Nutrients, an international, peer-reviewed Open Access journal.

This is a protocol for a Cochrane Review (intervention). The objectives are as follows:To assess the benefits and the potential adverse effects, including cancer, of folate supplementation, either in folic acid form or in 5‐methyltetrahydrofolate ...

It has been conclusively established that folic acid supplementation prior to and during early pregnancy (up to 12 weeks of gestation) can prevent neural tube defects (NTDs). We hypothesized that folate effects may extend from neuro-structural defects ...

Folic acid (FA), with its anti-inflammatory and antioxidant properties, may offer protection against ischemia–reperfusion (IR) injury. This study investigated whether FA safeguards rat kidneys from IR by targeting high mobility group box-1 (HMGB1), a key inflammatory mediator.

We are entering a new era in preventive medicine, which focuses on diet as a means to health. Folate has received much attention as a vitamin that can protect against many diseases, but do we know enough about the long term effects of supplementation? ...

Neural tube defects (NTDs) are among the most common birth defects in the United States.

Morgan SL, Baggott JE, Vaughn WH, Young PK, Austin JV, Krumdieck CL, Alarcón GS. The effect of folic acid supplementation on the toxicity of low-dose methotrexate in patients with rheumatoid arthritis. Arthritis Rheum. 1990 Jan;33(1):9–18.

January 30, 2023 - Folic acid is a synthetic form of folate, an essential B vitamin, found in dietary supplements and fortified foods. Folic acid reduces the risk of neural tube defects (NTDs) when used in early pregnancy, treats certain types of anemia, and reduces levels of homocysteine, the latter of which ...

Folate, an essential B-vitamin found in leafy green vegetables, citrus, and lentils supplies one-carbon (methyl) moieties that drive methylation reactions in the body. A synthetic and more highly bioavailable form of folate, folic acid, is found in vitamin supplements as well as in some enriched ...

BACKGROUND: The efficacy of treatments that lower homocysteine concentrations in reducing the risk of cardiovascular disease remains contr

The US CDC and the Institute of Medicine recommend that women capable of becoming pregnant consume ≥400 μg synthetic folic acid/d to prevent neural tube defects (NTDs). The United States has 3 sources of folic acid: fortified enriched ...

This study aimed to evaluate whether folic acid supplementation would improve cognitive performance by reducing serum inflammatory cytokine concentrations. This RCT was performed in Tianjin, China. Participants with mild cognitive impairment (MCI) were ...

For over a decade, folic acid (FA) supplementation has been widely prescribed to pregnant women to prevent neural tube closure defects in newborns. Although neural tube closure occurs within the first trimester, high doses of FA are given throughout pregnancy, the physiological consequences ...

Women and men need this vitamin to support their heart and nervous system. Find out how much you should be consuming.

Objective: To determine the size of reduction in homocysteine concentrations produced by dietary supplementation with folic acid and with vitamins B-12 or B-6. Design: Meta-analysis of randomised controlled trials that assessed the effects of folic acid ...

Learn about Folic acid in diet or find a doctor at Mount Sinai Health System.

The nutritional status of women prior to and during pregnancy plays a key role in fetal growth and development. Poor nutritional status in a woman in the period before she conceives and in early pregnancy (up to 12 weeks gestation),may increase the risk for adverse pregnancy outcomes.

Background Endothelial dysfunction serves as an early marker for the risk of cardiovascular disease (CVD); therefore, it is an attractive site of therapeutic interventions to reduce the risk of CVD. This study was conducted to investigate the effect of folic acid supplementation on endothelial ...

Evidence has established the protective effect of folic acid (FA) fortification and periconceptional supplementation on neural tube defects (NTDs). Folic acid fortification and periconceptional supplementation of women may reduce the risk of certain childhood cancers in their offspring.

The American Academy of Pediatrics endorses the US Public Health Service (USPHS) recommendation that all women capable of becoming pregnant consume 400 microgram of folic acid daily to prevent neural tube defects (NTDs). Studies have demonstrated that periconceptional folic acid supplementation ...