November 5, 2024 - For rat studies, MSM following an acute oral intake of 500mg/kg bodyweight (estimated human dose of 80mg/kg) resulted in a brain concentration of 58.7+/-11.8μg/mL wet weight with a 0.921 tissue:serum ratio; this suggests MSM easily passes the blood brain barrier.[4] The human case study with an unspecified oral intake of MSM initially reported a concentration of 2.36mM with lower levels on day 2 (1.95mM), day 5 (1.11mM), and day 10 (0.75mM) following supplement cessation,[21] and a subsequent small trial of seven persons ingesting 1-3g MSM noted a variable concentration range of 0.42-3.40mM and appeared to evenly accumulate in grey and white brain matter[20] (the response to this article[23] is a clarification on the supplement brand used).

In contrast to our findings, recent ... decreased following MSM treatment [20]. Several studies have demonstrated decreased measures of inflammation and oxidative stress following MSM supplementation in models of exhaustive exercise, although pre-exercise measures do not appear ...

June 30, 2023 - In animal models, therapeutic effects ... models was improved in the MSM treatment groups [16,17]. Human clinical studies of MSM in patients with OA have also been conducted [18,19,20,21]. Administration of MSM relieved joint pain and ...

Methylsulfonylmethane (MSM) is ... tissue. Although animal studies suggest potential benefits in reducing inflammatory joint disease, clinical data in humans are lacking, necessitating further research on its efficacy and safety....

Although in a comprehensive review ... determined that MSM’s anti-inflammatory properties inhibited the breakdown of cartilage, decreased pain, and fortified joints....

November 5, 2024 - A 16-week study in humans compared ... found no difference in weight, blood pressure, and various blood markers, including white blood cell count, hemoglobin, platelets, glucose, creatine, bilirubin, and liver enzymes.[10] Other ...

July 21, 2017 - In one study, MSM significantly decreased malondialdehyde (MDA), myeloperoxidase (MPO), and IL-1β, while increasing glutathione (GSH) and catalase (CAT) production [20]. Another study showed that MSM pre-treatment significantly attenuated damaging ...

Preclinical and early clinical investigations suggest that MSM modulates proinflammatory cytokine release, supports cellular antioxidant defences, and may influence cell signalling pathways involved in tissue repair and immunity. Studies in animal models of acute renal failure and pulmonary ...

May 1, 2023 - Improvements in measures of metabolic health have been observed in mouse models of obesity and diabetes following MSM treatment. However, the effects of MSM on obesity‐related diseases in humans have not been investigated.

The purpose of this investigation will be to determine whether MSM supplementation improves markers of lung, cardiovascular and metabolic health, and markers of inflammation in overweight and obese adults.The expected outcome is that MSM will improve metabolic health, inflammatory and oxidative status, decreasing risk factors for cardiovascular and metabolic diseases. This study has been approved for human subject participation by the Washington State University Institutional Review Board

Results: Compared to placebo, MSM produced significant decreases in WOMAC pain and physical function impairment (P<0.05). No notable changes were found in WOMAC stiffness and aggregated total symptoms scores.

October 20, 2025 - MSM possesses antioxidant and ... pain during normal walking (2). Short-term studies have shown that MSM supplementation of 3 grams per dose significantly increases blood levels within 90 minutes (4)....

February 23, 2026 - Mechanism: Rapid passive absorption in the upper small intestine; water-soluble powder/solution promotes fast uptake. Tmax: Commonly ~1–2 hours in single-dose human studies; reported range 1–4 hours.

March 1, 2006 - MSM safety and toxicity clinical ... toxicity studies using single dose of 2g/kg and daily doses of 1.5g/kg MSM for 90 days showed no adverse events, organ pathology or mortality19.

MSM, rich in sulfur, is found in the human body. Clinical studies show that MSM reduces joint pain and swelling in osteoarthritis patients, while improving physical function and mobility.

May 1, 2025 - Muscle soreness can happen after ... muscles and surrounding connective tissues. Some studies suggest that taking MSM supplements may help reduce muscle soreness after exercise:...

June 5, 2026 - A recent study published in the journal Nutrients found that supplementation with a branded Methylsulfonylmethane (MSM), called OptiMSM for Balchem Human Nutrition & Health (Montvale, NJ), improved the quality of life in subjects with mild knee pain.

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May 24, 2023 - A study on 24 exercise-trained males found that those who took 3 g of MSM daily for 14 days had less pain and discomfort after exercise than those taking a placebo. It is important to note that none of the studies looked at a large group of ...

In human studies, MSM supplementation at 1.5 to 3 grams per day for periods up to 16 weeks has been shown to be safe and effective for improving markers of inflammation, exercise recovery, and cholesterol profiles Kalman2012Bloomer2019Miller2021.