June 5, 2023 - This new miRNA plays an important role in regulating the pathway involved in follicle regeneration, and could be a candidate for future drug development.

MicroRNAs (miRNAs) are a major class of conserved non-coding RNAs that have a wide range of functions during development and disease. Biogenesis of canonical...

Further investigation of miRNA expression in the human HF, and the identification of novel miRNA target genes and pathways via the systematic integration of miRNA and mRNA expression data, may facilitate the delineation of tissue-specific regulatory interactions, and improve our understanding ...

Researchers have identified a microRNA that could promote hair regeneration.

August 28, 2024 - Researchers have identified a microRNA (miRNA) that could promote hair regeneration. This miRNA -- miR-218-5p -- plays an important role in regulating the pathway involved in follicle regeneration, and could be a candidate for future drug development.

By P49, control hair follicles ... as regularly spaced uniformly oriented structures (Figures 1U and 1U′). In contrast, hair follicles had degenerated in large stretches of Dicer mutant skin and were replaced by cyst structures or disorganized clumps of epithelial cells within the dermis (Figures 1V and 1V′). The epidermis remained expanded at this stage (Figures 1U–1V′). To begin to determine the basis for the defects in hair-follicle morphogenesis and maintenance observed in ...

During embryonic development, hair follicles (HFs) develop from an epidermal–mesenchymal cross talk between the ectoderm progenitor layer and the underlying dermis. Epidermal stem cell activation represents a crucial point both for HF morphogenesis and for hair regeneration. miR-24 is an ...

The periodic regrowth of rabbit fur is economically important. Here, we aimed to characterise the histological traits and microRNA (miRNA) expression profiles in the skin tissue of Wan Strain Angora rabbits at different weeks after plucking. Haematoxylin-eosin staining showed that hair follicles ...

The hair follicle is a dynamic mini-organ that has specialized cycles and architectures with diverse cell types to form hairs. Previous studies for several d...

The hair follicle is a cyclic biological system that progresses through stages of growth, regression, and quiescence, which involves dynamic changes in a program of gene regulation. Micro-RNAs (miRNAs) are critically important for the control of gene ...

Androgenetic alopecia (AGA) remains an unsolved problem for the well-being of humankind, although multiple important involvements in hair growth have been discovered. Up until now, there is no ideal therapy in clinical practice in terms of efficacy and ...

Alopecia is a common progressive disorder associated with abnormalities of the hair follicle cycle. Hair follicles undergo cyclic phases of hair growth (anag...

This article explores and summarizes recent progress in and the characterization of main players in the regulation and cyclic regeneration of hair follicles....

Hair follicle development is closely associated with wool curvature. Current studies reveal the crucial role of microRNAs (miRNAs) in hair follicle growth and development. However, few studies are known regarding their role in wool curvature. To reveal the potential roles of miRNAs in Hu sheep ...

https://doi.org/10.1007/s13577-021-00540-0 · Journal: Human Cell, 2021, № 4, p. 1040-1050

January 16, 2024 - In a piece reflecting on this month’s PLOS Genetics issue image, author Zhengquan Yu discusses the research behind Yuan et al. Author…

As one of the main appendages of skin, hair follicles play an important role in the process of skin regeneration. Hair follicle is a tiny organ formed by the interaction between epidermis and dermis, which has complex and fine structure and periodic ...

Abstract: Hair follicles in Dorper sheep are characterized by seasonal cyclic growth and development, consequently resulting in hair shedding during spring. The cyclic growth and development of hair follicles are regulated by several influencing factors such as photoperiods, hormones, age of ...

Hair follicles (HFs) enjoy a relative immune privilege (IP) that is characterized by downregulation of major histocompatibility complex (MHC) class I …

It is widely accepted that the periodic cycle of hair follicles is controlled by the biological clock, but the molecular regulatory mechanisms of the hair follicle cycle have not been thoroughly studied. The secondary hair follicle of the cashmere goat is characterized by seasonal periodic ...