Anaplastic lymphoma kinase (Alk) is a receptor tyrosine kinase of the insulin receptor super-family that functions as oncogenic driver in a range of human cancers such as neuroblastoma. In order to investigate mechanisms underlying Alk oncogenic signaling, ...

Sustained JNK activation plays a critical role in hepatotoxicity by acetaminophen or GalN/TNF-α. To address the importance of JNK translocation to mitochondria that accompanies sustained activation in these models, we assessed the importance of ...

September 1, 2016 - The c-Jun N-terminal kinases (JNKs), as members of the mitogen-activated protein kinase (MAPK) family, mediate eukaryotic cell responses to a wide range of abiotic and biotic stress insults. JNKs also regulate important physiological processes, including neuronal functions, immunological actions, ...

Background: Little is known about the role for JNK mitochondrial signaling in neuronal cell death.Results: Global and mitochondrial inhibition of JNK protects against 6-OHDA-induced neuronal loss in the SNpc.Conclusion: Blocking JNK mitochondrial translocation ...

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Stress-activated c-Jun N-terminal kinases (JNKs) are members of mitogen-activated protein kinases (MAPKs). Apart from having both tumor promoting and tumor suppressing roles in cancers due to its impact on apoptosis and autophagy pathways, JNK also plays ...

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July 26, 1999 - Biochemistry is the study of the chemical substances and processes that occur in plants, animals, and microorganisms and of the changes they undergo during development and life.

The Jun N-terminal kinase (JNK) pathway is an evolutionary conserved kinase cascade best known for its roles during stress-induced apoptosis and tumor progression. Recent findings, however, have identified new roles for this pleiotropic pathway in stem cells during regenerative responses and ...

© 2016 by The American Society for Biochemistry and Molecular Biology, Inc. JNK-Interacting Protein 3 Mediates the Retrograde Transport of Activated c-Jun N-Terminal Kinase and Lysosomes ... Drerup, Catherine M.; Nechiporuk, Alex V. ... Retrograde axonal transport requires an intricate interaction between the dynein motor and its cargo. What mediates this interaction is ...

FLAG-NLRC4 and FLAG-NLRP3 were ... of Biochemistry, University of Lausanne, Switzerland), respectively. GFP-NOD2 was generated by PCR using the GFP Fusion TOPO® TA expression kit (Invitrogen) from HA-NOD2. GFP-NOD2-V5 was generated by PCR using the pLenti6/V5 Directional TOPO® cloning kit (Invitrogen) from GFP-NOD2. JNKBP1-V5 was generated ...

Deregulation of c-Jun NH[2] -terminal kinase (JNK) signaling occurs frequently in a variety of human cancers, yet the exact role(s) of JNK deregulation in cancer cell biology remains to be fully elucidated. Our recent demonstration that the activity of ...

Looking for the definition of JNK? Find out what is the full meaning of JNK on Abbreviations.com! 'c-Jun NH2-terminal Kinase' is one option -- get in to view more @ The Web's largest and most authoritative acronyms and abbreviations resource.

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Inhibitors on JNK Signaling Pathway are available at Selleck. Check JNK reviews and assay information.