January 8, 2016 - Corona phase molecular recognition (CoPhMoRe) uses a heteropolymer adsorbed onto and templated by a nanoparticle surface to recognize a specific target analyte. This method has not yet been extended to macromolecular analytes, including proteins.

January 8, 2016 - Corona phase molecular recognition (CoPhMoRe) uses a heteropolymer adsorbed onto and templated by a nanoparticle surface to recognize a specific target analyte. This method has not yet been extended to macromolecular analytes, including proteins.

The key to biorecognition consists of a unique three-dimensional structure formed by a folded and constrained bioheteropolymer that creates a binding pocket, or an interface, able to recognize a specific molecule. Here, we show that synthetic heteropolymers, once constrained onto a single-walled carbon nanotube by chemical adsorption, also form a new corona phase that exhibits highly selective recognition for specific molecules.

November 24, 2013 - The key to biorecognition consists of a unique three-dimensional structure formed by a folded and constrained bioheteropolymer that creates a binding pocket, or an interface, able to recognize a specific molecule. Here, we show that synthetic heteropolymers, once constrained onto a single-walled carbon nanotube by chemical adsorption, also form a new corona phase that exhibits highly selective recognition for specific molecules.

We hypothesize that a combination of the SWCNT corona phase formed by the specific phospholipid-PEG along with the unique three-dimensional conformation of the fibrinogen protein, a high aspect ratio elongated molecule, is responsible for the molecular recognition.

November 16, 2014 - demonstration of dynamic, high-resolution detection of intracellu- lar riboflavin concentration gradients. Conclusions · We have reported a new and generic molecular recognition concept, called corona phase molecular recognition, arising from a folded · and constrained heteropolymer pinned at an SWNT interface via ·

August 10, 2025 - The key to biorecognition consists of a unique three-dimensional structure formed by a folded and constrained bioheteropolymer that creates a binding pocket, or an interface, able to recognize a specific molecule. Here, we show that synthetic heteropolymers, once constrained onto a single-walled carbon nanotube by chemical adsorption, also form a new corona phase that exhibits highly selective recognition for specific molecules.

October 14, 2020 - In this work, we generate and screen a library of 24 amphiphilic polymers, preselected for molecular recognition and based on functional monomers including methacrylic acid, acrylic acid, and styrene, iterating upon a poly(methacrylic acid-co-styrene) motif. When complexed to a single-walled carbon nanotube, some of the resulting corona phases demonstrate binding specificity remarkably similar to that of phosphodiesterase type 5 (PDE5), an enzyme that catalyzes the hydrolysis of secondary messenger.

August 28, 2015 - Corona phase molecular recognition (CoPhMoRe) is a phenomenon whereby a polymer or surfactant corona phase wrapped around a nanoparticle selectively recognizes a particular molecule.

Europe PMC is an archive of life sciences journal literature.

The key to biorecognition consists of a unique three-dimensional structure formed by a folded and constrained bioheteropolymer that creates a binding pocket, or an interface, able to recognize a specific molecule. Here, we show that synthetic heteropolymers, once constrained onto a single-walled carbon nanotube by chemical adsorption, also form a new corona phase that exhibits highly selective recognition for specific molecules.

Of 14 protein analytes and 20 distinct SWCNT corona phases screened, a particular corona phase molecular recognition (CoPhMoRe) scheme using SWCNT suspended in a phospholipid-PEG construct was discovered to be capable of recognizing fibrinogen, a blood plasma macromolecule protein.

Understanding the fundamental molecular recognition mechanism of cytokines with synthetic substrates is key to developing new biomedical technologies such as assays, sensors, and therapeutics that overcome the above limitations. Herein, we use the corona phase molecular recognition (CoPhMoRe) approach to engineer new carbon nanotube constructs and study their binding to the inflammatory cytokines: IL-6, interleukin-11 (IL-11), ciliary neurotrophic factor (CNTF), and leukemia inhibitory factor (LIF).

Corona Phase Molecular Recognition (CoPhMoRe) utilizing a heteropolymer adsorbed onto and templated by a nanoparticle surface to recognize a specific target analyte can be used for macromolecular analytes, including proteins. A variant of a CoPhMoRe screening procedure of single walled carbon ...

Corona phase molecular recognition (CoPhMoRe) uses a heteropolymer adsorbed onto and templated by a nanoparticle surface to recognize a specific target analyte. This method has not yet been extended to macromolecular analytes, including proteins. Herein we develop a variant of a CoPhMoRe screening ...

corona phase that exhibits highly selective recognition for specific molecules.

The key to biorecognition consists of a unique three-dimensional structure formed by a folded and constrained bioheteropolymer that creates a binding pocket, or an interface, able to recognize a specific molecule. Here, we show that synthetic heteropolymers, once constrained onto a single-walled carbon nanotube by chemical adsorption, also form a new corona phase that exhibits highly selective recognition for specific molecules.

March 21, 2024 - Zhang, J., Landry, M. P., Barone, P. W., Kim, J. H., Lin, S., Ulissi, Z. W., Lin, D., Mu, B., Boghossian, A. A., Hilmer, A. J., Rwei, A., Hinckley, A. C., Kruss, S., Shandell, M. A., Nair, N., Blake, S., Şen, F., Şen, S., Croy, R. G., ... Strano, M. S. (2013). Molecular recognition using corona phase complexes made of synthetic polymers adsorbed on carbon nanotubes.