JNK is named after c-Jun N-terminal kinase, as it is responsible for phosphorylating c-Jun. As a member of the mitogen-activated protein kinase (MAPK) family, JNK is also known as stress-activated kinase (SAPK) because it can be activated by extracellular stresses including growth factor, UV ...

The JNK proteins are activated by multiple and diverse stimuli, leading to varied and seemingly contradictory cellular responses. In particular, JNKs have been reported to have a role in the induction of apoptosis, but have also been implicated in enhancing ...

This review extensively reports data from the literature concerning the complex relationships between the stress-induced c-Jun N-terminal kinases (JNKs) and the four main cytoskeleton elements, which are actin filaments, microtubules, intermediate filaments, ...

December 1, 2006 - SUMMARY The c-Jun N-terminal kinases (JNKs) are members of a larger group of serine/threonine (Ser/Thr) protein kinases from the mitogen-activated protein kinase family. JNKs were originally identified as stress-activated protein kinases in the livers of cycloheximide-challenged rats.

c-Jun N-terminal protein kinases (JNK), also known as stress-activated protein kinases, were originally identified by their ability to phosphorylate the N-terminal of the transcription factor c-Jun and by their activation in response to a variety of stresses.

From JNK to pay dirt: jun kinases, their biochemistry, physiology and clinical importance. Karin M, Gallagher E. Karin M, et al. IUBMB Life. 2005 Apr-May;57(4-5):283-95. doi: 10.1080/15216540500097111. IUBMB Life. 2005. PMID: 16036612 Review. ... Research Support, Non-U.S. Gov't ... The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). Unauthorized use of these marks is ...

The signaling pathway mediated by JNK transduces different types of signals, such as stress stimuli and cytokines, into functional responses that mediate apoptosis, as well as proliferation, differentiation, and inflammation. To better characterize the ...

Department of Biochemistry and Molecular Biology, Howard Hughes Medical Institute, Program in Molecular Medicine, University of Massachussetts Medical School, Worcester, Massachusetts 01605, USASearch for articles by this author · Open ArchiveDOI:https://doi.org/10.1016/S0092-8674(00)00116-1 · Signal Transduction by the JNK ...

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August 19, 2019 - Biochemistry is the application of chemistry to the study of biological processes at the cellular and molecular level. It emerged as a distinct discipline around the beginning of the 20th century when scientists combined chemistry, physiology, and biology to investigate the chemistry of living ...

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c-Jun-N-terminal kinase (JNK) activity plays a critical role in modulating cell death, which depends on the level and duration of JNK activation. The kinase cascade from MAPkinase kinase kinase (MAP3K) to MAPkinase kinase (MAP2K) to MAPKinase (MAPK) can be regulated by a number of direct and ...

c-Jun N-terminal kinases (JNKs) participate in cellular responses to mitogenic stimuli, environmental stresses, and apoptotic agents. The mechanisms b…

Acetaminophen (APAP) overdose induces severe liver injury and hepatic failure. While the activation of c‐Jun NH[2] ‐terminal kinase (JNK) has been implicated as a mechanism in APAP‐induced liver injury, the hepatic defense system ...

Translation is a costly, but inevitable, cell maintenance process. To reduce unnecessary ATP consumption in cells, a fine-tuning mechanism is needed for both ribosome biogenesis and translation. Previous studies have suggested that the ribosome functions ...

July 20, 2022 - How do metabolic activities take place? Yes, you will get to know all these life processes through ‘Biochemistry.’ · The branch of science dealing with the study of all the life processes such as control and coordination within a living organism is called Biochemistry.

Previously, we demonstrated JNK plays a central role in acetaminophen (APAP)-induced liver injury (Gunawan, B. K., Liu, Z. X., Han, D., Hanawa, N., Gaarde, W. A., and Kaplowitz, N. (2006) Gastroenterology 131, 165–178). In this study, we examine ...

Anaplastic lymphoma kinase (Alk) is a receptor tyrosine kinase of the insulin receptor super-family that functions as oncogenic driver in a range of human cancers such as neuroblastoma. In order to investigate mechanisms underlying Alk oncogenic signaling, ...