 8.41 ...

Carrageenan-induced paw edema is defined as an acute local inflammatory response resulting from carrageenan injection, commonly used to screen for anti-inflammatory activity and to study nonsteroidal anti-inflammatory drugs.

1. Injection of carrageenan into the mouse paw produced a biphasic edema. During the first phase, which developed up to 24 h, edema was of low intensity and unrelated to the dose of carrageenan given.

The Carrageenan-Induced Paw Edema model provides rapid assessment of a compound’s ability to provide anti-inflammatory and analgesic activity.

Acute inflammatory response is characterized by an increase in vascular permeability and cellular infiltration leading to oedema formation, as a result of extravasation of fluid and proteins and accumulation of leukocytes at the inflammatory site. Carrageenan-induced rat paw oedema is a widely used test to determine the anti-inflammatory activity, and it has been fully characterized in the past (Di Rosa et al., 1971a, 1971b; 1972, Garcia Leme et al., 1973).

March 1, 2024 - The current work aimed to examine the potential anti-inflammatory effects of EPSSM through the utilization of the carrageenan-induced hind paw edema model. The findings of our study provide compelling evidence of the anti-inflammatory and antioxidant efficacy of EPSSM.

The maximum volume of oedema was observed in the control group at 3 h after the injection of carrageenan, which is in accordance with the literature data on the development of carrageenan paw edema in rats [10, 11]. Naproxen at a dose of 15 mg/kg showed anti-inflammatory activity at 1, 2, 3, 4 and 5 hours after administration of carrageenan with suppression of oedema development by 59, 81, 73, 60 and 39% (p = 0.03; 0.001; 0.001; 0.001 and 0.01), respectively.

March 24, 2004 - Carrageenan-induced inflammation in the rat paw represents a classical model of edema formation and hyperalgesia, which has been extensively used in the development of nonsteroidal anti-inflammatory drugs and selective COX1 -2 inhibitors.

September 11, 2023 - Recently, fucoidan derived from different algal sources has been a subject of intensive research [22,23,24,25]. We registered a well-defined anti-inflammatory activity of fucoidan from E. crinita in carrageenan-induced rat paw edema.