Evidence has established the protective effect of folic acid (FA) fortification and periconceptional supplementation on neural tube defects (NTDs). Folic acid fortification and periconceptional supplementation of women may reduce the risk of certain childhood cancers in their offspring.

The American Academy of Pediatrics endorses the US Public Health Service (USPHS) recommendation that all women capable of becoming pregnant consume 400 microgram of folic acid daily to prevent neural tube defects (NTDs). Studies have demonstrated that periconceptional folic acid supplementation ...

June 21, 2023 - Folic acid is vital for pregnant women especially during early pregnancy to prevent neural tube defects and spine and brain defects in the unborn baby.

Kim H, et al. Nutr Res Pract. 2020 Aug;14(4):309-321. https://doi.org/10.4162/nrp.2020.14.4.309

Autism spectrum disorders (ASD) are recognized as a major public health issue. Here, we evaluated the effects of folic acid intervention on methylation cycles and oxidative stress in autistic children enrolled in structured teaching. Sixty-six autistic children enrolled in this open-label trial ...

Folate is an essential water-soluble vitamin, naturally present in food, especially in fruits, green leafy vegetables, and liver.[1][2] Folic acid is the synthesized form of folate present in fortified foods and supplements and has a higher bioavailability than naturally occurring folate.

Maternal folic acid (FA) supplementation is one of the most popular nutritional

Folic acid supplements have been considered as safe. A combined analysis from 2009 of two Norwegian randomized controlled clinical trials, with extended post-trial follow-up, demonstrated however, an increased incidence of cancer among patients taking folic acid for homocysteine reduction as ...

Background Current data indicate that supplements such as folic acid and vitamin B may be beneficial in halting and even reversing atrophic gastritis, intestinal metaplasia and intraepithelial neoplasia, generally referred to as gastric precancerous conditions(GPC).

Folic acid (vitamin B9) is a water-soluble vitamin used to manage and treat megaloblastic anemia. Folic acid has FDA approval for treating megaloblastic and macrocytic anemias due to folic deficiency. This activity describes the indications, mechanism of action, and contraindications for folic ...

June 7, 2022 - ### What you need to know Neural tube defects are fatal or disabling birth defects resulting from failure of the neural tube to close approximately 21-28 days after conception.1 Neural tube defects, which include spina bifida, anencephaly and encephalocele, are common congenital anomalies estimated ...

A fortification programme that delivered 400 micrograms folic acid daily to women would protect against NTD, but at the expense of unnecessarily high exposure for many people. Delivery of 200 micrograms daily is also effective against NTD and safer for the general population.

May 15, 2024 - Learn about folic acid, its benefits, and role in preventing neural tube defects.

May 31, 2018 - Formate supplementation prevents most folic acid-resistant neural tube defects in mice.

To assess the benefits and harms of folic acid supplementation in reproductive-age women for the prevention of neural tube defects (NTDs).

Hyperhomocysteinemia, a condition of elevated blood homocysteine (Hcy) levels, is a metabolic disease. It is a common clinical finding in patients with chronic kidney diseases and occurs almost uniformly in patients with end-stage renal disease. Hyperhomocysteinemia is also a risk factor for ...