Recently, molecular hydrogen has been investigated in preclinical and clinical studies on various diseases associated with oxidative and inflammatory stress such as radiation-induced heart disease, ischemia-reperfusion injury, myocardial and brain infarction, storage of the heart, heart ...

April 12, 2024 - Molecular hydrogen (H2) is an effective anti-inflammatory agent and has potential to ameliorate glycolipid metabolism disorders, which is believed to exert beneficial effects on the prevention and treatment of CHD.

After one month of hydrogen therapy, the cardiac function was ameliorated in the treated group compared to the control. Further analysis showed that the molecular hydrogen significantly attenuated the apoptosis and oxidative damage in cardiomyocytes. This suggests hydrogen gas as an effective ...

June 1, 2018 - Hydrogen (H2) is colorless, odorless, and the lightest of gas molecules. Studies in the past ten years have indicated that H2 is extremely important in regulating the homeostasis of the cardiovascular system and metabolic activity.

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January 22, 2024 - 7. Molecular Hydrogen Therapy for Cardiovascular Diseases · Damage to cardiomyocytes, vasculature—including endothelium and smooth muscle cells—are all CVD risk factors that result in cardiovascular dysfunction [35]. Increases in fibrosis ...

June 3, 2023 - Excessive oxidative stress and ... a small colorless and odorless molecule, is considered harmless in daily life when its concentration is below 4% at room temperature....

June 7, 2026 - Conclusion: As a safe antioxidant, molecular hydrogen mitigates the progression of CHF via inhibiting apoptosis modulated by p53. Therefore, from the translational point of view and speculation, H2 is equipped with potential therapeutic application ...

Compared with ischemic postconditioning, hydrogen had a better protective effect on I/R injury; this was associated with the attenuation of endoplasmic reticulum stress and the downregulation of excessive autophagy [39]. Treatment with HRS was also found to attenuate the myocardial injury and apoptosis in heart tissue induced by a cardiopulmonary bypass (CPB). The available evidence indicated that the protective effects of HRS involved opposite effects on two distinct signaling pathways, i.e., attenuation of the PI3K/Akt pathway [40] and upregulation of JAK2/STAT3 signaling [41]. The nonpolar nature and low molecular weight (2 Da) of molecular hydrogen allow it to easily penetrate biological membranes.

November 27, 2025 - Furthermore, it is important to note that numerous studies (over 2000 publications) have demonstrated the non-toxicity of molecular hydrogen across a wide range of concentrations. However, to establish safety within a specific disease model, it is necessary to analyze biochemical and histological markers of toxicity. In conclusion, this study demonstrates the trophic role of H2 during the early stages of chronic heart failure development.

The available literature indicates that H2 may be effective in mitigating different HF pathologies via regulating cardiac oxidative stress and inflammation, cardiomyocyte death, and mitochondrial function/cell metabolism, as well as cardiac remodeling, including hypertrophy and fibrosis. As this area of research is still in its infancy, the feasibility and efficiency of H2 treatment in different HF types need further investigation. Keywords: cardiac remodeling, cell death, heart failure, inflammation, molecular hydrogen, oxidative stress

November 28, 2025 - This is especially relevant in HF with preserved ejection fraction (HFpEF), which is strongly linked to obesity, insulin resistance, skeletal muscle metabolic inflexibility, and mitochondrial impairment. Current treatments neither restore mitochondrial energetics nor correct metabolic remodeling, leaving a critical driver of disease progression untreated [6]. Molecular hydrogen (H2) is considered a therapeutic gas for the treatment of various diseases.

August 16, 2021 - Admittedly, because of its good ... Schematic diagram of this study: Molecular hydrogen improves cardiac remodelling and fibrosis after myocardial infarction....

May 3, 2025 - Clinical studies have shown that hydrogen therapy can improve several metabolic parameters relevant to heart health. Hydrogen treatment has been shown to decrease serum total cholesterol, low-density lipoprotein cholesterol (LDL-C), and ...

February 2, 2023 - Molecular hydrogen has an anti-inflammatory and cardioprotective effect, which is associated with its antioxidant properties. Erythrocytes are subjected to oxidative stress in pathologies of the cardiovascular system, which is the cause of a ...