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Sanxinherbs
sanxinherbs.com › knowledge › is-acorus-gramineus-toxic
Is Acorus gramineus toxic? - Sanxin
Toxicological Concerns: Studies have indicated that β-asarone may have toxicological implications, including potential carcinogenic effects. High levels of β-asarone in calamus products have led to cautionary measures to protect public health.
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ScienceDirect
sciencedirect.com › topics › pharmacology-toxicology-and-pharmaceutical-science › acorus-calamus
Acorus Calamus - an overview | ScienceDirect Topics
Commentary: β-asarone is toxic for human (carcinogenic) (Cartus et al., 2015). However it could be used as a starting material for the synthesis of safer antiparasitic agents? What is the mode of antiparasitic action of asarones? Acorus calamus L.
chemical compound
Asarone is chemical compound of the phenylpropanoid class found in certain plants such as Acorus and Asarum. There are two isomers, α (or trans) and β (or cis). As a volatile fragrance … Wikipedia
Factsheet
Identifiers
CAS Number 2883-98-9 (α) Y
5273-86-9 (β) Y
3D model (JSmol) (α): Interactive image
(β): Interactive image
Factsheet
Identifiers
CAS Number 2883-98-9 (α) Y
5273-86-9 (β) Y
3D model (JSmol) (α): Interactive image
(β): Interactive image
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Wikipedia
en.wikipedia.org › wiki › Asarone
Asarone - Wikipedia
November 19, 2025 - The Council of Europe Committee of Experts on Flavouring Substances concluded that β-asarone is clearly carcinogenic and has proposed limits for its concentration in flavorings such as bitters made from Acorus calamus (sweet flag).
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PubMed Central
pmc.ncbi.nlm.nih.gov › articles › PMC10692820
Insecticidal toxicity of essential oil of Nepalese Acorus calamus (Acorales:Acoraceae) against Sitophilus zeamais (Coleoptera:Curculionidae) - PMC
However, from the perspective of health benefits, Acorus calamus treated maize is still questionable for feed and food purpose. As β asarone has carcinogenic effects at certain level, it needs further residue tests of treated maize to know allowable maximum residue limit (MRL) before consumption as food or feed. Keywords: Sweet flag, Maize weevil, Oil extraction, Concentrations, Management
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ResearchGate
researchgate.net › publication › 257746829_Acute_and_sub-acute_oral_toxicity_profile_of_Acorus_calamus_Sweet_flag_in_rodents
Acute and sub-acute oral toxicity profile of Acorus calamus (Sweet flag) in rodents | Request PDF
February 1, 2012 - Mild but acceptable toxicity of rhizome extract of this plant was observed at high doses by · Muthuraman and Singh (2012). β-asarone, a compound from this plant is potentially toxic and carcinogenic (Taylor et al., 1967;Keller and Stahl, 1983), ...
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Knowledge Voyager
knowledgevoyager.com › home › calamus root: the sweet flag’s hidden beta-asarone with mild psychoactive effects
Calamus Root: The Sweet Flag’s Hidden Beta-Asarone with Mild Psychoactive Effects - Knowledge Voyager
May 23, 2024 - Research has shown that beta-asarone, when consumed in high doses or over an extended period, may have toxic effects on the liver and kidneys. It is recommended to use Calamus root in moderation and consult with a healthcare provider before ...
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ACS Publications
pubs.acs.org › doi › 10.1021 › acs.chemrestox.5b00223
Hepatic Metabolism of Carcinogenic β-Asarone | Chemical Research in Toxicology
Nitrogen fertilization and the essential oils profile of the rhizomes of different sweet flag populations (Acorus calamus L.). Industrial Crops and Products 2019, 142 , 111871. https://doi.org/10.1016/j.indcrop.2019.111871 · Thomas Uebel, Markus Wilken, Hung Vu Chi, Melanie Esselen. In vitro combinatory cytotoxicity of hepatocarcinogenic asarone isomers and flavonoids. Toxicology in Vitro 2019, 60 , 19-26.
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Reddit
reddit.com › r/psychonaut › if you haven't yet heard of acorus calamus (bitterroot, sweet flag) i'm here to try and fix that.
r/Psychonaut on Reddit: If you haven't yet heard of Acorus Calamus (Bitterroot, Sweet Flag) I'm here to try and fix that.
August 26, 2015 -

Recently I bought a pound of Calamus root along with a few other herbs and have stumbled upon a new obsession.

I want to spread the word here because I figure it would make a great plant ally for anyone who's exploring with psychedelics. It's not the sort of thing you can just take once on the spot and have it work, but if you work at it you can tame the Bitterroot and rely on it to take care of you. I have been chewing it in small amounts (for long periods of time) a few times throughout the day for the past 4 days and it effectively dissolved the minor social anxiety I've been aware of having for quite some time. It makes me psychically fearless, and so I think of it as my 'psychic ally'.

It is intensely grounding, calming, and realigning in a very unique way. I've used lemon balm, passion flower, valerian, blue lotus, kanna, wild dagga, and many other centering, calming, trance inducing, and focus driving herbs but Bitterroot stands out to me as especially warm and reliable. It feels like the energy of a good friend that wants the best for me, that sense of caring is what I think soothes me. The effect, I have to stress, is not overt by any means. This is one of many aspects of Bitterroot that requires work on your end... if you feel a calling from the plant I believe you can get a great deal out of it, but it will not simply be handed over. Another aspect is the taste.

It is not bad tasting per se but it is intensely bitter and intensely bizarre. It takes getting used to but if you keep at it you will come to like it, maybe even love it. You chew the fresh or dried root, other ROA are possible but not preferable in my opinion.

