To facilitate spatially restricted and remotely controlled delivery of neuromodulators to neural targets, we sought to gate the release of small molecules using non-invasive stimuli.

3 weeks ago - State-of-the-Art Performance: The approach surpassed previous neural delivery systems (e.g., NAS) across multiple backbones (SRCNN, VDSR, EDSR) and scaling factors ($\times2, \times3, \times4$). By embracing overfitting through Content-aware Feature Modulation, this work demonstrates a highly efficient path for neural video delivery.

In this paper, we survey state-of-the-art content delivery systems that employ neural enhancement as a key component in achieving both fast response time and high visual quality. We first present the deployment challenges of neural enhancement models. We then cover systems targeting diverse use-cases and analyze their design decisions in overcoming technical challenges.

Consequently, a large number of models are streamed in order to deliver a video. In this paper, we first carefully study the relation between models of different chunks, then we tactfully design a joint training framework along with the Content-aware Feature Modulation (CaFM) layer to compress these models for neural video delivery.

Recently, Deep Neural Networks (DNNs) are utilized to reduce the bandwidth and improve the quality of Internet video delivery. Existing methods train corresponding content-aware super-resolution (SR) model for each video chunk on the server, and ...

September 19, 2024 - In addition to the stimulation and modulation of neurons with Piezo1 channels, the drug loading and delivery capability of our dart can also be used for the stimulation and modulation of neurons without Piezo1 channel. As an example, Supplementary Fig. S18 shows the stimulation of neurons without Piezo1 channel (F11 dorsal root ganglion cells and SH-Sy5y neuroblastoma cells) by loading the dart with β-nerve growth factor (β-NGF). After precision shooting of the dart to the target cell, the loaded β-NGF was released to the target cell, and the treated cell shows a higher growth rate than the neighboring cells without dart treatment.

June 5, 2025 - This technique of combining neuro-contextual insights and agentic-driven action has transformed contextual advertising from an advanced targeting approach into a completely integrated media solution for privacy-first advertising — one that exceeds what is possible through traditional behavioral targeting. Embeddings are the foundation of neuro-contextual understanding. They are a neural network layer that transforms content and campaign prompts into numerical vectors that represent meaning and intent.

Here, we developed a remotely controlled chemomagnetic modulation – a technique to pharmacologically modulate targeted neural population with temporal and spatial precision in freely moving mice. The heat dissipated by magnetic nanoparticles in the presence of alternating magnetic fields triggered small molecule release from thermally sensitive lipid vesicles with 20 s latency. Coupled with chemogenetic activation of engineered receptors, this technique permitted control of the activity of specific neurons. Delivery of chemomagnetic particles to the ventral tegmental area allowed remote temporally precise modulation of motivated behavior in mice.

The advent of nanotechnology represents a new advancement in neural modulation techniques, offering high precision and the ability to target specific cell types. Smart nanomaterials enable the conversion of remote signals (such as light, magnetic, or ultrasound) into local stimuli (eg, electric fields or heat) for neurons. Surface treatment technologies of nanomaterials have enhanced biocompatibility, making targeted delivery to specific cell types possible and paving the way for precise neural modulation.

November 20, 2024 - The advent of nanotechnology represents a new advancement in neural modulation techniques, offering high precision and the ability to target specific cell types. Smart nanomaterials enable the conversion of remote signals (such as light, magnetic, or ultrasound) into local stimuli (eg, electric fields or heat) for neurons. Surface treatment technologies of nanomaterials have enhanced biocompatibility, making targeted delivery to specific cell types possible and paving the way for precise neural modulation.

In this paper, we survey state-of-the-art content delivery systems that employ neural enhancement as a key component in achieving both fast response time and high visual quality. We first present the deployment challenges of neural enhancement models. We then cover systems targeting diverse ...

August 5, 2026 - Neuromodulation is "the alteration of nerve activity through targeted delivery of a stimulus, such as electrical stimulation or chemical agents, to specific neurological sites in the body". It is carried out to normalize – or modulate – nervous tissue function.

Networks (DNNs) to video delivery system [14, 30]. The · core idea of these works is to stream both the low resolu- tion video and content-aware models from servers to clients. The clients run the inference of models to super-resolve the · LR videos. In this manner, better user Quality of Experi- ence (QoE) can be obtained under limited Internet band- ... Feature Modulation (CaFM) layer.

Genetics-based neuromodulation schemes are capable of selectively manipulating the activity of defined cell populations with high temporal-spatial resolution, providing unprecedented opportunities for probing cellular biological mechanisms, resolving neuronal projection pathways, mapping neural profiles, and precisely treating neurological and psychiatric disorders. Multimodal implementation schemes, which involve the use of exogenous stimuli such as light, heat, mechanical force, chemicals, electricity, and magnetic stimulation in combination with specific genetically engineered effectors, greatly expand their application space and scenarios. In particular, advanced wireless stimulation schemes have enabled low-invasive targeted neuromodulation through local delivery of navigable micro- and nanosized stimulators.

April 16, 2024 - This may lead to more accurate machine-learning models if data for a particular patient are limited. A model can be trained first on data from other patients and then be fine-tuned on data of the target patient by means of transfer learning. AI has improved tremendously in its decoding accuracy of neural signals.

In 2017 devices for neuromodulation are either neural stimulators, neural receivers/stimulators, a combination of neural receivers, computers, and machine actuators or micropumps (IDDS) that “target” deliver analgesic and nonanalgesic medications.

The International Neuromodulation ... the delivery of electromagnetic stimulation or chemical agents to targeted sites of the body. Founded in 1989 and based in San Francisco, CA, the INS educates and promotes the field through meetings, its MEDLINE-indexed, peer-reviewed journal Neuromodulation: ...

June 16, 2026 - Transient effects create acute momentary adjustments in neural activity. Lastly, as the name suggests, stimulus-driven effects react to sensory input, external stressors, and reward stimuli, which involve dopamine, norepinephrine, and serotonin. The term Neuromodulation is also known in medicine as a targeted artificial modification of neuronal activity through the delivery ...

March 3, 2020 - The International Neuromodulation ... as “the alteration of nerve activity through targeted delivery of a stimulus, such as electrical stimulation or chemical agents, to specific neurological sites in the body.” ...

Platforms for these in vitro neural networks require precise and selective neural connections at the target location, with minimal external influences, and measurement of neural activity to determine how neurons communicate. Here, we report a neuron-loaded microrobot for selective connection of neural networks via precise delivery to a gap between two neural clusters by an external magnetic field.