YE6144, YE 6144, IRF5 inhibitor. YE6144 (YE 6144) is a specific small molecule inhibitor of transcription factor IFN regulatory factor 5 (IRF5), selectively suppresses IRF5 activity through inhibition of IRF5 phosphorylation.
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Download scientific diagram | Suppression of IRF5 and type I IFN by a prototypical IRF5 inhibitor YE6144 a Chemical structure of YE6144. b IRF5 NT in monocytes (Mo; left) or pDCs (right) sorted from human HC PBMCs that were pretreated with the vehicle (DMSO) or 1 μM YE6144 for 30 min and then ...
IRF5 is a potential target for therapy in systemic lupus erythematosus (SLE). Here the authors show using mouse SLE-like models that genetic or chemical inhibition of IRF5 after SLE onset could be more effective than, or an add on for, currently utilised type I interferon inhibition.
YE6144 is a specific small molecule inhibitor of transcription factor IFN regulatory factor 5 (IRF5), selectively suppresses IRF5 activity through inhibition of IRF5 phosphorylation.
YE6144 is a prototypical interferon regulatory factor 5 (IRF5) inhibitor. YE6144 selectively suppresses IRF5 activity through inhibition of IRF5 phosphorylation. - Mechanism of Action & Protocol.
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A reporter system that distinguishes the transcriptional activities of IRF5 and NF-κB was established and used for HTS. A library containing ~100,000 compounds was subjected to the screening via the reporter system to identify the compounds that selectively inhibit IRF5 transcriptional activity, ...
Novel selective IRF5 inhibitor, inhibiting the phosphorylation of IRF5 in both human PBMCs and mouse splenocytes
YE6144 is a typical inhibitor of interferon regulatory factor 5 (IRF5), which inhibits IRF5 phosphorylation and thus selectively inhibits IRF5 activity.