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Data on the mechanism of toxicity and tumorigenicity of chloroform suggest that the tumorigenic response occurs at concentrations that cause cell death and proliferative cellular regeneration. Thus, a linear low-dose extrapolation for cancer risk might not be appropriate.

It is released from pulp and paper mills, hazardous waste sites, chlorinated water, and certain landfills. Chloroform is used in some refrigerants, solvents, and chemical manufacturing. Some examples of workers at risk of being exposed to chloroform include the following:

March 30, 2023 - People who work with chloroform are at a greater risk. In general, people may also be exposed by inhaling the chemical as they do laundry or bathe with contaminated water.

Human health risk assessment is used to evaluate the effects of a chemical or substance (contaminant) on human health using the best available scientific information. The guidance values developed through the risk assessment process are used by government agencies, policymakers, and the public ...

This substance is now primarily used in laboratory settings and in the manufacturing of various industrial products.[1][2] Due to its toxicity and associated health risks, chloroform is considered a hazardous substance, and it falls under strict regulatory oversight by governmental agencies ...

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International Agency for Research on Cancer. 1972. Chloroform. In IARC Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Man. Volume 1. Lyon, France: International Agency for Research on Cancer.

August 6, 2024 - Chloroform is used in pesticide formulations, as a solvent and chemical intermediate in laboratories and industry, as a cleansing agent, in the production of dyes, in fire extinguishers and in the pharmaceutical and rubber industries.

Risk assessment methodology, particularly pertaining to potential human carcinogenic risks from exposures to environmental chemicals, is undergoing in…

The International Agency for Research on Cancer (IARC 1999) concluded that a causal relationship between cancer and chloroform could not be inferred, because of the use of indirect methods of assessing exposure, incomplete control for confounding by exposure to other water impurities or other risk ...

Exposure to chloroform can occur when breathing contaminated air or when drinking or touching the substance or water containing it. Breathing chloroform can cause dizziness, fatigue, and headaches. Breathing chloroform or ingesting chloroform over long periods of time may damage your liver ...

When you think of chloroform, your ... with chloroform-soaked cloth. Doctors in the 1850s also used it as an anesthetic on patients before surgery. So, it might come as a surprise – it did for me – to learn it’s a common contaminant in the drinking water that serves roughly 220 million people in 46 states, even though it harms the nervous system and increases the risk of ...

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Risk assessment methodology, particularly pertaining to potential human carcinogenic risks from exposures to environmental chemicals, is undergoing intense scrutiny from scientists, regulators, and legislators. The current practice of estimating human cancer risk is based almost exclusively ...

ATSDR developed this Completed Exposure Pathway List to track the substances to which people have been exposed at hazardous waste sites. It was updated as part of the Priority List of Hazardous Substances for 2001.

Main Webpage for the Division of Public Health (DPH).

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In late 2012, The Dr. John T. Macdonald Foundation Biomedical Nanotechnology Institute of University of Miami (BioNIUM) was established at the University of Miami with the generous philanthropic support of $7.5 Million by the Dr. John T. Macdonald Foundation, with additional equivalent supporting ...