A variety of studies have been evaluated the role of miRNAs in the development and cyclic changes of hair. It is well-documented that miRNAs play a vi…

The exact pathogenic mechanism causes hair miniaturization during androgenic alopecia (AGA) has not been delineated. Recent evidence has shown a role …

Hair follicle development is closely associated with wool curvature. Current studies reveal the crucial role of microRNAs (miRNAs) in hair follicle growth and development. However, few studies are known regarding their role in wool curvature. To reveal ...

As one of the main appendages of skin, hair follicles play an important role in the process of skin regeneration. Hair follicle is a tiny organ formed by the...

Skin development is governed by complex programs of gene activation and silencing, including microRNA-dependent modulation of gene expression. Here, we show that miR-214 regulates skin morphogenesis and hair follicle (HF) cycling by targeting β-catenin, ...

In mice lacking thyroid hormone receptors, bulge stem cells of the hair follicles present epigenetic alterations and a functional defect in their mobilization out of the niche. This is related to aberrant activation of Smad signaling and reduced nuclear ...

The identification of transcriptional activators and repressors of hair cell fates has recently been augmented by the discovery of microRNAs (miRNAs) that can function as post-transcriptional repressors in sensory hair cells.miRNAs are ~21 nucleotide ...

Clinical conditions causing hair loss, such as androgenetic alopecia, alopecia areata, and scarring alopecia, can be psychologically devastating to in…

Alopecia is a common problem that affects almost every age group and is considered to be an issue for cosmetic or psychiatric reasons. The loss of hair folli...

August 8, 2020 - A recent study has identified a microRNA that could help reverse hair loss. The findings could lead to more effective, less time-consuming interventions.

June 27, 2023 - Scientists may have discovered a breakthrough treatment that could help reverse hair loss by using microRNA.

July 20, 2014 - Request PDF | The regulatory mechanism of microRNAs in skin and hair follicle development | MicroRNAs (miRNAs) are an emerging class of regulators that control post-transcriptional processes, and could be potential targets for drug in... | Find, read and cite all the research you need on ...

Hair follicle morphogenesis depends on Wnt, Shh, Notch, BMP and other signaling pathways interplay between epithelial and mesenchymal cells. The Wnt pathway plays an essential role during hair follicle induction, Shh is involved in morphogenesis and ...

Background Human hair follicle (HF) cycling is characterised by the tight orchestration and regulation of signalling cascades. Research shows that micro(mi)RNAs are potent regulators of these pathways. However, knowledge of the expression of miRNAs and their target genes and pathways in the ...

A new study shows that increased microRNA-31 expression is associated with hair follicle aging. Genetic deletion of the microRNA or pharmacological inhibition of its downstream effectors suppresses hair follicle stem cell aging in mice.

Hair follicle development and its postnatal regeneration are characterized by dramatic changes in its microanatomy and cellular activity, which are controlled by multiple signalling pathways, transcription factors and epigenetic regulators, including microRNAs (miRNAs). miRNAs and their targets ...

Background Merino sheep exhibit high wool production and excellent wool quality. The fleece of Merino sheep is predominantly composed of wool fibers grown from hair follicles (HFs). The HF is a complex biological system involved in a dynamic process governed by gene regulation, and gene expression ...

Hair follicle stem cells (HFSCs) reside in the bulge region of the outer root sheath of the hair follicle. They are considered slow-cycling cells that are endowed with multilineage differentiation potential and superior proliferative capacity. The normal ...

June 5, 2023 - This new miRNA plays an important role in regulating the pathway involved in follicle regeneration, and could be a candidate for future drug development.