The c-Jun amino-terminal kinase (JNK) is an important player in inflammation, proliferation, and apoptosis. More recently, JNK was found to regulate cell migration by phosphorylating paxillin. Here, we report a novel role of JNK in cell adhesion. Specifically, ...

The c-Jun-NH2-terminal kinase (JNK) signaling pathway plays a critical role in regulating cell fate, being implicated in a multitude of diseases rangi…

The international journal of biochemistry & cell biology 33, 1047–1063 (2001). ... Weston, C. R. & Davis, R. J. The JNK signal transduction pathway. Current opinion in cell biology 19, 142–149, doi:10.1016/j.ceb.2007.02.001 (2007). ... Kato, T. et al. Distinct role of c-Jun N-terminal kinase isoforms ...

These JIP-derived peptides inhibitors ... kinetic mechanism of JNK2 [82]. The results have provided important insights into the biochemistry of JNK including that protein substrate binding is primarily due to the distal contacts in the JNK2 docking groove, that there is minimal ...

August 8, 2023 - Activation occurs through a dual phosphorylation of threonine (Thr) and tyrosine (Tyr) residues within a Thr-Pro-Tyr motif located in kinase subdomain VIII. Activation is carried out by two MAP kinase kinases, MKK4 and MKK7, and JNK can be inactivated by Ser/Thr and Tyr protein phosphatases.

The mitogen-activated kinases JNK1/2/3 are key enzymes in signaling modules that transduce and integrate extracellular stimuli into coordinated cellul…

c-Jun N-terminal kinases (JNKs) are among the most crucial mitogen-activated protein kinases (MAPKs) and regulate various cellular processes, including cell proliferation, apoptosis, autophagy, and inflammation. Microbes heavily rely on cellular signaling pathways for their effective replication; ...

From JNK to pay dirt: jun kinases, their biochemistry, physiology and clinical importance.

c-Jun NH[2] -terminal Kinases (JNKs) play a central role in the cellular response to a wide variety of stress signals. After their activation, JNKs induce phosphorylation of substrates, which control proliferation, migration, survival, and differentiation. ...

February 6, 2023 - Deregulated cell fate specification pathways, including oncogenic Ras, cause activation of JNK-signaling at contact sites with wild type cells, which drives apoptosis and aberrant cell elimination in a contact-dependent manner.

Because understanding the modes ... catalytic mechanisms and substrates, recent advances in these areas of JNK biochemistry are also considered. In addition, the use of JNK gene knockout animals is continuing to reveal in vivo functions for these kinases, with tissue-specific ...

Keeping in mind that JNK3 is ... it is possible to hypothesize that inhibition of JNK3 might be considered as a potential target for treating neurodegenerative mechanisms associated with AD. Since its discovery more than 20 years ago, the c-Jun N-terminal kinase family (JNK) has remained a subject of intense research interest with continued efforts to evaluate its biochemistry and regulation, ...

Department of Biochemistry and Molecular Biology, Oregon Health Sciences University, Portland, 97201-3098, Oregon, OR, USA · Jacob L Todd, Johanna D Rigas, Louise A Rafty & John M Denu ... Correspondence to John M Denu. ... Todd, J., Rigas, J., Rafty, L. et al. Dual-specificity protein tyrosine phosphatase VHR down-regulates c-Jun N-terminal kinase (JNK). Oncogene 21, 2573–2583 (2002). https://doi.org/10.1038/sj.onc.1205344 ... Sorry, a shareable link is ...

Ember, B., Kamenecka, T. & LoGrasso, P. Kinetic mechanism and inhibitor characterization for c-jun-N-terminal kinase 3alpha1. Biochemistry 47, 3076–3084; 10.1021/bi701852z (2008). ... Zhao, Y. & Herdegen, T. Cerebral ischemia provokes a profound exchange of activated JNK isoforms in brain ...

Different c-Jun N-terminal kinases (JNKs) are activated by a plethora of signals and phosphorylate substrates such as c-Jun, which is required for eff…

From JNK to pay dirt: jun kinases, their biochemistry, physiology and clinical importance.

Lisnock J, Griffin P, Calaycay ... alpha 1. Biochemistry. 2000;39:3141–8. [PubMed] [Google Scholar] 15. Wada T, Nakagawa K, Watanabe T, Nishitai G, Seo J, Kishimoto H, Kitagawa D, Sasaki T, Penninger JM, Nishina H, Katada T. Impaired synergistic activation of stress-activated protein kinase SAPK/JNK in mouse embryonic stem cells lacking SEK1/MKK4: different contribution of SEK2/MKK7 isoforms to the synergistic ...

Monoclonal Anti-JNK, Activated (Diphosphorylated JNK) antibody produced in mouse (Monoclonal Anti-JNK, Activated (Diphosphorylated JNK)); monoclonal JNK-PT48, ~ 2mg/mL, purified immunoglobulin, buffered aqueous solution; Suitable for indirect ELISA; Monoclonal Anti-JNK, Activated (Diphosphorylated J

Publisher: Korean Society for Biochemistry and Molecular Biology - BMB Reports

We used both a gene knockout approach and pharmacologic modulation to study the implication of the JNK pathway in regulating fibroblast motility, capa…