One interesting example of a compound with this profile is the phytocannabinoid Δ9-THCV, which is presently under investigation in preclinical models of PD [25]. Thus, there could well be clinical advantages to administering Δ9-THCV together with CBD as this might induce symptomatic relief (due to the blockade of CB1 by Δ9-THCV) and neuroprotection (due to the anti-oxidant and anti-inflammatory properties of both CBD and Δ9-THCV).

November 5, 2024 - High CBD Ratios (e.g., 20:1, 10:1) ... “high.” A 20:1 or 10:1 ratio typically contains negligible THC, making these products suitable for daytime use, social situations, or activities where mental clarity is needed....

May 19, 2025 - Discover THC to CBD ratio benefits, how to choose the right ratio, and boost your wellness with science-backed tips and guides.

Given the limitations of current pharmacological options for preventing or mitigating age-related cognitive decline, there is growing interest in alternative compounds with neuroprotective potential. Cannabidiol (CBD), a non-intoxicating component of cannabis, has recently emerged as a promising candidate. Unlike delta-9-tetrahydrocannabinol (THC), CBD does not produce intoxicating effects and has been shown to have anti-inflammatory, anxiolytic, and antioxidant properties (6–8).

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June 24, 2025 - Considering that CBD also has neuroprotective properties, combining it with Lion’s Mane is an excellent strategy for helping with cognitive decline in older adults.

July 15, 2024 - Patients with neuropathy may benefit from the anti-inflammatory, analgesic, and neuroprotective properties offered by this balanced ratio, potentially finding relief from symptoms like pain, numbness, tingling, and weakness.

In this review we will provide animal and human research data on the current clinical neurological uses for CBD individually and in combination with Δ9-THC. We will emphasize the neuroprotective, antiinflammatory, and immunomodulatory benefits of phytocannabinoids and their applications in various clinical syndromes.

September 9, 2021 - The combination of 1 µM THC with 0.05 µM CBD, which reproduces the cannabinoid concentrations of Bedrocan 1.8 µg/mL, produced a significant neurotoxic effect, but when the relative concentrations of CBD increased (0.1–10 µM), the neurotoxic ...

July 7, 1998 - Antioxidants such as α-tocopherol (5, 6) are effective neuroprotectants because of their ability to reduce the toxic reactive oxygen species (ROS) formed during ischemic metabolism. Cannabinoids like (−)Δ9-tetrahydrocannabinol (THC) and its psychoactive analogues also have been reported to be neuroprotective against glutamate toxicity in vitro (7).

July 11, 2025 - While choosing the ideal ratio may take some trial and error, here are some common CBD to THC ratios to help you start finding your perfect match.

The restored abundance and diversity of gut metabolome were considered contributing to the restored levels of short chain fatty acids, such as isovaleric, valeric and butyric acids, which may result in the reduced production of proinflammatory cytokines and attenuated EAE symptoms [75]. Collectively, the results from these studies suggested that combined THC and CBD treatment may provide a potential superior therapeutic approach to using CBD or THC alone for the treatment of MS individuals in the future by downregulating miRNAs and altering the gut microbiome. Beta-caryophyllene (BCP) is a bioactive compound found in Cannabis with potent and diverse pharmacological properties, including antimicrobial, cardioprotective, antioxidant, neuroprotective and anti-neuroinflammatory effects [76]. A recent study by Yoqubaitis et al.

Conclusions:In this review we will provide animal and human research data on the current clinical neurological uses for CBD individually and in combination with Δ9-THC. We will emphasize the neuroprotective, antiinflammatory, and immunomodulatory benefits of phytocannabinoids and their ...

These results indicate that cannabidiol exerts a neuroprotective effects against β-amyloid peptide toxicity suggesting the a possible involvement of cannabidiol in the signalling pathway for this neuroprotection. This hypothesis was supported by a further study where CBD inhibited both nitrite production and nitric oxide synthase (iNOS) protein expression induced by beta-A [31]. These results of in vitro studies were confirmed in vivo with a mouse model of AD-related neuroinflammation.

February 1, 2016 - Although the first effect depended on CB1 and CB2 receptor, the latter was not affected by pre-treatment with cannabinoid antagonists [56]. Besides CBD alone, its 1:1 combination with Δ(9)-tetrahydrocannabinol (THC) in the phytocannabinoid-based medicine Sativex®) also produced neuroprotective effects through a CB1- and CB2-mediated mechanism in a model of Huntington’s disease [57]. CBD might also facilitate the survival of newborn hippocampal neurons via facilitation of anandamide neurotransmission through CB1 receptors [52], [58].

The neuroprotection ratio of CBD against H2O2 ([H2O2]=10 μM) was 2.40 with 5 μM of CBD, increasing the cell viability to 57% from 24%. The CLSM analysis suggested that the cell-death mechanisms were different for CBD and H2O2, and CBD did ...

January 17, 2023 - In this article, we simplify and summarise the evidence for using a different CBD:THC Ratio for the treatment of a variety of indications

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January 15, 2024 - Moreover, THC has been found to inhibit acetylcholine esterase (AchE)-induced aggregation of amyloid-beta (Aβ), improve motor coordination deficits in R6/2 mice, mitigate striatal atrophy and huntingtin aggregate accumulation, and exacerbate malonate lesions in AD (Table 1) [99,100,101,102]. THC, THCA, and the metabolite cannabinol (CBN) have been described to possess analgesic, anti-inflammatory, and neuroprotective effects [103,104,105]. While there is still a need for further research on the anti-neuroinflammatory effects of CBG compared to CBD, several studies have discussed the neuroprotective properties of CBG against neuroinflammation (Table 1).