April 20, 2023 - Treatment for plague begins as soon as the health care provider suspects the disease. Treatment is typically done in the hospital.

July 9, 2024 - Plague can be cured with antibiotics, but treatment must be given promptly.

June 17, 2024 - An in vitro comparison [38] and a murine model [39] demonstrated that gentamicin (5 mg/kg intravenously or intramuscularly once daily) is comparable to or superior than streptomycin. Gentamicin has been used successfully in the treatment of human plague, [19] is inexpensive, and can be dosed once daily.

April 9, 2026 - Healthcare providers treat plague with antibiotics. They’ll give you medication either through a vein (IV) or in a pill. Depending on your symptoms and risk, you may start antibiotics even before test results come back.

November 20, 2023 - The disease is most common in parts of Africa, Asia and South America, but it also occurs in some areas of the western United States. Symptoms can include an abrupt onset of chills, fever, and enlarged, painful lymph nodes (buboes). Most cases of plague resolve with effective treatment, though treatment must be started immediately to avoid life-threatening complications.

If left untreated, these buboes ... antibiotics can significantly increase survival rates [19,21,22]. Aminoglycosides, such as streptomycin and gentamicin, tetracyclines, and the fluoroquinolone ciprofloxacin are some effective antibiotics for bubonic plague treatment ...

September 29, 2026 - Untreated pneumonic plague can be rapidly fatal, so early diagnosis and treatment are essential for survival and reduction of complications. Antibiotics and supportive therapy are effective against plague if patients are diagnosed in time.

Plague can be treated successfully with intravenous antibiotics if appropriate therapy is started early. The duration of treatment is generally 10-14 days.

Begin appropriate IV therapy as soon as plague is suspected. Gentamicin and fluoroquinolones are typically first‐line treatments in the United States.

Gentamicin and tetracyclines have been used with success (11, 23, 45), while trimethoprim-sulfamethoxazole has also been employed, with both success (32) and disappointing results (6). For the treatment of pneumonic plague, streptomycin, ...

April 9, 2026 - Bubonic plague, a potentially fatal infection spread mainly by fleas, still exists. Antibiotics can treat this form of the plague.

August 8, 2022 - Two classes of antibiotics are recommended for the initial treatment for Y. pestis infection, at least one of which is considered first-line. See the CDC’s recommendations for the antimicrobial treatment and prophylaxis of plague resulting from either naturally occurring transmission or a bioterrorism-related event (Tables 1-3, 5, 7, 8).

For instance, experiments with the hollow-fiber model suggest that gentamicin and ciprofloxacin should be similarly effective in the treatment of Y. pestis infections in humans [73]. However, although ciprofloxacin protects mice from bubonic plague as well as gentamicin does, only ciprofloxacin eradicates Y.

January 7, 2003 - Plague is an infectious disease caused by the bacterium Yersinia pestis. Plague most commonly occurs in rodents and their fleas, but it also can occur in humans when they are bitten by fleas infected with the plague bacteria. There are three types of plague: bubonic, pneumonic and septicemic.

Treatment duration is generally 10-14 days or at least 2 days after fever resolves. Pneumonic or septicemic plague: IV (or PO if available) ciprofloxacin, levofloxacin, streptomycin, or gentamicin for both children and adults.

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Presumptive therapy (post-exposure prophylaxis) consists of a 7-day course of oral doxycycline and ciprofloxacin as first line treatment in adults. Treatment of an established case is usually for 10-14 days. In a community experiencing a pneumonic plague epidemic, individuals with a temperature ...

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Fluoroquinolones, tetracyclines and streptomycin are the antibiotics of choice for treating plague. These antibiotics are completely effective if administered early. Early administration of tetracyclines, sulfonamides or fluoroquinolones is generally a highly effective preventive treatment ...

February 5, 2026 - All forms of plague are associated with a high mortality rate (approaching 100% for pneumonic and septicaemic forms and around 60% for bubonic plague) and, in addition, pneumonic plague can be associated with human-to-human transmission. Antibiotic treatment can be effective but early diagnosis and treatment are vital.