I just did this! It wasn't too bad. In my case I passed an NVidia P400 through to Docker in an Ubuntu 20.04 VM. The version of Ubuntu may matter for old GPUs. Here's my summary approach: 1) Prevent TrueNAS from using the device. 1a) From the TrueNAS shell, find the device: pciconf -lv You should see something like the following: vgapci1@pci0:131:0:0: class=0x030000 rev=0xa1 hdr=0x00 vendor=0x10de device=0x1cb3 subvendor=0x10de subdevice=0x11be vendor = 'NVIDIA Corporation' device = 'GP107GL \[Quadro P400\]' class = display subclass = VGA none146@pci0:131:0:1: class=0x040300 rev=0xa1 hdr=0x00 vendor=0x10de device=0x0fb9 subvendor=0x10de subdevice=0x11be vendor = 'NVIDIA Corporation' device = 'GP107GL High Definition Audio Controller' class = multimedia subclass = HDA You will need both the GPU device and the audio device. Note the IDs in the first part of each entry: vgapci1@pci0:131:0:0 none146@pci0:131:0:1 1b) Set system tuneables to exclude the device Add vmm_load with a value of YES Add ptdevs with a value of 131/0/0 131/0/1 (that is, the IDs found in step 1a above, separated with a space) 1c) Reboot TrueNAS 2) Prepare the VM OS (necessary for old GPUs) 2a. Once your Ubuntu VM is up and running, head to the shell and CD into /etc/modprobe.d/ cd /etc/modprobe.d/ 2b. Create a new file: sudo nano blacklist-nvidia-nouveau.conf 2c. Add the following to the new file then save/close: blacklist nouveau options nouveau modeset=0 2d. Create another new file: sudo nano nvidia.conf 2e. Add the following to the new file then save/close: options nvidia NVreg\_OpenRmEnableUnsupportedGpus=1 2f. Update kernel init ram fs: sudo update-initramfs -u 2g. Reboot the VM. 3) Add the GPU devices to the VM 3a. Shutdown the VM 3b. For each device: Click Devices, Add, Change the device to PCI Passhthrough, select the device. I believe the order needs to be unique. 3c. Reboot the VM 4) Install the NVidia drivers and Utilities sudo apt install nvidia-driver-460-server sudo apt install nvidia-utils-460-server 5) Verify that the VM OS can access the GPU. nvidia-smi will return a table of output if the GPU is found. lspci | grep NVIDIA nvidia-smi The GPU is now available to the VM. Continue if you want to pass the GPU through to Docker. 6) Install Docker 7) Install the NVidia Container Toolkit distribution=$(. /etc/os-release;echo VERSION\_ID) \\ && curl -s -L [https://nvidia.github.io/libnvidia-container/gpgkey] \\ (https://nvidia.github.io/libnvidia-container/gpgkey) | sudo apt-key add - \\ && curl -s -L https://nvidia.github.io/libnvidia-container/$distribution/libnvidia-container.list | sudo tee /etc/apt/sources.list.d/nvidia-container-toolkit.list sudo apt-get update && sudo apt-get install -y nvidia-container-toolkit 8) Verify that the GPU can be accessed from Docker. sudo ctr image pull docker.io/nvidia/cuda:11.0.3-base-ubuntu20.04 sudo ctr run --rm -t \\ --runc-binary=/usr/bin/nvidia-container-runtime \\ --env NVIDIA\_VISIBLE\_DEVICES=all \\ docker.io/nvidia/cuda:11.0.3-base-ubuntu20.04 \\ cuda-11.0.3-base-ubuntu20.04 nvidia-smi I am deeply indebted to craftycraft who covered most of this in the TrueNAS community thread listed below. I only had to make minor modifications to his approach in order to make this work for me. Resources: https://docs.nvidia.com/ai-enterprise/deployment-guide-vmware/0.1.0/nouveau.html https://www.truenas.com/community/threads/guide-nvidia-quadro-p400-gpu-passthrough-to-vm-and-docker-for-jellyfin-transcoding.104750/ https://ubuntu.com/server/docs/nvidia-drivers-installation Answer from raw65 on reddit.com