Lowering blood cholesterol levels protects atherosclerosis. It was shown that functional foods such as vegetables, fruit fibers, fish oil, etc. have hypocholesterolemic effects and inhibit and suppress fat absorption and in vivo cholesterol synthesis (Carlos & Ferrari, 2017).

January 28, 2026 - Hypocholesterolemia may lead to mild liver dysfunction or fatty liver disease. You may also have problems with your eyes, brain, liver, muscles or bones. This comes from not having enough vitamin A, D, E or K in your body.

March 10, 2026 - In the elderly, low cholesterol may confer a health risk that may not be offset by the beneficial effects of cholesterol lowering. Similarly, for elderly patients admitted to hospital, low cholesterol may predict short-term mortality. The prevalence of hypocholesterolemia in the elderly ranges ...

The hypocholesterolemic effects of plant sterols, fiber, Monascus products and soy protein preparations have been consistently demonstrated in clinical trails whereas the efficacy of some probiotic bacteria and phytoestrogens-containing supplements ...

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August 23, 2022 - There has been some evidence that hypocholesterolemia can cause depression, suicidal ideation, and other effects on your mood or behavior.

Diets supplemented with oat products significantly lower serum cholesterol concentrations of humans (deGroot et al, 1963; Kirby et al., 1981; Judd and Truswell, 1981; Anderson et al., 1984b) and rats (Chen and Anderson, 1979). Since 1977 we have evaluated the hypocholesterolemic effects of oat bran; here we review these results in order to discuss the potential mechanisms involved for the cholesterol-lowering properties of soluble fibers.

Cholesterol biosynthesis enzyme HMG-CoA reductase is the target of most of the hypocholesterolemic drugs since it is the rate-limiting enzyme. However, myositis, gastrointestinal symptoms, pharyngitis, and pain are commonly associated side effects with these types of drugs.

Hypercholesterolemia is a significant risk factor for coronary heart disease, and the hypocholesterolemic effects of psyllium are well established. This placebo-controlled, parallel study compared psyllium with methylcellulose, calcium polycarbophil, and placebo as dietary adjuncts in treating mild to moderate hypercholesterolemia.

Within 1 week SCH 48461 (1 mg/kg ... values. SCH 48461 exerted its hypocholesterolemic effect through the inhibition of cholesterol absorption....

In fact, individuals with PCSK9 deficiency may experience hepatoprotective effects that reduce risk of nonalcoholic fatty liver disease [Citation75,Citation76]. Of note, rare variants in other genes, such as CIDEB which encodes a structural protein on lipid droplets, also modulate the risk of fatty liver [Citation103]. Diabetes has sometimes been described in some patients with monogenic hypocholesterolemia [Citation104], prompting the question of whether these patients are genetically predisposed to diabetes.

April 23, 2016 - Wheat fiber reduced serum cholesterol level by increasing the surface area for bile binding or altering the quantity of short-chain fatty acids [50]. Several studies have shown that propionate generated from dietary fibers containing polysaccharides exhibits hypocholesterolemic effects and offsets acetate generation, which tends to increase serum cholesterol via a mechanism probably involving liver lipogenesis [51], [52], [53], [54]. The reduction of cholesterol is possibly a sum of several effects; the most accepted one is decreased absorption of bile acids that causes removal of steroids from the body by fecal excretion, resulting in increased catabolism of cholesterol, an increase in the secretion of bile acids, a decrease in lipoprotein cholesterol secretion, and a reduction in the total body pool of cholesterol [55].

Clofibrate and related agents (bezafibrate, etofibrate, biclofibrate, lovastatin, and gemfibrozil) may induce a myopathy characterized by the acute onset of cramps, weakness, and tenderness, with an elevation of serum transaminases and CK. Myotonia may develop in some patients in response to hypocholesterolemic agents, especially clofibrate.

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Serum lipid profiles and antioxidant status were measured in addition to fecal neutral cholesterol and bile acids. AAE showed a remarkable hypocholesterolemic effect, improving antioxidant status, decreasing the level of total cholesterol and atherosclerosis index, increasing the level of high-density lipoprotein cholesterol and fecal excretion of bile acids.

Carla Carolina Munari, Pollyanna Francielli de Oliveira, Luis Fernando Leandro, Leandra Mara Pimenta, Natália Helen Ferreira, Juliana de Carvalho da Costa, Jairo Kenupp Bastos, Denise Crispim Tavares, 'In Vivo Assessment of Genotoxic, Antigenotoxic and Anticarcinogenic Activities of Solanum lycocarpum Fruits Glycoalkaloidic Extract', PLoS ONEhttps://journals.plos.org/plosone/article?id=10.1371/journal.pone.0111999 Apart from their obvious hypocholesterolemic action, statins have been shown to exert many cholesterol-independent, pleiotropic effects, related to inflammation, oxidative stress, thrombosis and vascular function.

August 14, 2025 - Hypocholesterolemic effect, according to the provided text, consistently refers to the ability of various substances to lower cholesterol levels in the bloodstream.

The hypocholesterolemic effect of the protein concentrates (PCs) prepared from Phaseolus angularis, Phaseolus calcaratus, and Dolichos lablab seeds relative to that of casein were studied in hamsters. Male Golden Syrian hamsters were fed test diets containing these proteins at 12% level for 30 days.

November 23, 2009 - A significant hypocholesterolemic effect was observed accompanied by a decrease in the accumulation of hepatic cholesterol (Table 5) and by lowered plasma TG and VLDL-C levels (Table 3).