There is really too much I would like to say but I'm far too stoned for this shit right now. I hope some people's interest has been piqued enough to read the article I came here to post:

http://www.herbcraft.org/calamus.html

I'll be in the comments if anyone wants to talk about this stuff. Also, like I said, I'm sitting on a pound of the stuff so I'm willing to send a couple people an envelope stuffed with a couple tablespoons of it if you are interested... and in the US.

EDIT: One major interest I have with this plant is for use when tripping. I feel like just having some on me in case I need it might even be enough to keep me level headed if the going gets rough. I might microdose some mushrooms and chew Calmus tomorrow, if I do I'll be sure to report back.

Find elsewhere
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ScienceDirect
sciencedirect.com › science › article › abs › pii › S2221169112603542
Acute and sub-acute oral toxicity profile of Acorus calamus (Sweet flag) in rodents - ScienceDirect
September 6, 2012 - Mild but acceptable toxicity of rhizome extract of this plant was observed at high doses by Muthuraman and Singh (2012). β-asarone, a compound from this plant is potentially toxic and carcinogenic (Taylor et al., 1967; Keller and Stahl, 1983), ...
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Limonium
plantids.com › 81-acorus-calamus.html
Acorus calamus: Identification, Health Benefits, Uses, Invasive Concerns, and Pet Safety
While Acorus calamus has many benefits, it also comes with some risks: Toxicity : Ingesting large amounts of the plant can be toxic due to the presence of β-asarone, a compound found in some varieties of the plant.
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Practical Plants
practicalplants.org › wiki › acorus_calamus
Acorus calamus (Sweet Flag) - Practical Plants
The fresh root can be poisonous[1]. ... plant contains the compound asarone. This has tranquillising and antibiotic activity, but is also potentially toxic and carcinogenic[3][4]. It seems that these compounds are found in the triploid form of the species (found in Asia) whilst ...
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MDPI
mdpi.com › 2076-3417 › 12 › 21 › 11007
Ultrasound-Assisted Extraction of β-Asarone from Sweet Flag (Acorus calamus) Rhizome
October 30, 2022 - It was reported that prolonged exposure to A. calamus could cause toxification and excessive vomiting [14]. It was also reported that both α- and β- asarone are cytotoxic, genotoxic and hepatocarcinogenic [12,15,16]. Due to the reported toxicity ...
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PubMed
pubmed.ncbi.nlm.nih.gov › 20040135
Bioanalytical investigation of asarone in connection with Acorus calamus oil intoxications - PubMed
Preparations of the plant Acorus calamus (calamus or sweet flag) (A. calamus) are available via internet trade and marketed as being hallucinogenic. In 2003-2006, the Swedish Poisons Information Centre received inquiries about 30 clinical cases of intentional intoxication with A. calamus products. The present investigation aimed to identify alpha- and beta-asarone, considered active components of A.
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Wikipedia
en.wikipedia.org › wiki › Acorus_calamus
Acorus calamus - Wikipedia
2 days ago - The asarone from A. calamus, found ... carcinogenicity in mammals (including humans) means that it may be difficult to develop any practical medications or insecticides based on it....
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Inchem
inchem.org › documents › jecfa › jecmono › v16je04.htm
498. Asarone, beta- (WHO Food Additives Series 16)
(a) Pathology report by William S. Monlux (August 1978) entitled "Microscopic lesions occurring in one hundred and ninety-four rats fed beta-asarone in their diet for twenty-four months" (This report indicates that a level of 2500 ppm beta-asarone was fed in the study; this group received Jammu oil of calamus not beta-asarone.) (b) Memo from Robert T. Habermann to Jean Taylor (16 June 1971) entitled "Carcinogenicity of beta-asarone in rats in a two-year feeding study".
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Tea Tree Place
teatreeplace.com › calamus-essential-oil
Calamus Oil - Uses, Health Benefits, Nutrition Facts & Side Effects
This has not been proven however this essential oil seems to have procarcinogenic effect on ingested. This was pointed out in a study that a nutrient from calamus, called β – asarone may have carcinogenic effects, although quite weak.
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Wiley Online Library
analyticalsciencejournals.onlinelibrary.wiley.com › doi › 10.1002 › jat.4112
α‐Asarone, β‐asarone, and γ‐asarone: Current status of toxicological evaluation - Uebel - 2021 - Journal of Applied Toxicology - Wiley Online Library
November 25, 2020 - Hepatopathological findings were observed for β-asarone (≥400 ppm), but no neoplastic potential was described at any dose. Clear carcinogenic potential of β-asarone and calamus-containing oils is questionable based on the week reported data ...
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Eatweeds
eatweeds.co.uk › sweet-flag-acorus-calamus
Sweet Flag – Robin Harford from Eatweeds
However, it is important to exercise caution due to the plant’s potential toxicity. The essential oil in the root contains asarone, a compound with potential carcinogenic properties.
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ScienceDirect
sciencedirect.com › topics › agricultural-and-biological-sciences › calamus
Calamus - an overview | ScienceDirect Topics
Acorus is considered unsafe for ... in rats treated with β-asarone (Wiseman et al., 1987). FDA studies have shown that only calamus native to India contains the carcinogenic β-asarone....
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WebMD
webmd.com › drugs & supplements › calamus
Calamus: Overview, Uses, Side Effects, Precautions, Interactions, Dosing and Reviews
When taken by mouth: Calamus is likely unsafe. The US FDA prohibits using calamus in food products because some species contain a cancer-causing chemical called beta-asarone. The amount of beta-asarone in calamus species can vary widely. In addition to cancer, side effects might include nausea ...