February 19, 2024 - Natural products will play a vital part in supplying this need via the continuous exploration of global biodiversity, the majority of which remains unexplored. Even though drug discovery from medicinal plants remains an important source of novel therapeutic leads, various hurdles exist, including identifying and executing suitable high-throughput screening bioassays, scaling up the supply of bioactive molecules, and acquiring plant materials.

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January 28, 2021 - Fig. 5: Strategies to obtain natural product analogues with superior properties. ... Atanasov, A. G. et al. Discovery and resupply of pharmacologically active plant-derived natural products: a review. Biotechnol. Adv.

April 23, 2026 - Hao D-C, Wang Y-X, He C-N and Spjut RW (2023) Editorial: Plant-derived natural compounds in drug discovery: The prism perspective between plant phylogeny, chemical composition, and medicinal efficacy, volume II. Front. Plant Sci. 14:1324514. doi: 10.3389/fpls.2023.1324514 ... All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.

August 15, 2015 - On the contrary, natural products often have selective biological actions due to binding affinities for specific proteins relevant for their biological functions, possess superior chemical diversity and complexity developed during biosynthesis (Clardy and Walsh, 2004, Koehn and Carter, 2005), and often have more advantageous ADME/T properties. Particularly in the context of drug discovery from medicinal plants, a big advantage is that sometimes well documented ethnopharmacological information about the traditional use is available, which can provide hints for compounds therapeutically effective in humans (Corson and Crews, 2007, Heinrich, 2010a, Heinrich and Gibbons, 2001, Kinghorn et al., 2011).

August 24, 2024 - In particular, annotations of medicinal ... for many plants but also integrate practical modules for gene annotation and analysis to facilitate the exploration of natural sources for valuable chemical constituents, such as drug discovery and drug production. Annotations of biosynthetic and metabolic pathways within NP databases offer direct insights into the biotransformation processes of bioactive compounds. These annotations encompass details regarding the biosynthetic ...

October 18, 2022 - The development of phytopharmaceutical medicines is based on the ethnopharmacological approach, which relies on the traditional medicine system. The concept of ‘one-disease one-target drug’ is becoming less popular, and the use of plant extracts, fractions, and molecules is the new paradigm that holds promising scope to formulate appropriate drugs. This led to discovering a new concept known as polypharmacology, where natural products from varying sources can engage with multiple human physiology targets.

In work on a different class of plant natural products, Don Nguyen (previously O’Maille lab) has engineered enzymes from the Asteraceae family into yeast to generate oxygenated sesquiterpenes (Nguyen et al., 2016). During his time as an OpenPlant post-doc in the Martin lab, Yang Zhang, now a Principal Investigator at Sichuan University College of Life Sciences, used the HyperTrans system in the characterization of a new pathway for synthesis of root-specific ...

Rapid progress has been made in recent years in understanding natural product synthesis, regulation and function and the evolution of metabolic diversity. It is timely to bring this information together with contemporary advances in chemistry, plant biology, ecology, agronomy and human health to provide a comprehensive guide to plant-derived natural products.

January 6, 2022 - This review provides a comprehensive overview of various approaches used in the selection, authentication, extraction/isolation, biological screening, and analogue development through the application of modern drug-development principles of plant-based natural products.

April 26, 2024 - For instance, a highly cited article published in Nucleic Acids Research describes a web server, NRPSpredictor2, which uses machine learning methodology for improved substrate specificity predictions of natural product biosynthetic enzymes in bacteria. Plants and microbes produce natural products ...

RK type ginsenosides are rare saponins not naturally produced in plants. Here, the authors use genome assembly, comparative analysis, biochemical characterization and pathway reconstruction to show that Oplopanax elatus evolved a specialized dammaradienol synthase, enabling RK saponins de novo production in Nicotiana benthamiana.

Ayurvedic drug, forskolin. These and many other examples · serve to illustrate the continuing value of plant-derived

December 9, 2024 - Spongothymidine and spongouridine greatly enhanced the generation of nucleosides and eventually resulted in cytarabine (ara-C, arabinosylcytosine) production as an anti-leukemic drug and vidarabine as an antiviral agent (ara-A, arabinosyladenine) (Zöllinger et al., 2007). This review aims to explore the role of plant- and marine-derived natural products in modern drug discovery, focusing on their potential to treat life-threatening diseases such as cancer, cardiovascular disorders, and infectious diseases.

October 5, 2022 - Common examples include the18th-century description by Europeans of the discovery of aspirin in the leaves of the willow tree (genus Salix), having properties that reduce pain, fever, and inflammation (Ugurlucan et al., 2012). Similarly, Paclitaxel, a popular anticancer drug, that was first isolated from the bark and needles of Taxus brevifolia in 1971, and now approved by the FDA for the treatment of various types of cancer (Zhu and Chen, 2019). Even today, natural products derived from various plants species are still a valuable source of lead compounds, and this is inspiring a generation of scientists interested in the development and design of new therapeutic drugs (Katz and Baltz, 2016).

May 29, 2025 - These fractions are further analysed using analytical techniques (4) s to identify and elucidate (5) the specific compounds responsible for the observed bioactivity. ... Schematic illustration of classical and modern approaches to natural product (NP) discovery. Both begin with plant selection through random, ecological, or ethnopharmacological approaches.

In this Special Issue, we explore recent advances in plant-derived natural products and their biomedical properties via intriguing in vitro and in vivo research articles and literature reviews. Recently, Lantzouraki et al. showed that the extracts of two Artemisia species, Artemisia arborescens and Artemisia inculta Delile, from the Greek island of Crete exhibit an interesting profile of secondary metabolites [1]. More specifically...

Founded in 1995 at the University of Mississippi, NCNPR is the nation's premier university-affiliated research center dedicated to natural product innovation. We collaborate with regulatory agencies, academia, and industry partners to conduct comprehensive natural products research, encompassing taxonomy, plant physiology, pharmacognosy, analytical chemistry, pharmacology, and toxicity.

Rakotondraibe’s laboratory focuses on the investigation of these new natural product sources to discover novel pharmacophores of potential drug candidates. We routinely perform bioassay-guided isolation, structural elucidation and development of bioactive compounds from natural sources (higher ...