There are considerable difficulties in determining the most effective dose, form, and timing of folic acid supplementation for prevention of first NTDs. RCTs provide the best opportunity to make these determinations, but there has only been a single RCT assessing women without a history of ...

Maternal folic acid (FA) supplementation is one of the most popular nutritional interventions during pregnancy for its protective effect against neural tube defects (NTDs).The purposes of this review are: (a) to gather the current evidence regarding supplementation ...

AMPK is an endogenous energy sensor that regulates lipid and carbohydrate metabolism. Nonalcoholic fatty liver disease (NAFLD) is regarded as a hepatic manifestation of metabolic syndrome with impaired lipid and glucose metabolism and increased oxidative ...

Maternal folic acid (FA) supplementation is one of the most popular nutritional interventions during pregnancy for its protective effect against neura…

Background: Folate is a water-soluble vitamin and is essential for maintaining cell functions. Dialysis removes folate, and folate deficiency is reported in patients with end-stage kidney disease (ESKD). However, there is no consensus as to the appropriate dosage of folate supplements and their ...

The blockade of purine nucleotide biosynthesis by MTX at the AICA ribonucleotide transformylase-catalyzed step may be related to the efficacy of MTX, and this blockade is effectively relieved by folinic acid, but not by folic acid, supplementation.

The present study investigated the effect of folic acid supplementation on the Notch signaling pathway and cell proliferation in rat embryonic neural stem cells (NSCs). The NSCs were isolated from E14-16 rat brain and grown as neurospheres in serum-free suspension culture.

more detailed investigations into the health benefits of folic acid are needed before it could be recommended for supplementation, treatment or prevention of some of the diseases discussed in this review.

Background: Folic acid supplementation in patients with folic acid deficiency has been associated with increased clearance of phenytoin to its cytochr…

Folinic acid, also known as 5-formyl tetrahydrofolic acid or leucovorin, treats various cancers when employed with 5-fluorouracil (5-FU). Additionally, leucovorin serves as an antidote to folic acid antagonists like methotrexate. Folinic acid's properties allow it to function as an antidote, ...

The Agency for Healthcare Research and Quality (AHRQ) requested a limited update to a previous review on folic acid supplementation to prevent neural tube defects (NTDs).1 The U.S. Preventive Services Task Force (USPSTF) will use this report to update its 2017 recommendation on this topic.2 ...

Folic acid, an inexpensive vitamin, is safe in a broad range of doses and protects patients with rheumatoid arthritis who are taking methotrexate from toxicity while preserving the efficacy of methotrexate.

May 9, 2024 - Folate is naturally found in many foods, and is also added to foods and sold as a supplement in the better-absorbed form of folic acid.

March 1, 2008 - During our reproductive years, extra folic acid is essential. After that, it may be too much.Folic acid is a synthetic form of folate, a B vitamin found naturally in various fruits, vegetables, and legumes. We need folate to produce and maintain new cells (in particular, red blood cells) and ...

Inadequate folate intake during pregnancy is the leading cause of the development of neural tube defects (NTDs) in newborns. For this reason, mandatory fortification of folic acid, a synthetic, easily bioavailable form, in processed cereals and cereal products has been implemented in the US ...

We aimed to systematically assess the relationship between folic acid supplementation in pregnancy and risk of preeclampsia and gestational hypertension.The relevant studies were included by retrieving the Embase, PubMed and Cochrane library databases. ...

This study aimed to evaluate whether folic acid supplementation would improve cognitive performance by reducing serum inflammatory cytokine concentrations. This RCT was performed in Tianjin, China. Participants with mild cognitive impairment (MCI) were randomly assigned to the folic acid (400 ...

The present study aimed to evaluate the effects of folic acid supplementation in high-fructose-induced hepatic steatosis and clarify the underlying mechanism of folic acid supplementation.Male SD rats were fed control, 64% high-fructose diet, or 64% high-fructose ...

Neural tube defects (NTDs), a common birth defect in humans, result from the failure of the embryonic neural tube (NT) to close properly. NT closure is a complex, poorly understood morphogenetic process influenced by genes and environment. The most effective environmental influence in decreasing ...

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