C-Jun N-terminal kinases

May 30, 2024 - Activation occurs through a dual phosphorylation of threonine (Thr) and tyrosine (Tyr) residues within a Thr-Pro-Tyr motif located in kinase subdomain VIII. Activation is carried out by two MAP kinase kinases, MKK4 and MKK7, and JNK can be inactivated by Ser/Thr and Tyr protein phosphatases.

JNK subfamily in the IUPHAR/BPS Guide to PHARMACOLOGY.

The c-Jun N-terminal kinases (JNKs), as members of the mitogen-activated protein kinase (MAPK) family, mediate eukaryotic cell responses to a wide range of abiotic and biotic stress insults. JNKs also regulate important physiological processes, including ...

SAPK/JNK according to its full name (i.e., stress-activated protein kinase/Jun N-terminal kinase), SAPK/JNK is a serin–threonine kinase which is activated by cellular stress and which phosphorylates the amino-terminal domain of the Jun transcription factor.

Nishina H, Wada T, Katada T. Physiological roles of SAPK/JNK signaling pathway[J]. Journal of biochemistry, 2004, 136(2): 123-126.

September 30, 2020 - Proteins play a plethora of roles within biological organisms critical to their optimal function and health. This article will discuss the JNK protein.

Keeping in mind that JNK3 is ... it is possible to hypothesize that inhibition of JNK3 might be considered as a potential target for treating neurodegenerative mechanisms associated with AD. Since its discovery more than 20 years ago, the c-Jun N-terminal kinase family (JNK) has remained a subject of intense research interest with continued efforts to evaluate its biochemistry and regulation, ...

The extracellular signal-regulated kinase (ERK), the c-Jun NH[2] -terminal kinase (JNK), and p38 MAP kinase pathways are triggered upon ligation of the antigen-specific T cell receptor (TCR). During the development of T cells in the thymus, the ERK pathway ...

This article is part of the Research Topic Proceedings from ACCM19: Cell Cycle, DNA Damage Response and Telomeres View all 12 articles · John E. La Marca*Helena E. Richardson · Richardson Laboratory, Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, VIC, Australia · The highly conserved c-Jun N-terminal Kinase (JNK...

Mailing address: Cell Signalling Laboratory, Biochemistry and Molecular Biology (M310), School of Biomedical, Biomolecular and Chemical Sciences, University of Western Australia, 35 Stirling Highway, Crawley, Western Australia 6009, Australia. Phone: 61 8 6488 1348. Fax: 61 8 6488 1148. E-mail: ua.ude.awu.enellyc@beiram. The c-Jun N-terminal kinases (JNKs...

From JNK to pay dirt: jun kinases, their biochemistry, physiology and clinical importance.

Jun N-terminal kinases or JNKs play a critical role in death receptor-initiated extrinsic as well as mitochondrial intrinsic apoptotic pathways. JNKs activate apoptotic signaling by the upregulation pro-apoptotic genes via the transactivation of specific ...

The c-Jun N-terminal kinases (JNKs) were originally identified by their ability to phosphorylate c-Jun in response to UV-irradiation, but now are recognized as critical regulators of various aspects of mammalian physiology, including: cell proliferation, cell survival, cell death, DNA repair ...

c-Jun N-terminal kinases (JNKs) are among the most crucial mitogen-activated protein kinases (MAPKs) and regulate various cellular processes, including cell proliferation, apoptosis, autophagy, and inflammation. Microbes heavily rely on cellular signaling ...

Several primary murine and human B lymphomas and cell lines were found to constitutively express high levels of the activated form of c-jun N-terminal kinase (JNK), a member of the mitogen-activated protein (MAP) kinase family. Proliferation of murine ...

Karin, M. & Gallagher, E. From JNK to pay dirt: jun kinases, their biochemistry, physiology and clinical importance.

From JNK to pay dirt: jun kinases, their biochemistry, physiology and clinical importance. Karin M, Gallagher E. Karin M, et al. IUBMB Life. 2005 Apr-May;57(4-5):283-95. doi: 10.1080/15216540500097111. IUBMB Life. 2005. PMID: 16036612 Review. The isoform-specific functions of the c-Jun N-terminal ...

The c-Jun NH2-terminal kinases (JNKs) are an evolutionarily conserved sub-group of mitogen-activated protein (MAP) kinases. Recent studies have improv…

JNK is a key regulator of many cellular events, including programmed cell death (apoptosis). In the absence of NF-κB activation, prolonged JNK activation contributes to TNF-α induced apoptosis. JNK is also essential for UV induced apoptosis. However, recent studies reveal that JNK can suppress ...