Initially thought to be virtually free of negative effects, benzodiazepines are now known to carry risks of dependence, withdrawal, and negative side effects. Among the most controversial of these side effects are cognitive effects. Long-term treatment with benzodiazepines has been described ...

Furthermore, the degree of recovery that may take place after withdrawal or the level of residual impairment, if any, that is maintained in long-term benzodiazepine users is also unclear. The current paper employed meta-analytic techniques to address two questions: (1) Does the cognitive function ...

December 13, 2017 - Other findings, such as the negative effect on processing speed performance (−0.76) were comparable across the meta-analyses (−0.72) (Barker et al., 2004a). For users who had withdrawn from long-term benzodiazepine use, they were still significantly impaired in all areas of cognitive function ...

July 14, 2023 - They can also result in delayed response time and an altered perception of self, environment, and relationships in addition to causing deficits in expressive language, working memory, visuoconstruction, and divided attention.2,6 · In a meta-analysis that included 13 studies in which the average ...

August 24, 2024 - The effects of long-term benzodiazepine use include drug dependence as well as the possibility of adverse effects on cognitive function, physical health, and mental health. Long-term use is sometimes described as use not shorter than three months. Benzodiazepines are generally effective when ...

Our findings were consistent with three previous case-control studies that reported no significant association between BZD use and cognitive function impairment. 28–31 Among the existing studies, a variety of different tools were used to measure cognitive status, and most studies had a sample ...

It has been known for many years that all benzodiazepines, like other sedative-hypnotic drugs, can interfere with memory functions (1). Clinical experience (2) as well as a retrospective meta-analysis (3) suggest that any related memory impairment is primarily recent recall and is often mild ...

It's been known for decades that long-term use of the psychoactive drugs benzodiazepines can lead to addiction and cognitive impairment, especially in older people. In a recent study, researchers pinpointed the cellular mechanism to explain this effect.

This study aimed to evaluate the effect of short-term use of benzodiazepines (BZDs) on cognitive function of major depressive disorder (MDD) patients …

In a study with participants with an average education level of <9 years, Helmes and Ostbye found that auditory memory functioning in BZD users was significantly impaired compared with that of non-users (47). These inconsistencies may be related to the high educational level of the participants ...

March 6, 2022 - Mouse study reveals synaptic loss associated with a daily sleep-inducing dose of diazepam for several weeks leads to cognitive impairments. However, the effect was reversible after discontinuing benzodiazepine use.

August 30, 2022 - Abstract. Background: Benzodiazepines are widely used in the treatment of anxiety disorders and sleep disturbances, but negative cognitive side effects have been reported after long-term use. Studies on the cognitive effects of long-term benzodiazepine use to date have typically included small ...

Owing to the low therapeutic index of barbiturates, benzodiazepines (BZDs) became popular in this country and worldwide many decades ago for a wide range of conditions. Because of an increased understanding of pharmacology and physiology, the mechanisms ...

November 15, 2023 - The drug may be a risk factor for dementia-related illnesses.

May 17, 2024 - Benzodiazepines are medications that slow down activity in your brain and nervous system. These medications are controlled substances, but still see widespread use.

February 1, 2005 - Download Citation | The effect of benzodiazepines on cognition | Initially thought to be virtually free of negative effects, benzodiazepines are now known to carry risks of dependence, withdrawal, and negative... | Find, read and cite all the research you need on ResearchGate

Acute benzodiazepine withdrawal has been described, but literature regarding the benzodiazepine-induced neurological injury that may result in enduring symptoms and life consequences is scant.We conducted an internet survey of current and former benzodiazepine ...

Several observational studies have found a link between the long-term use of benzodiazepines and dementia, which remains controversial. Our study was designed to assess (i) whether the long-term use of benzodiazepines, at two different doses, has an irreversible effect on cognition, (ii) and ...

ObjectiveBenzodiazepines (BZD) are one of the most frequently prescribed drugs worldwide. However, the cognitive effects of benzodiazepines in the elderly ar...