Skin, the biggest organ in mammals, protects the body from environmental hazards and prevents dehydration. Embryonic skin morphogenesis and homeostasis of adult skin require an accurately controlled gene expression in a spatiotemporally specific manner. Recently, the identification of microRNAs ...

June 28, 2023 - Scientists say they were able to stimulate hair growth in mice by utilizing an RNA particle, a development that could eventually lead to another treatment for baldness in humans

As one of the main appendages of skin, hair follicles play an important role in the process of skin regeneration. Hair follicle is a tiny organ formed by the interaction between epidermis and dermis, which has complex and fine structure and periodic ...

It is widely accepted that the periodic cycle of hair follicles is controlled by the biological clock, but the molecular regulatory mechanisms of the hair follicle cycle have not been thoroughly studied. The secondary hair follicle of the cashmere goat is characterized by seasonal periodic ...

Hair follicles are complex structures in the skin that play key roles in functions like hair growth and wound healing. However, our knowledge of how hair follicle stem cells (HFSCs) can divide and develop into different cell types, and their potential in hair regeneration is still limited.

During embryogenesis, multipotent progenitors within the single-layered surface epithelium differentiate to form the epidermis and its appendages. Here, we show that microRNAs (miRNAs) have an essential role in orchestrating these events. We cloned more than 100 miRNAs from skin and show that ...

June 6, 2023 - Researchers have successfully stimulated hair growth in mice using microRNA to genetically manipulate hair follicle stem cells, meaning that balding pate may one day be sporting a mane of luscious locks.

Hair follicles (HFs) enjoy a relative immune privilege (IP) that is characterized by downregulation of major histocompatibility complex (MHC) class I …

MicroRNA exerts an important regulatory role in almost all the biological process, including hair follicle development in Liaoning Cashmere goat. In order to improve the Cashmere performance of goat, the regulatory role of microRNA in hair follicle cycle has drawn hotspot attention.

Alopecia is a common problem that affects almost every age group and is considered to be an issue for cosmetic or psychiatric reasons. The loss of hair folli...

Hair follicles are an appendage of the vertebrate epithelium in the skin that arise from the embryonic ectoderm and regenerate cyclically during adulthood. Dermal papilla cells (DPCs) are the key dermal component of the hair follicle that directly regulate hair follicle development, growth ...

Genes & Immunity - Identification of differentially expressed miRNAs in alopecia areata that target immune-regulatory pathways

microRNAs have continued to attract enormous interest in the scientific community ever since their discovery. Their allure stems from their unique role in posttranscriptional gene expression control as well as their potential application as therapeutic ...

Hair growth disorders, particularly those that lead to hair loss (alopecia), are common and frequently cause significant mental anguish in affected in…

Alopecia areata (AA) is a type of immune-mediated alopecia. Recent studies have suggested microRNAs’ (miRNAs) implication in several cellular processes, including epidermal and hair follicle biology. Single nucleotide polymorphisms (SNPs) can modify gene expression levels, which may induce ...

Hair follicle stem cells (HFSCs) are among the most widely available resources and most frequently approved model systems used for studying adult stem cells. HFSCs are particularly useful because of their self-renewal and differentiation properties. Additionally, the cyclic growth of hair follicles ...

July 28, 2020 - As a general rule, people care too much about their hair and too little about their blood vessels. One can live without hair. It is interesting to see both (a) just how much work goes into the regeneration of lost hair, and (b) just how little is known of the fine details by which the...

June 28, 2024 - Hair follicles are tube-like structures within your skin that are responsible for growing your hair.

August 6, 2020 - Scientists at North Carolina State University have looked into microRNA (miRNA) for hair regrowth treatment. Their studies identified one miRNA that can pr | Drug Discovery And Development

July 28, 2020 - Researchers have identified a microRNA that plays an important role in regulating the pathway involved in follicle regeneration and could be a candidate for future hair regenerating drug development.