December 20, 2023 - LY-379,268 is a drug that is used in neuroscience research, which acts as a potent and selective agonist for the group II metabotropic glutamate receptors (mGluR2/3). It is derived from the older mGluR group II agonist eglumegad, and led on to the development of the more potent compound LY-404,039, ...

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The neuroprotective effects of a selective Group II metabotropic glutamate receptor (mGluR) agonist, LY379268, have been evaluated against global and focal cerebral ischaemia. Loss of CA1 hippocampal neurones following 5 min bilateral occlusion of the carotid artery (BCAO) in the gerbil was ...

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June 17, 2022 - The main purpose of this study is to evaluate the safety and tolerability of the study drug known as LY3540378 in healthy participants following single and mult...

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