July 21, 2022 - Previous studies have confirmed ... herbal medicine to treat coughing caused by pulmonary inflammation, dyspnea due to asthma and cough, nausea caused by stomach disorders, restlessness, and thirst [28]. In this study, we ...

June 13, 2025 - The methodology involved the extraction ... a wealth of bioactive compounds, exhibiting notable antioxidant, anti-inflammatory, antidiabetic, and antitumor properties....

June 17, 2022 - Loquat (Eriobotrya japonica (Thunb.) Lindl.) is an evergreen tree native to China, which is introduced in many Mediterranean countries. As in many ancient medical systems, loquat leaves have been used in Moroccan traditional medicine to treat diabetes and its complications. This study aims to determine the nutritional and polyphenol composition and to evaluate the in vivo antidiabetic, and antihyperlipidemic properties and oral toxicity of a leaf aqueous extract (LLE) derived from loquat grown in Morocco.

Recent research evidence has shown that loquat leaf or seed extracts are useful in prevention and control of both type-1 and type-2 diabetes [27,28,29,30,31,32,33]. A 70% ethanol extract of Folium Eriobotryae (30 g/kg) showed significant hypoglycemic effect on alloxan-diabetic mice by lowering ...

CCl4-treated rats that were given ... profiles. Thus, we conclude that Eriobotrya leaf extract and its fractions have a hepatoprotective effect against CCl4-induced hepatotoxicity in rats....

November 15, 2022 - Other beneficial physiological effects such as antioxidant, hepatoprotective, bronchodilatory, antitussive, and expectorant effects and tracheal smooth muscle relaxation, protection against myocardial ischemia injury, and improved cognitive activities have also been reported. High doses of E. japonica leaf extracts have been used in laboratory animals, and no side effects or toxicity-symptoms have been observed.

September 6, 2024 - Lee CH, Wu SL, Chen JC, Li CC, Lo HY, Cheng WY, Lin JG, Chang YH, Hsiang CY, Ho TY. Eriobotrya japonica leaf and its triterpenes inhibited lipopolysaccharide-induced cytokines and inducible enzyme production via the nuclear factor-kappaB signaling pathway in lung epithelial cells.

August 1, 2025 - You MK, et al. (2016). Loquat (Eriobotrya japonica) leaf extract inhibits the growth of MDA-MB-231 tumors in nude mouse xenografts and invasion of MDA-MB-231 cell.

October 5, 2023 - Loquat (Eriobotrya japonica) leaves contain many bioactive components such as ursolic acid (UA) and amygdalin. We investigated the effects of loquat leaf powder and methanol extract in human neuroglioma H4 cells stably expressing the Swedish-type APP695 (APPNL-H4 cells) and C57BL/6 J mice.

Hepatoprotective Effect of Eriobotrya japonica Leaf Extract and Its Various Fractions against Carbon Tetra Chloride Induced Hepatotoxicity in Rats.

April 5, 2018 - Total sesquiterpene glycosides from Loquat (Eriobotrya japonica) leaf alleviate high-fat diet induced non-alcoholic fatty liver disease through cytochrome P450 2E1 inhibition

Leaves of Eriobotrya japonica (LEJ) Lindl (Rosaceae) have been used as traditional medicines for lung and stomach diseases and have been found to be effective in chronic bronchitis, inflammation, asthma, low back pain and tumor.1–3,4 Studies have demonstrated that LEJ has anti-inflammatory ...

We investigated whether EJEE can regulate melanin production because melanin plays an essential role against UV-induced ROS production, EJEE has demonstrated potent anti-oxidant and anti-inflammatory activities [38, 39]. Recent studies have shown that hyperpigmentation is caused by various inflammatory skin disorders, such as eczema, and dermatitis [8, 9, 40, 41]. In this study, melanin content was significantly inhibited by EJEE at concentrations of 0.05 and 0.1%. Recently, Tan et al. [42] reported that the methanolic extract of Eriobotrya japonica leaf exhibits a significant dose-dependent inhibition of melanogenesis in B16 melanoma cells.

September 2, 2025 - Modern extracts concentrate bioactive triterpene acids (notably ursolic and oleanolic acids), flavonoids, and procyanidins that show anti-inflammatory, antioxidant, and immunomodulatory actions in laboratory and early human studies.

Our findings provide valuable evidence that E. japonica leaves have potential applications as ingredients of function foods or cosmetics for health benefits and a number of triterpenoids may play an important role in these bioactivities. Keywords: Eriobotrya japonica, loquat leaves, triterpenoids, skin disorder, anti-melanogenesis, anti-acne, anti-allergy, anti-aging

The Rosaceae family includes the evergreen subtropical tree known as Eriobotrya japonica Lindl (loquat). To test the effect of several E. japonica leaf extracts on shielding the heart from carbon tetrachloride (CCl4) cytotoxic effects, we employed ...

November 15, 2025 - Research suggests leaf extracts down-regulate inflammatory mediators like IL-6 and TNF-α in lung epithelial cells. Fruit pulp, rich in sugars and organic acids, acts more on the gut microflora, promoting bifidobacteria growth.

December 17, 2013 - Loquat (Eriobotrya japonica) leaves have been used as traditional medicine for chemoprevention and treatment of chronic inflammatory diseases although the evidence supporting their functions is still poor. This study aims to clarify the anti-inflammatory effects and molecular mechanisms of loquat tea extract (LTE), in both cell and animal models.