Building on the cerebral distribution ... 1997), the amygdala has been established as a crucial region for oxytocin research, centering around its role in social cognition, face processing and threat detection (Adolphs, 2010, Davis and Whalen, 2001). While the effects of oxytocin ...

August 1, 2015 - Standard dopamine therapies for schizophrenia are not efficacious for negative symptoms of the disease, including asociality. This reduced social behavior may be due to glutamatergic dysfunction within the amygdala leading to increased fear and ...

The amygdala is a key region in current neurocircuitry models of reactive aggression as it is crucially involved in detecting social threat and provocation. An increased amygdala reactivity to angry faces has been reported in aggression-prone individuals and the neuropeptide oxytocin (OT) could ...

November 6, 2020 - Intranasal administration of the neuropeptide oxytocin (IN-OT) is increasingly considered as a potential treatment for targeting the core symptoms of autism spectrum disorder (ASD), but the effects of continual use on neural substrates are fairly unexplored and long-term effects are unknown.

March 7, 2022 - Effects on the amygdala may help to explain two of oxytocin’s broad effects, namely increased attention and orientation to social stimuli (Shamay-Tsoory and Abu-Akel, 2016) and reduced anxiety responses to social stimuli (Bethlehem et al., 2013, 2014). In light of its central role in social ...

March 16, 2020 - The ability to successfully regulate negative emotions such as fear and anxiety is vital for mental health. The neuropeptide oxytocin (OXT) acts as important modulator of emotion regulation, as reflected by reduced amygdala responses but increased amygdala–prefrontal cortex (PFC) functional ...

April 7, 2010 - Oxytocin (OT) is becoming increasingly established as a prosocial neuropeptide in humans with therapeutic potential in treatment of social, cognitive, and mood disorders. However, the potential of OT as a general facilitator of human learning and empathy is unclear.

August 2, 2015 - PDF | Standard dopamine therapies for schizophrenia are not efficacious for negative symptoms of the disease, including asociality. This reduced social... | Find, read and cite all the research you need on ResearchGate

Intravenous OT treatment did not produce these effects, despite comparable blood concentrations. ... Nose-to-brain delivery, or at least activity, may have occurred via olfactory and trigeminal nerve pathways. It is unclear if and how exogenous oxytocin (OT) reaches the brain to improve social behavior and cognition and what is the optimal dose for OT response. To better understand the delivery routes of intranasal OT administration to the brain and the dose-response, we compared amygdala ...

Oxytocin (OT) orchestrates social and emotional behaviors through modulation of neural circuits. In the central amygdala, the release of OT modulates inhibitory circuits and, thereby, suppresses fear responses and decreases anxiety levels. Using astrocyte-specific gain and loss of function ...

The ability to successfully regulate negative emotions such as fear and anxiety is vital for mental health. Intranasal administration of the neuropeptide oxytocin (OXT) has been shown to reduce amygdala activity but to increase amygdala–prefrontal ...

August 1, 2023 - I was inspired to discuss DOA by ... Lost Its Mind. Mr. Wheal is a brilliant thinker, weaving together seemingly disparate themes and proposing alluring concepts. However, D.O.A are not disparate; they are intimately intertwined. Wheal observes that every time we “listen to that amygdala alarm clock and find something ...that might make or break us—we get a strong squirt of dopamine.” Oxytocin, meanwhile, ...

November 30, 2019 - Accumulating evidence suggests that intranasal oxytocin (OXT; 24 IU) reduces amygdala responses to fear-related stimuli in men, while exerting inverse effects in women. However, OXT enhances activity of the brain reward system in both sexes. Importantly, a crucial and still open question is ...

Although OT had no effect on participants’ gazing behavior, it increased amygdala reactivity to scenes depicting social and non-social threat. In females, OT may, thus, enhance the detection of threatening stimuli in the environment, potentially by interacting with gonadal steroids, such as progesterone and estrogen. The neuropeptide oxytocin ...

Figure 5. Correlation differences ... and oxytocin (OXT) groups. Data from EE and SE trials are combined. In both cases the correlation difference between the OXT and PLC groups is significant (Fisher's Z-test p < 0.05). The current experiment demonstrated for the first time that OXT increases both empathic- and self-embarrassment ratings in male and female subjects and that its behavioral effects are associated with decreased responses in the right amygdala and in the ...

December 12, 2017 - Oxytocin signaling plays a critical role in a molecularly defined neuronal population of the Medial Amygdala to modulate the behavioral and physiological responses of male mice to females on a moment-to-moment basis.

July 31, 2018 - Accumulating evidence suggests that the neuropeptide oxytocin (OXT) can enhance empathy although it is unclear which specific behavioral and neural aspects are influenced, and whether the effects are modulated by culture, sex, and trait autism. Based on previous findings in Caucasian men, we hypothesized that a single intranasal dose of OXT would specifically enhance emotional empathy (EE) via modulatory effects on the amygdala ...

June 13, 2017 - Oxytocin in the amygdala suppresses freezing of mothers when exposed to a threat in the presence of their offspring, allowing for pup protection and transmission of information about danger from mothers to pups.