Functional foods have hypocholesterolemic and antioxidant effects, also via decreasing homocysteine levels. Lowering blood cholesterol levels protects atherosclerosis. It was shown that functional foods such as vegetables, fruit fibers, fish oil, etc. have hypocholesterolemic effects and inhibit ...

March 10, 2026 - In the elderly, low cholesterol may confer a health risk that may not be offset by the beneficial effects of cholesterol lowering. Similarly, for elderly patients admitted to hospital, low cholesterol may predict short-term mortality. The prevalence of hypocholesterolemia in the elderly ranges ...

January 28, 2026 - Hypocholesterolemia may lead to mild liver dysfunction or fatty liver disease. You may also have problems with your eyes, brain, liver, muscles or bones. This comes from not having enough vitamin A, D, E or K in your body.

The hypocholesterolemic effects of plant sterols, fiber, Monascus products and soy protein preparations have been consistently demonstrated in clinical trails whereas the efficacy of some probiotic bacteria and phytoestrogens-containing supplements ...

In the placebo group and 10- and 20-g/d groups, the percent changes in total cholesterol were 0.4%, -5.8%, and -4.9%, in LDL cholesterol were -0.4%, -8.1%, and -7.3%, and in LDL/HDL were 1.0%, -5.6%, and -8.7%, respectively. The fiber supplement had no significant effects (P > 0.05) on HDL cholesterol or triglycerides.

August 23, 2022 - There has been some evidence that hypocholesterolemia can cause depression, suicidal ideation, and other effects on your mood or behavior.

Cholesterol biosynthesis enzyme HMG-CoA reductase is the target of most of the hypocholesterolemic drugs since it is the rate-limiting enzyme. However, myositis, gastrointestinal symptoms, pharyngitis, and pain are commonly associated side effects with these types of drugs.

Diets supplemented with oat products significantly lower serum cholesterol concentrations of humans (deGroot et al, 1963; Kirby et al., 1981; Judd and Truswell, 1981; Anderson et al., 1984b) and rats (Chen and Anderson, 1979). Since 1977 we have evaluated the hypocholesterolemic effects of oat bran; here we review these results in order to discuss the potential mechanisms involved for the cholesterol-lowering properties of soluble fibers.

November 23, 2009 - A significant hypocholesterolemic effect was observed accompanied by a decrease in the accumulation of hepatic cholesterol (Table 5) and by lowered plasma TG and VLDL-C levels (Table 3).

August 14, 2025 - Hypocholesterolemic effect, according to the provided text, consistently refers to the ability of various substances to lower cholesterol levels in the bloodstream.

April 23, 2016 - Wheat fiber reduced serum cholesterol level by increasing the surface area for bile binding or altering the quantity of short-chain fatty acids [50]. Several studies have shown that propionate generated from dietary fibers containing polysaccharides exhibits hypocholesterolemic effects and offsets acetate generation, which tends to increase serum cholesterol via a mechanism probably involving liver lipogenesis [51], [52], [53], [54]. The reduction of cholesterol is possibly a sum of several effects; the most accepted one is decreased absorption of bile acids that causes removal of steroids from the body by fecal excretion, resulting in increased catabolism of cholesterol, an increase in the secretion of bile acids, a decrease in lipoprotein cholesterol secretion, and a reduction in the total body pool of cholesterol [55].

There were no detrimental effects among the carriers. While many hypocholesterolemia cases have a monogenic origin (16–52%), a considerable proportion of such patients have polygenic hypocholesterolemia (34–50%) [Citation94–96], which is the result of the cumulative effects of common ...

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Several mechanisms of hypocholesterolemic action have been proposed. These include formation of mixed cholesterol-sitosterol crystals, competition for absorption sites, influence on cholesterol-rich micelles, competitive esterification, enhanced cholesterol excretion, and interference with cholesterol biosynthesis. Little work has been done in this area. Low-fat diets are unavoidably high in carbohydrates. The DELTA study (Dietary Effects on Lipids and Thrombogenic Activity) produced a variable, not statistically significant increase in triglyceride levels.

Hypocholesterolemic drugs (3-hydroxy-3-methylglutaryl–coenzyme A reductase inhibitors, or “statins”) lower the risk of both, BPH and prostate cancer [32,33]. Foods high in cholesterol and saturated fat are rich in arachidonic acid as well, which is the main precursor of inflammation.

Serum lipid profiles and antioxidant status were measured in addition to fecal neutral cholesterol and bile acids. AAE showed a remarkable hypocholesterolemic effect, improving antioxidant status, decreasing the level of total cholesterol and atherosclerosis index, increasing the level of high-density lipoprotein cholesterol and fecal excretion of bile acids.

February 6, 2024 - Beyond cardiovascular disease protection, the health consequences of very low concentrations of low-density lipoprotein-cholesterol (LDL-C) remain a matter of debate. In primary hypobetalipoproteinemia (HBL), liver steatosis and cirrhosis have ...

Patients with primary hypobetalipoproteinemias may manifest a variety of symptoms and signs affecting several organs (steatorrhea, neurological and ophalmological symptoms, non-alcoholic fatty liver disease) or be asymptomatic. Understanding hypocholesterolemia and the underlying molecular basis is of crucial importance since this may provide new insights in the treatment of hypercholesterolemia and cardiovascular disease.

May 1, 2010 - This suggests that HPMC supplementation affected both cholesterol and bile acid synthesis. Our data confirm that altered hepatic expression of lipid metabolism-related genes, possibly due to modulation of fecal bile acid excretion and intestinal cholesterol absorption, contributes to the lipid-lowering effects of HPMC.