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The most straight forward way is probably the same as for nodejs apps (using pkg). So you'd sidecar a packaged python app created with pyinstaller or something.
Or, if you're absolutely crazy and proficient in rust there's also this one: https://github.com/RustPython/RustPython. But i don't know how easy it would be to use it for a whole py project with dependencies (if it's even possible).